Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma
Josephine G. M. Strijker,
Guillem Pascual-Pasto,
Yannine J. Kalmeijer
et al.
Abstract:While chimeric antigen receptor (CAR) T-cell therapies are showing highly promising first results in neuroblastoma, immunosuppressive tumor microenvironments (TME) limit T cell persistence and durable clinical efficacy. To improve CAR T-cell efficacy further, we applied a multi-omics approach including single-cell RNA sequencing and proteomics, which identified 13 targetable immunosuppressive factors in neuroblastoma. Of these, macrophage migration inhibitory factor (MIF) and midkine (MDK) were validated acros… Show more
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