“…The low clinical durability and resistance to PI3K inhibitors have repeatedly been reported in literature 14 . The activation of rescue pathways can be a part of the answer to this 44,45,65,66 . In addition, the half maximum inhibitory concentration (IC50) of BKM120 to fully block all PI3K forms as monotherapy is high, leading to cellular toxicity via disrupting microtubule dynamics 11,21,67,68 .…”