Blockade of the dorsal hippocampal dopamine D1 receptors inhibits the scopolamine-induced state-dependent learning in rats

Piri, Morteza; Rostampour, Masoumeh; Nasehi, Mohammad; Zarrindast, Mohammad Reza

doi:10.1016/j.neuroscience.2013.08.003

Cited by 21 publications

(12 citation statements)

References 46 publications

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“…The results of the current study showed that the pre-training Intra-CA1 injection of SCO could impair the memory retrieval of mice when tested 24 hours later in step-down passive avoidance task. The current study findings were in agreement with those of similar observations by Piri et al (2013) . They showed that pre-training Intra-CA1 administration of SCO could induce memory impairment in one-trial step-down inhibitory avoidance task in rats.…”

Section: Discussionsupporting

confidence: 94%

“…Scopolamine (SCO) is a cholinergic antagonist that blocks most types of muscarinic receptors and induces amnesia via dysregulation of cholinergic system activity ( Piri, Rostampour, Nasehi, & Zarrindast, 2013 ). Scopolamine is also used by scientists to induce memory failure in a variety of learning and memory models, especially in step-down passive avoidance memory in human and mice ( Duka, Edelmann, Schutt, Dorow, & Fichte, 1992 ; Lo et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

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Research Paper: Cross State-dependent Learning Interaction Between Scopolamine and Morphine in Mice: The Role of Dorsal Hippocampus

Maleki

Hassanpour-Ezatti

Navaeian

2017

BCN

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Introduction:The current study aimed at investigating the existence of the cross state-dependent learning between morphine and scopolamine (SCO) in mice by passive avoidance method, pointing to the role of CA1 area.Methods:The effects of pre-training SCO (0.75, 1.5, and 3 μg, Intra-CA1), or morphine (1, 3, and 6 mg/kg, intraperitoneal (i.p.) was evaluated on the retrieval of passive avoidance learning using step-down task in mice (n=10). Then, the effect of pretest administration of morphine (1.5, 3, and 6 mg/kg, i.p.) was examined on passive avoidance retrieval impairment induced by pre-training SCO (3 μg/mice, Intra-CA1). Next, the effect of pretest Intra-CA1 injection of scopolamine (0.75, 1.5, and 3 μg/mice) was evaluated on morphine (6 mg/kg, i.p.) pre-training deficits in this task in mice.Results:The pre-training Intra-CA1 injection of scopolamine (1.5 and 3 μg/mouse), or morphine (3 and 6 mg/kg, i.p.) impaired the avoidance memory retrieval when it was tested 24 hours later. Pretest injection of both drugs improved its pre-training impairing effects on mice memory. Moreover, the amnesia induced by the pre-training injections of scopolamine (3 μg/mice) was restored significantly (P<0.01) by pretest injections of morphine (3 and 6 mg/kg, i.p.). Similarly, pretest injection of scopolamine (3 μg/mice) restored amnesia induced by the pre-training injections of morphine (6 mg/kg, i.p.), significantly (P<0.01).Conclusion:The current study findings indicated a cross state-dependent learning between SCO and morphine at CA1 level. Therefore, it seems that muscarinic and opioid receptors may act reciprocally on modulation of passive avoidance memory retrieval, at the level of dorsal hippocampus, in mice.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Research Paper: Cross State-dependent Learning Interaction Between Scopolamine and Morphine in Mice: The Role of Dorsal Hippocampus

Maleki

Hassanpour-Ezatti

Navaeian

2017

BCN

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“…1a,b), consistent with the preferential role of the hippocampus in contextual fear versus cue-dependent learning 13,14 . Muscarinic cholinergic receptors have also been implicated in state-dependent learning 6 , but antagonism of these receptors by scopolamine impaired memory without generating state-dependent effects (Supplementary Fig. 2).…”

Section: Resultsmentioning

confidence: 99%

“…In contrast with these generally beneficial effects, it has also been implicated in the nonintegrated encoding of stress-related memories and emotions, placing individuals at risk for a wide variety of psychiatric disorders 3,4 . State dependency of learning and memory under various psychoactive drugs has been shown in rodent models of reinforcement learning 5 and passive avoidance 6 ; however, the molecular and circuit mechanisms of state-dependent learning in general, and fear-related state-dependent learning in particular, remain unknown.…”

mentioning

confidence: 99%

GABAergic mechanisms regulated by miR-33 encode state-dependent fear

et al. 2015

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Fear-inducing memories can be state dependent, meaning that they can best be retrieved if the brain states at encoding and retrieval are similar. Restricted access to such memories can present a risk for psychiatric disorders and hamper their treatment. To better understand the mechanisms underlying state-dependent fear, we used a mouse model of contextual fear conditioning. We found that heightened activity of hippocampal extrasynaptic GABAA receptors, believed to impair fear and memory, actually enabled their state-dependent encoding and retrieval. This effect required protein kinase C-βII and was influenced by miR-33, a microRNA that regulates several GABA-related proteins. In the extended hippocampal circuit, extrasynaptic GABAA receptors promoted subcortical, but impaired cortical, activation during memory encoding of context fear. Moreover, suppression of retrosplenial cortical activity, which normally impairs retrieval, had an enhancing effect on the retrieval of state-dependent fear. These mechanisms can serve as treatment targets for managing access to state-dependent memories of stressful experiences.

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“…Amnesic effects of scopolamine have been verified by a variety of learning paradigms such as T-maze alternation task and object recognition test, respectively [8]. This model is frequently employed as a quick way for testing new drugs as cognition enhancers [9]. In healthy adults, scopolamine has been used to create impairment in memory and information processing speed and efficiency that resembles impairments in patients with AD [10].…”

Section: Introductionmentioning

confidence: 99%

Anthriscus nemorosa essential oil inhalation prevents memory impairment, anxiety and depression in scopolamine-treated rats

Bağcı

Aydin

Ungureanu

et al. 2016

Biomedicine & Pharmacotherapy

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Anthriscus nemorosa (Bieb.) Sprengel is used for medicinal purposes in traditional medicine around the world, including Turkey. Ethnobotanical studies suggest that Anthriscus essential oil could improve memory in Alzheimer's disease. The current study was hypothesized to investigate the beneficial effects of inhaled Anthriscus nemorosa essential oil on memory, anxiety and depression in scopolamine-treated rats. Anthriscus nemorosa essential oil was administered by inhalation in the doses of 1% and 3% for 21 continuous days and scopolamine (0.7mg/kg) was injected intraperitoneally 30min before the behavioral testing. Y-maze and radial arm-maze tests were used for assessing memory processes. Also, the anxiety and depressive responses were studied by elevated plus-maze and forced swimming tests. As expected, the scopolamine alone-treated rats exhibited the following: decrease the percentage of the spontaneous alternation in Y-maze test, increase the number of working and reference memory errors in radial arm-maze test, decrease of the exploratory activity, the percentage of the time spent and the number of entries in the open arm within elevated plus-maze test and decrease of swimming time and increase of immobility time within forced swimming test. However, dual scopolamine and Anthriscus nemorosa essential oil-treated rats showed significant improvement of memory formation and exhibited anxiolytic- and antidepressant-like effects in scopolamine-treated rats. These results suggest that Anthriscus nemorosa essential oil inhalation can prevent scopolamine-induced memory impairment, anxiety and depression.

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Blockade of the dorsal hippocampal dopamine D1 receptors inhibits the scopolamine-induced state-dependent learning in rats

Cited by 21 publications

References 46 publications

Research Paper: Cross State-dependent Learning Interaction Between Scopolamine and Morphine in Mice: The Role of Dorsal Hippocampus

Research Paper: Cross State-dependent Learning Interaction Between Scopolamine and Morphine in Mice: The Role of Dorsal Hippocampus

GABAergic mechanisms regulated by miR-33 encode state-dependent fear

Anthriscus nemorosa essential oil inhalation prevents memory impairment, anxiety and depression in scopolamine-treated rats

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