Blockade by fenspiride of endotoxin-induced neutrophil migration in the rat

Cunha, Fernando; Boukili, M. A.; Motta, Joelson I. Braga da; Vargäftig, B. Boris; Ferreira, S. H.

doi:10.1016/0014-2999(93)90503-a

Cited by 50 publications

(28 citation statements)

References 11 publications

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“…The levels of tumor necrosis factor (TNF)-a and interleukin (IL)-1b were determined by using an enzyme-linked immunosorbent assay (ELISA), as previously described [20]. ELISA results were expressed as pictograms of each cytokine per milliliter reaction mixture (pg/ml).…”

Section: Cytokine Measurementsmentioning

confidence: 99%

“…Samples of the stomach were fixed in 10 % formalin immediately after their removal for subsequent histopathological assessment. Unfixed samples were then weighed, frozen, and stored at -80°C until assayed for glutathione (GSH) levels [17], malondialdehyde (MDA) concentration [18], myeloperoxidase (MPO) activity [19], and cytokine levels [20].…”

Section: Effect Of Simvastatin On Alendronate-induced Gastric Damagementioning

confidence: 99%

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Protective Effects of Simvastatin Against Alendronate-Induced Gastric Mucosal Injury in Rats

Carvalho

Silva

et al. 2015

Dig Dis Sci

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Section: Cytokine Measurementsmentioning

confidence: 99%

Section: Effect Of Simvastatin On Alendronate-induced Gastric Damagementioning

confidence: 99%

Protective Effects of Simvastatin Against Alendronate-Induced Gastric Mucosal Injury in Rats

Carvalho

Silva

et al. 2015

Dig Dis Sci

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“…The tissue of groups was collected, homogenized, and processed (SafiehGarabedian et al, 1995;Ku et al, 2011;de Araújo Júnior et al, 2013). The detection of TNF-a and IL-1b concentrations was determined by ELISA (enzyme-linked immune sorbent assay) RayBio Õ (New Delhi, India) as earlier described by Cunha et al (1993). Briefly, 96-well microtiter plates were coated overnight at 4 C with an antibody against rat TNF-a or IL-b (100 mg/mL).…”

Section: Histological Analysismentioning

confidence: 99%

Nanoemulgel (NEG) of Ketoprofen with eugenol as oil phase for the treatment of ligature-induced experimental periodontitis in Wistar rats

et al. 2014

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Aim: The aim of the novel study was to check the efficacy of a locally applied 2%w/w nanoemulgel (NEG) of Ketoprofen (KP) in preventing the periodontitis, and was also checked NEG without KP to ensure the effect of eugenol in NEG as an oil phase. Design: For experimentally induced periodontitis, sterile silk ligatures (3/0) were placed around the crevices of the first left lower molar teeth of the male Wistar rats. During 8 weeks, all rats were fed with 10%w/v sucrose solution. The experimental assessment was carried out at 11 d after treatment of experimental periodontal disease (EPD) rats by various clinical parameters like gingival index (GI), tooth mobility (TM), alveolar bone loss (ABL), histological analysis, detection of TNF-a, and IL-1b in gingival tissue by ELISA and the roughness were measured by atomic force microscopy (AFM) in tapping modes. Results: After treatment, comparison studies with EPD were performed. NEG loaded with KP prevents significantly (p50.05) various parameters (GI, TM, and ABL), which were responsible for periodontitis. The histopathology of the periodontium showed that Group 3 (NEG loaded with KP) had a more significant reduction in inflammatory cell infiltration, alveolar bones resorption, and cementum (p50.05). In the topographical images, significant reduction in roughness of NEG loaded with KP was observed in comparison with EPD without treatment. Conclusion: The study revealed the great synergistic potential of the combined NEG of an antiinflammatory drug KP along with eugenol as the oil phase, which have potential antibacterial, analgesic, and anesthetic properties to combat periodontal disease.

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“…The tissue collected was homogenized and processed as described by SaWeh-Garabedian et al [27]. TNF-a, IL-1b and IL-10 concentrations were determined by ELISA, as described previously [28]. Briefly, microtiter plates were coated overnight at 4°C with antibody against rat TNF-a, IL-1b or IL-10 (2 g ml -1 ).…”

Section: Biodegradation Of the Membranesmentioning

confidence: 99%

Polyanionic collagen membranes for guided tissue regeneration: Effect of progressive glutaraldehyde cross-linking on biocompatibility and degradation

et al. 2010

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Blockade by fenspiride of endotoxin-induced neutrophil migration in the rat

Cited by 50 publications

References 11 publications

Protective Effects of Simvastatin Against Alendronate-Induced Gastric Mucosal Injury in Rats

Protective Effects of Simvastatin Against Alendronate-Induced Gastric Mucosal Injury in Rats

Nanoemulgel (NEG) of Ketoprofen with eugenol as oil phase for the treatment of ligature-induced experimental periodontitis in Wistar rats

Polyanionic collagen membranes for guided tissue regeneration: Effect of progressive glutaraldehyde cross-linking on biocompatibility and degradation

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