Block-copolymer-stabilized iodinated emulsions for use as CT contrast agents

Vries, Anke de; Custers, Erica; Lub, Johan; Bosch, Sandra van den; Nicolay, Klaas; Grüll, Holger

doi:10.1016/j.biomaterials.2010.04.056

Cited by 124 publications

(105 citation statements)

References 24 publications

Supporting

Mentioning

104

Contrasting

Order By: Relevance

“…Research essentially focuses [213,214] on the incorporation of iodinated organic compounds into NPs, with designs ranging from emulsions, [215][216][217][218] liposomes, [214,[219][220][221][222][223] and lipoproteins, [224,225] to insoluble nano objects, [214,[226][227][228] and polymeric NPs, [215,[229][230][231][232][233]; many of them have been successfully applied in vivo [28,56]. The purpose of these nanomaterials is to locally increase iodine concentrations, Some multimodal nanoparticles were doped with an iodinated compound and used to enhance X-ray contrast [216,224,234,235] as discussed in later on in the review.…”

Section: Iodinated Nanoparticlesmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville³

2016

Nano Online

View full text Add to dashboard Cite

The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in synthesis protocol and characterization of these materials whereas toxicological issues are sometimes incomplete. Nanoparticle-based contrast agents tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of 2 imaging modalities. Multimodal nanoparticles (NPs) are much more efficient than conventional molecular-scale contrast agents. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides specific applications for classical imaging, (MRI, PET, CT, US, PAI) are also mentioned less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA).Perspectives on multimodal theranostic NPs and their potential for clinical advances are also mentioned.

show abstract

Section: Iodinated Nanoparticlesmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville³

2016

Nano Online

View full text Add to dashboard Cite

show abstract

“…Other CT molecular imaging agents contain bismuth sulfide, as well as composite ceramics containing iron oxide and lanthanide materials. Most CT molecular contrast agents are designed to incorporate a maximum number of x-ray-absorbing atoms into a nanoparticle, with designs ranging from emulsions (71)(72)(73) (Fig 6), liposomes (74), and lipoproteins (42) to polymeric nanoparticles (75,76). A key feature of many of these nanoparticle designs is their pharmacokinetics, which are often markedly different than those of small iodinated molecules in clinical use.…”

Section: Principles Of Molecular Ct Contrast Agentsmentioning

confidence: 99%

Molecular Body Imaging: MR Imaging, CT, and US. Part I. Principles

Kircher¹,

Willmann²

2012

Radiology

186

154

View full text Add to dashboard Cite

“…This property has been utilized for making X-ray images clearer, or taking high contrast images. Various iodine compounds have been thus far proposed as X-ray contrast agents [1][2][3][4][5], and several iodine compounds are commercially available. The iodine compounds, however, cannot be used for patients, in which adverse events as allergic reactions may be provoked by the iodine compounds [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Preparation of AgI/Silica/Poly(Ethylene Glycol) Nanoparticle Colloid Solution and X-Ray Imaging Using It

et al. 2013

View full text Add to dashboard Cite

This work performed X-ray imaging of mouse by using aqueous colloid solution of AgI nanoparticles coated with silica (AgI/ SiO 2 ) and then surface-modified with poly(ethylene glycol) (PEG) (AgI/SiO 2 /PEG). A colloid solution of AgI nanoparticles was prepared by mixing silver perchlorate and potassium iodide in water. The AgI nanoparticles were surface-modified with 3-mercaptopropyltrimethoxysilane and then were silica-coated by a sol-gel reaction between tetraethylorthosilicate and H 2 O catalyzed with NaOH in ethanol. The AgI/SiO 2 particle surface was modified with PEG by using methoxy PEG silane (CH 3 O(CH 2 CH 2 O) CH 2 CONHC 3 H 6 Si(OC 2 H 5 ) 3 ). The AgI/SiO 2 /PEG colloid solution revealed a computed tomography value as high as 1343.6 HU at an iodine concentration of 0.1 M, which was higher than a commercial X-ray contrast agent with the same iodine concentration. Tissues of mouse could be imaged by injecting the concentrated colloid solution into them.

show abstract

Block-copolymer-stabilized iodinated emulsions for use as CT contrast agents

Cited by 124 publications

References 24 publications

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Molecular Body Imaging: MR Imaging, CT, and US. Part I. Principles

Preparation of AgI/Silica/Poly(Ethylene Glycol) Nanoparticle Colloid Solution and X-Ray Imaging Using It

Contact Info

Product

Resources

About