Block Copolymer Synthesis via a Combination of ATRP and RAFT Using Click Chemistry

Abstract

Block copolymer synthesis via a combination of ATRP and RAFT using click chemistry is reported for the first time. A RAFT agent with a terminal propargyl group (PTTC) was synthesized and was used to polymerize butyl acrylate and gave quantitative monomer conversion. Azide‐terminated p(tbA) was obtained by ATRP followed by reaction with sodium azide. Later, using CuBr‐PMDETA as catalyst via click chemistry, p(tBA)(ATRP) and p(BA)(RAFT) were reacted to get a block copolymer of p(tBA)(ATRP)‐b‐p(BA)(RAFT). Further, a total of 24 block copolymers were made by reacting four azido functional polymers with six propargyl functional polymers to obtain block copolymers via click chemistry. magnified image

Multiresponsive Hyaluronan‐p(NiPAAm) “Click”‐Linked Hydrogels

“…This should be attributed mainly to the stoichiometric unbalance of the two functionalities participating to each click, evaluable in about a mismatch of about 20–30%, caused by the ex post determination of the molecular weights of the Pp(NiPAAm)P chains. Other factors contributing to these findings are i) the possible loss of material during transfers, principally with very soft hydrogels, ii) a 10% of inactive alkyne groups due to the absence of a protecting agent in the RAFT p(NiPAAm) polymerization, iii) intrachain loops and dangling chains.…”

Living Radical Polymerization by the RAFT Process – A Third Update

“…G [415] MMA [415] St [415] MA [415] tBA [415] NIPAm [415] DMAm [415] MA-b-tBA [415] MA-bDMAm [415] G* [388,416] 310 [417] St [418] 4VP [388] BA [416] tBA [416] EHA [416] LA [416] PEGA [416] NIPAm [267] 137…”

“…[416] NMP-RAFT RAFT end-group transformation by addition-fragmentationcoupling can be performed in the presence of a nitroxide to yield an alkoxyamine chain end. [619] This enables macro-RAFT agents to be transformed to alkoxyamines for use in NMP.…”

Preparation of hyperbranched polystyrene-g-poly(N-isopropylacrylamide) copolymers and its application to novel thermo-responsive cell culture dishes

“…A bright yellow solid was collected by evaporation and 4.28 g (yield: 43%) of the final solid product was obtained after silica gel column chromatography using a 1: 4 mixture of ethyl acetate and hexane. 1 Propargyl-terminated CTA was prepared by the following reported procedure [17]. Propargyl alcohol (1.51 g, 26.9 mmol), CTA (4.82 g, 13.2 mmol) and DMAP (1.71 g, 14.0 mmol) were dissolved in dichloromethane (240 mL) and the solution was cooled to 0 C. After stirring for 30 min, DCC (2.75 g, 13.3 mmol) dissolved in dichloromethane (24 mL) was added slowly and the mixture was stirred at room temperature for 24 h. The white by-product was filtered off and the solvent was removed.…”