Block ionomer micellar nanoparticles from double hydrophilic copolymers, classifications and promises for delivery of cancer chemotherapeutics

Abolmaali, Samira Sadat; Tamaddon, Ali Mohammad; Salmanpour, Mohsen; Mohammadi, Samaneh; Dinarvand, Rassoul

doi:10.1016/j.ejps.2017.04.009

Cited by 30 publications

(16 citation statements)

References 106 publications

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“…It is well recognized that surfactants are able to self-assemble in water and above the critical micelle concentration (CMC), they spontaneously self-aggregate to form spherical micelles to decrease surface-free energy in an aqueous medium. Polymeric micelles have attracted enormous attention in drug delivery field because their CMC is several 1000-fold lower (<10 mg/l) than classic micelles[ 21 ] [ Figure 2 ]. Polymeric micelles are a specific class of micelles which formed from copolymers consisting of both hydrophilic and hydrophobic monomer units (block copolymer).…”

Section: Fundamental Of Polymeric Micellesmentioning

confidence: 99%

Polymeric micelles as cutaneous drug delivery system in normal skin and dermatological disorders

Makhmalzade

Chavoshy

2018

J Adv Pharm Technol Res

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The easy accessibility of skin made dermal application, one of the approaches for local drug therapy. Effectiveness of topical drug application is depended on different parameters such as skin barrier properties, physicochemical properties of drug and vehicle, and interaction between drug and its vehicle with the skin layers. In this review, an overview of skin structure and feature of polymeric micelles as topical nanocarriers is provided. We also summarized the research studies dealing with the application of polymeric micelles for cutaneous delivery. In the past decades, numerous types of nanocarriers have been widely investigated as a novel delivery approach to improve skin penetration and localization of drugs in normal skin and dermatological diseases. Polymeric micelles are one of them, with their specific ability to encapsulate hydrophilic drugs. These carriers can enhance the therapeutic efficacy and minimize the systemic side effects of the drugs. Polymeric micelles could enhance the deposition of drugs in targeted sites of the skin in the normal and dermatological diseases such as psoriasis and acne. Nevertheless, still there is a need to investigate the mechanism of action of these carriers and the fate of polymeric micelles in skin.

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Section: Fundamental Of Polymeric Micellesmentioning

confidence: 99%

Polymeric micelles as cutaneous drug delivery system in normal skin and dermatological disorders

Makhmalzade

Chavoshy

2018

J Adv Pharm Technol Res

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“…In addition, rapid SAP hydrogel degradation prior to the generation of new ECM can disrupt the mechanical stability of hydrogels. These pitfalls can be overcome by introducing composite materials such as metals, carbon nanomaterials, or synthetic polymers [ 169 ]. The impact of SAP sequences on the immune system is not well known and can vary from non-immunogenic to self-adjuvating in each design.…”

Section: Conclusion and Future Outlookmentioning

confidence: 99%

Recent advances in design and applications of biomimetic self-assembled peptide hydrogels for hard tissue regeneration

et al. 2021

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The development of natural biomaterials applied for hard tissue repair and regeneration is of great importance, especially in societies with a large elderly population. Self-assembled peptide hydrogels are a new generation of biomaterials that provide excellent biocompatibility, tunable mechanical stability, injectability, trigger capability, lack of immunogenic reactions, and the ability to load cells and active pharmaceutical agents for tissue regeneration. Peptide-based hydrogels are ideal templates for the deposition of hydroxyapatite crystals, which can mimic the extracellular matrix. Thus, peptide-based hydrogels enhance hard tissue repair and regeneration compared to conventional methods. This review presents three major self-assembled peptide hydrogels with potential application for bone and dental tissue regeneration, including ionic selfcomplementary peptides, amphiphilic (surfactant-like) peptides, and triple-helix (collagen-like) peptides. Special attention is given to the main bioactive peptides, the role and importance of self-assembled peptide hydrogels, and a brief overview on molecular simulation of self-assembled peptide hydrogels applied for bone and dental tissue engineering and regeneration.

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“…Since then, a limited number of reviews have been published relating to the self-assembly processes of DHBCs, including recent examples of polyion complex (PIC) [6] and block ionomer complex (BIC) micelles [7] (Scheme 2), as well as a recent review dedicated to the self-assembly of completely water-soluble DHBCs in aqueous medium without application of external stimuli but at high concentration [8]. The present review differs from these previous contributions as we aim at reporting and summarizing recent studies dedicated to the synthesis and the study of the behaviour of DHBCs in solution for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Double hydrophilic block copolymers self-assemblies in biomedical applications

Jundi

Buwalda

Bakkour

et al. 2020

Advances in Colloid and Interface Science

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Double-hydrophilic block copolymers (DHBCs), consisting of at least two different watersoluble blocks, are an alternative to the classical amphiphilic block copolymers and have gained increasing attention in the field of biomedical applications. Although the chemical nature of the two blocks can be diverse, most classical DHBCs consist of a bioeliminable non-ionic block to promote solubilization in water, like poly(ethylene glycol), and a second block that is more generally a pH-responsive block capable of interacting with another ionic polymer or substrate. This second block is generally non-degradable and the presence of side chain functional groups raises the question of its fate and toxicity, which is a limitation in the frame of biomedical applications. In this review, following a first part dedicated to recent examples of nondegradable DHBCs, we focus on the DHBCs that combine a biocompatible and bioeliminable non-ionic block with a degradable functional block including polysaccharides, polypeptides, polyesters and other miscellaneous polymers. Their use to design efficient drug delivery systems for various biomedical applications through stimuli-dependent self-assembly is discussed.

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Block ionomer micellar nanoparticles from double hydrophilic copolymers, classifications and promises for delivery of cancer chemotherapeutics

Cited by 30 publications

References 106 publications

Polymeric micelles as cutaneous drug delivery system in normal skin and dermatological disorders

Polymeric micelles as cutaneous drug delivery system in normal skin and dermatological disorders

Recent advances in design and applications of biomimetic self-assembled peptide hydrogels for hard tissue regeneration

Double hydrophilic block copolymers self-assemblies in biomedical applications

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