Blockade of orexin-1 receptors in the ventral tegmental area could attenuate the lateral hypothalamic stimulation-induced potentiation of rewarding properties of morphine

Zarepour, Leila; Fatahi, Zahra; Sarihi, Abdolrahman; Haghparast, Abbas

doi:10.1016/j.npep.2014.04.003

Cited by 28 publications

(8 citation statements)

References 37 publications

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“…The NAc receives DA inputs mostly from the VTA and moderately from the ventral periaqueductal gray matter (vPAG) neurons (Hasue and Shammah-Lagnado 2002). The VTA receives orexin inputs (Hrabovszky et al 2013), and the orexin-VTA pathway and direct orexin inputs to the NAc may underlie the role of orexin in reward and addiction as well as arousal (Mukai et al 2009;Muschamp et al 2014;Zarepour et al 2014). The neural circuit underlying the NAc control of sleep-wake behavior is not known, but it is clear that the GPe is not involved as the NAc has no connection with the GPe.…”

Section: Discussionmentioning

confidence: 99%

Nigrostriatal Dopamine Acting on Globus Pallidus Regulates Sleep

Qiu¹,

Yao

Vetrivelan

et al. 2014

Cereb. Cortex

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Lesions of the globus pallidus externa (GPe) produce a profound sleep loss (∼45%) in rats, suggesting that GPe neurons promote sleep. As GPe neuronal activity is enhanced by dopamine (DA) from the substantia nigra pars compacta (SNc), we hypothesized that SNc DA via the GPe promotes sleep. To test this hypothesis, we selectively destroyed the DA afferents to the caudoputamen (CPu) using 6-hydroxydopamine and examined changes in sleep-wake profiles in rats. Rats with 80-90% loss of SNc neurons displayed a significant 33.7% increase in wakefulness (or sleep reduction). This increase significantly correlated with the extent of SNc DA neuron loss. Furthermore, these animals exhibited sleep-wake fragmentation and reduced diurnal variability of sleep. We then optogenetic-stimulated SNc DA terminals in the CPu and found that 20-Hz stimulation from 9 to 10 PM increased total sleep by 69% with high electroencephalograph (EEG) delta power. We finally directly optogenetic-stimulated GPe neurons and found that 20-Hz stimulation of the GPe from 9 to 10 PM increased total sleep by 66% and significantly increased EEG delta power. These findings elucidate a novel circuit for DA control of sleep and the mechanisms of abnormal sleep in BG disorders such as Parkinson's disease and Huntington's disease.

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Section: Discussionmentioning

confidence: 99%

Nigrostriatal Dopamine Acting on Globus Pallidus Regulates Sleep

Qiu¹,

Yao

Vetrivelan

et al. 2014

Cereb. Cortex

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“…Regardless, activation of orexins increases preference for cues indicating drug reward and reinstates extinguished drug seeking behavior (Harris et al, 2005). The OX 1 R (rather than the OX 2 R) appears to be more important in regulating drug seeking behavior and self-administration (Prince et al, 2015; Zarepour et al, 2014). Orexins also facilitate reward by attenuating the antireward effects of its cotransmitter dynorphin in the ventral tegmental area (Muschamp et al,2014).…”

Section: Orexins and Phenotypes Relevant To Mental Healthmentioning

confidence: 99%

Orexins and stress

Grafe

Bhatnagar

2018

Frontiers in Neuroendocrinology

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The neuropeptides orexins are important in regulating the neurobiological systems that respond to stressful stimuli. Furthermore, orexins are known to play a role many of the phenotypes associated with stress-related mental illness such as changes in cognition, sleep-wake states, and appetite. Interestingly, orexins are altered in stress-related psychiatric disorders such as Major Depressive Disorder and Anxiety Disorders. Thus, orexins may be a potential target for treatment of these disorders. In this review, we will focus on what is known about the role of orexins in acute and repeated stress, in stress-induced phenotypes relevant to psychiatric illness in preclinical models, and in stress-related psychiatric illness in humans. We will also briefly discuss how orexins may contribute to sex differences in the stress response and subsequent phenotypes relevant to mental health, as many stress-related psychiatric disorders are twice as prevalent in women.

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“…The role of Hcrt neurons in promoting reward seeking behaviors and cue-induced reinstatement has been established for a variety of drugs of abuse including cocaine (Borgland, Taha, Sarti, Fields, & Bonci, 2006; Boutrel et al, 2005; Harris, Wimmer, & Aston-Jones, 2005; Smith, See, & Aston-Jones, 2009; Smith, Tahsili-Fahadan, & Aston-Jones, 2010), ethanol (Mayannavar, Rashmi, Rao, Yadav, & Ganaraja, 2014, 2016; Shoblock et al, 2011; Srinivasan et al, 2012), nicotine (Dehkordi et al, 2017; Hollander, Lu, Cameron, Kamenecka, & Kenny, 2008; LeSage, Perry, Kotz, Shelley, & Corrigall, 2010; Plaza-Zabala, Martin-Garcia, de Lecea, Maldonado, & Berrendero, 2010), morphine (Georgescu et al, 2003; Harris et al, 2005; Harris, Wimmer, Randall-Thompson, & Aston-Jones, 2007; Narita et al, 2006; Sharf, Guarnieri, Taylor, & DiLeone, 2010; Sharf, Sarhan, & Dileone, 2008; Zarepour, Fatahi, Sarihi, & Haghparast, 2014), and heroin (Smith & Aston-Jones, 2012). These effects are thought to be mediated by direct projections to both components of the mesolimbic reward circuit, the ventral tegmental area (VTA) (Baimel & Borgland, 2015; Borgland, Storm, & Bonci, 2008; Borgland et al, 2006; España, Melchior, Roberts, & Jones, 2011; España et al, 2010; Hrabovszky et al, 2013; Muschamp et al, 2014; Srinivasan et al, 2012; Taslimi et al, 2012; Zarepour et al, 2014) and the nucleus accumbens (NAc) (Mayannavar et al, 2014, 2016; Mori, Kim, & Sasaki, 2011; Mukai et al, 2009; Sharf et al, 2008; Thorpe & Kotz, 2005).…”

Section: Introductionmentioning

confidence: 99%

Identification of discrete, intermingled hypocretin neuronal populations

Iyer

Essner

Klingenberg

et al. 2018

J of Comparative Neurology

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Neurons in the lateral hypothalamic area that express hypocretin (Hcrt) neuropeptides help regulate many behaviors including wakefulness and reward seeking. These neurons project throughout the brain, including to neural populations that regulate wakefulness, such as the locus coeruleus (LC) and tuberomammilary nucleus (TMN), as well as to populations that regulate reward, such as the nucleus accumbens (NAc) and ventral tegmental area (VTA). To address the roles of Hcrt neurons in seemingly disparate behaviors, it has been proposed that Hcrt neurons can be anatomically subdivided into at least two distinct subpopulations: a "medial group" that projects to the LC and TMN, and a "lateral group" that projects to the NAc and VTA. Here, we use a dual retrograde tracer strategy to test the hypotheses that Hcrt neurons can be classified based on their downstream projections and medial/lateral location within the hypothalamus. We found that individual Hcrt neurons were significantly more likely to project to both the LC and TMN or to both the VTA and NAc than would be predicted by chance. In contrast, we found that Hcrt neurons that projected to the LC or TMN were mostly distinct from Hcrt neurons that projected to the VTA or NAc. Interestingly, these two populations of Hcrt neurons are intermingled within the hypothalamus and cannot be classified into medial or lateral groups. These results suggest that Hcrt neurons can be distinguished based on their downstream projections but are intermingled within the hypothalamus.

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Blockade of orexin-1 receptors in the ventral tegmental area could attenuate the lateral hypothalamic stimulation-induced potentiation of rewarding properties of morphine

Cited by 28 publications

References 37 publications

Nigrostriatal Dopamine Acting on Globus Pallidus Regulates Sleep

Nigrostriatal Dopamine Acting on Globus Pallidus Regulates Sleep

Orexins and stress

Identification of discrete, intermingled hypocretin neuronal populations

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