Blockade of Stearoyl-CoA-desaturase 1 activity reverts resistance to cisplatin in lung cancer stem cells

Pisanu, Maria Elena; Noto, Alessia; Vitis, Claudia De; Morrone, Stefania; Scognamiglio, Giosuè; Botti, Gerardo; Venuta, Federico; Diso, Daniele; Jakopin, Žiga; Padula, Fabrizio; Rícci, Alberto; Mariotta, Salvatore; Giovagnoli, Maria Rosaria; Giarnieri, Enrico; Amelio, Ivano; Agostini, Massimiliano; Melino, Gerry; Ciliberto, Gennaro; Mancini, Rita

doi:10.1016/j.canlet.2017.07.027

Cited by 101 publications

(94 citation statements)

References 54 publications

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“…Many studies reported that pharmacologic or genetic interference with SCD remarkably accelerated the process of cellular apoptosis in different types of cancer. Moreover, SCD inhibition could also significantly increase the sensitivity of cells to chemotherapy‐induced apoptosis . To determine whether a similar result could also be observed in bladder cancer cells after treatment with A939572 and pirarubicin alone or in combination, we performed an apoptosis assay in both the UMUC3 and RT4 cell lines.…”

Section: Resultsmentioning

confidence: 92%

“…H, after either 24-h treatment of A939572 or siRNAs, Cyclins D1, Rb, PCNA, Cdk4 and Cdk6 were down-regulated, while cyclin E1 was up-regulated significantly increase the sensitivity of cells to chemotherapy-induced apoptosis. 12 To determine whether a similar result could also be observed in bladder cancer cells after treatment with A939572 and pirarubicin alone or in combination, we performed an apoptosis assay in both the UMUC3 and RT4 cell lines. The results suggested that compared with treatment with DMSO, treatment with pirarubicin alone at a concentration of 100 ng/mL significantly increased cell apoptosis.…”

Section: The Combination Of An Scd Inhibitor and Pirarubicin Does Nmentioning

confidence: 94%

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Inhibition of stearoyl CoA desaturase‐1 activity suppresses tumour progression and improves prognosis in human bladder cancer

Piao

Cui

Zhan

et al. 2018

J Cellular Molecular Medi

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Urinary bladder neoplasm is one of the most common cancers worldwide. Cancer stem cells (CSCs) have been proven to be an important cause of cancer progression and poor prognosis. In the present study, we established bladder CSCs and identified the crucial differentially expressed genes (DEGs) between these cells and parental bladder cancer cells. Analyses of bioinformatics data and clinical samples from local hospitals showed that stearoyl CoA desaturase‐1 (SCD) was the key factor among the DEGs. A significant correlation between SCD gene expression and poor prognosis among patients with bladder cancer was observed in our data. Loss‐of‐function experiments further revealed that the SCD inhibitor A939572 and SCD gene interference reduced cell proliferation and invasion. The above data suggest that SCD may serve as a novel marker for the prediction of tumour progression and poor prognosis in patients with bladder cancer.

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Section: Resultsmentioning

confidence: 92%

Section: The Combination Of An Scd Inhibitor and Pirarubicin Does Nmentioning

confidence: 94%

Inhibition of stearoyl CoA desaturase‐1 activity suppresses tumour progression and improves prognosis in human bladder cancer

Piao

Cui

Zhan

et al. 2018

J Cellular Molecular Medi

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“…Cancer stem cells (CSCs) are usually associated with chemoresistance and cancer. High levels of SCD1 have also been observed in CSCs [17,31,45,67,68]. In lung tumor spheroids, SCD1 expression was significantly upregulated [67] and SCD1 inhibition with MF-438 reverts tumoral cisplatin resistance [45,69].…”

Section: Stearoyl-coa Desaturase (Scd)mentioning

confidence: 99%

Sterculic Acid: The Mechanisms of Action beyond Stearoyl-CoA Desaturase Inhibition and Therapeutic Opportunities in Human Diseases

Peláez

Pariente

Pérez-Sala

et al. 2020

Cells

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In many tissues, stearoyl-CoA desaturase 1 (SCD1) catalyzes the biosynthesis of monounsaturated fatty acids (MUFAS), (i.e., palmitoleate and oleate) from their saturated fatty acid (SFA) precursors (i.e., palmitate and stearate), influencing cellular membrane physiology and signaling, leading to broad effects on human physiology. In addition to its predominant role in lipid metabolism and body weight control, SCD1 has emerged recently as a potential new target for the treatment for various diseases, such as nonalcoholic steatohepatitis, Alzheimer’s disease, cancer, and skin disorders. Sterculic acid (SA) is a cyclopropene fatty acid originally found in the seeds of the plant Sterculia foetida with numerous biological activities. On the one hand, its ability to inhibit stearoyl-CoA desaturase (SCD) allows its use as a coadjuvant of several pathologies where this enzyme has been associated. On the other hand, additional effects independently of its SCD inhibitory properties, involve anti-inflammatory and protective roles in retinal diseases such as age-related macular degeneration (AMD). This review aims to summarize the mechanisms by which SA exerts its actions and to highlight the emerging areas where this natural compound may be of help for the development of new therapies for human diseases.

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“…Furthermore, a more detailed mechanism must be investigated in order to explain the effects of the combination of Sorafenib and low-dose c-Met inhibitor. It has also been demonstrated that tumor stem cells serve important roles in drug resistance in NSCLC (46). Future studies will be required to focus on the effect of this combined treatment on tumor stem cells.…”

Section: Discussionmentioning

confidence: 99%

Synergistic antitumor activity of low-dose c-Met tyrosine kinase inhibitor and sorafenib on human non-small cell lung cancer cells

Guo

Zheng

et al. 2018

Oncol Lett

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Blockade of Stearoyl-CoA-desaturase 1 activity reverts resistance to cisplatin in lung cancer stem cells

Cited by 101 publications

References 54 publications

Inhibition of stearoyl CoA desaturase‐1 activity suppresses tumour progression and improves prognosis in human bladder cancer

Inhibition of stearoyl CoA desaturase‐1 activity suppresses tumour progression and improves prognosis in human bladder cancer

Sterculic Acid: The Mechanisms of Action beyond Stearoyl-CoA Desaturase Inhibition and Therapeutic Opportunities in Human Diseases

Synergistic antitumor activity of low-dose c-Met tyrosine kinase inhibitor and sorafenib on human non-small cell lung cancer cells

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