Blockade of both α_1A- and α_1B-adrenergic receptor subtype signaling is required to inhibit neointimal formation in the mouse femoral artery

Abstract

A. Blockade of both ␣ 1A-and ␣1B-adrenergic receptor subtype signaling is required to inhibit neointimal formation in the mouse femoral artery.

Enhanced vascular contractility in alpha1-adrenergic receptor-deficient mice

“…In addition, all α 1 -AR blockades may be required for enhanced vascular contractility. A similar phenomenon has been observed in our previous study (Hosoda et al 2007). Single deletion of α 1A -AR or α 1B -AR subtype genes does not inhibit the neointimal formation after vascular injury in the femoral artery, while deletion of both the α 1A -AR and α 1B -AR subtype genes significantly inhibits it (Hosoda et al 2007).…”

“…Single deletion of α 1A -AR or α 1B -AR subtype genes does not inhibit the neointimal formation after vascular injury in the femoral artery, while deletion of both the α 1A -AR and α 1B -AR subtype genes significantly inhibits it (Hosoda et al 2007). These past and present observations suggest that each α 1 -AR can cooperate and compensate the receptor function when the other receptor is absent (Hosoda et al 2007;Sanbe et al 2007). …”

“…Our previous studies have recognized the contributions of each α 1 -AR subtype to NA-induced vasoconstrictive responses and they have been characterized by others using mice with targeted disruption of each α 1 -AR subtype gene (Cavalli et al 1997;Hosoda et al 2005aHosoda et al , 2007Rokosh and Simpson 2002;Sanbe et al 2007;Tanoue et al 2002). In addition, we recently demonstrated that all α 1 -AR subtype-deficient mice (α 1 -AR triple-KO mice) show a lack of in vitro responsiveness of vasoconstriction induced by NA and loss of in vivo pressor response against phenylephrine injection (non-selective α 1 -AR agonist) ).…”

Effect of nebivolol treatment during pregnancy on the genital circulation, fetal growth and postnatal development in the Wistar rat

“…Rats were placed into restraint tubes over a warming plate, to keep the body temperature at around 37 1C during the measurement, and the blood pressure tail cuff was attached. After a period of acclimation, a total of 30 cycles per animal was decided on to optimize the number of measurements, according to literature (Johns et al, 1996;Hosoda et al, 2007). The first 10 cycles were not used in the final analysis.…”

The Adrenergic System in Vascular Smooth Muscle

“…In rat aorta, both α 1A -and a 1B -adrenoceptors are involved in trophic effects [149], and in mouse femoral arteries, employing gene knockout technology, it has been demonstrated that both α 1A -and α 1B -adrenoceptors are required for neo-intimal formation (no single knockout was effective) [68].…”