Block copolymer [(<scp>l</scp>-GluA-5-BE)-<i>b</i>-(<scp>l</scp>-AspA-4-BE)]-based nanoflower capsules with thermosensitive morphology and pH-responsive drug release for cancer therapy

Amgoth, Chander; Chen, Shuai; Malavath, Tirupathi; Tang, Guping

doi:10.1039/d0tb01647k

Cited by 13 publications

(6 citation statements)

References 42 publications

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“…Finally, we also tested the potential effects of pH and temperature on the synthesized FM. Interestingly, a reduction in the whole particle size was observed by scanning electron microscopy as the pH was decreased but the temperature was increased [37] (figures S1 and S2).…”

Section: Resultsmentioning

confidence: 98%

Synthesis of Fe₃O₄ core/MIL-100(Fe) shell nanocomposites for tumor chemo-ferroptosis combination therapy and MR imaging

Jiang,

Wang,

et al. 2024

Biomed. Mater.

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The application of both chemotherapy and ferrotherapy together has shown great potential in increasing the effectiveness of cancer treatment. To achieve such a combination, we herein have synthesized Fe3O4 core/MIL-100(Fe) shell nanocomposites (FM) that can be used for tumor chemo-ferroptosis combination therapy. In these nanocomposites, the anticancer drug 10-hydroxycamptothecin (HCPT) and iron ions could be co-delivered into tumors. On one hand, the released HCPT molecules can enter the cell nucleus and bind with DNA, resulting in induction of tumor cell apoptosis. On the other hand, the iron ions could react with H2O2 leading to the production of ROS through the Fenton reaction, thereby triggering tumor cell ferroptosis. Consequently, a superior antitumor effect was achieved through the combination of the apoptosis and ferroptosis. Additionally, the Fe3O4 core endowed FM with high performance for magnetic resonance imaging (MRI), which further provided novel avenues for imaging guidance therapy. Therefore, we anticipate that application of these nanocomposites could have great potential in the field of tumor therapy.

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Section: Resultsmentioning

confidence: 98%

Synthesis of Fe₃O₄ core/MIL-100(Fe) shell nanocomposites for tumor chemo-ferroptosis combination therapy and MR imaging

Jiang,

Wang,

et al. 2024

Biomed. Mater.

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“…The drug (gene) loading was conducted with the microencapsulation sonication method. − Owing to the nest-type structure and cationic property, CAAu NPs showed high encapsulation capacity for codelivery. We first determined their loading capacity (LC) and encapsulation efficiency (EE) on GFT using high-performance liquid chromatography (HPLC) with UV–vis detection at 330 nm (Figure A).…”

Section: Results and Discussionmentioning

confidence: 99%

“…Under acidic conditions (pH 6.2), the drug release was accelerated, with the released GFT and miR125b increasing to 82.7 ± 3.2 and 74.7 ± 8.4%, respectively. The increased release was attributed to the attenuation of Au...OH and Au...NH coupling under acidic conditions, 33,34 resulting in the collapse of the nest-type construction and thus facilitating the pH-responsive drug release. S15, Supporting Information: fluorescence microscope images of the internalization of RhoB@CAAu NPs).…”

Section: Introductionmentioning

confidence: 99%

Metal (Au)-Decorated Chitosan-l-Arginine Polymeric Vector for Codelivery of Gefitinib and miR125b for Lung Cancer Therapy

Amgoth

Wang

et al. 2022

ACS Appl. Polym. Mater.

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The progression of lung cancer is highly associated with the aberrant activation of epidermal growth factor receptor (EGFR) tyrosine kinase and the positive feedback loop between cancer cells and tumor-associated macrophages (TAMs). Hence, we use chitosan (CS) as a backbone and L-Arginine (L-Arg) as lateral chains to synthesize a biocompatible copolymer [(CS)-co-(L-Arg)]. With the electrostatic coupling between Au particles and [(CS)-co-(L-Arg)], the copolymer was further fabricated into [(CS)-co-(L-Arg)]-(AuNPs) nanoparticles with a nest-type perforated structure (CAAu NPs). Owing to the perforated structure and cationic property, CAAu NPs exhibit a high capacity for coloading of gefitinib (GFT) and miR125b, forming GFT-miR125b@CAAu nanomedicine. GFT-miR125b@CAAu shows a pulmonary-anchoring advantage, which is attributed to the mucoadhesion of the CS backbone. Meanwhile, L-Arg residues play a biomimetic role, which endows GFT-miR125b@CAAu with efficient internalization by cancer cells through Arg transportermediated endocytosis. Within the acidic tumor microenvironment, the electrostatic bonding of GFT-miR125b@CAAu cleaves, which facilitates pH-responsive release of GFT and miR125b. By combination of EGFR blocking and miR125b augmenting, GFT-miR125b@CAAu nanomedicine not only inhibits cancer cell survival but also deactivates protumoral TAMs, implementing a combination therapy against lung cancer.

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“…The tumor microenvironment is featured by the weakly acidity with a pH value of 6.5-6.8 [49], which facilitates the detachment of the PEG shells cross-linked by Schiff base . The bond is stable in the blood circulation and physiological environment (pH 7.4) but cracked in the tumor microenvironment.…”

Section: Tumor Microenvironment Responsive Peg Detachment Of Peg-c-(b...mentioning

confidence: 99%

Tumor microenvironment and redox dual stimuli-responsive polymeric nanoparticles for the effective cisplatin-based cancer chemotherapy

Jia¹,

Huan²,

Wang³

et al. 2022

Nanotechnology

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The serious side effects of cisplatin hindered its clinical application and the nanotechnology might be the potential strategy to address the limitation. However, rapid clearance in the blood circulation and ineffective controlled drug release from nanocarriers hamper the therapeutic efficacy of the nano-delivery system. We constructed a tumor microenvironment and redox dual stimuli-responsive nano-delivery system PEG-c-(BPEI-SS-Pt) by cross-linking the disulfide-containing polymeric conjugate BPEI-SS-Pt with the dialdehyde group-modified PEG2000 via Schiff base. After optimized the cross-linking time, 72 h was selected to get the nano-delivery system. 1H NMR and drug release assays showed that under the acidic tumor microenvironment (pH6.5-6.8), the Schiff base can be broken and detached the PEG cross-linked outer shells, displaying the capability to release the drugs with a sequential pH- and redox-responsive manner. Moreover, PEG-c-(BPEI-SS-Pt) showed more effective anti-tumor therapeutic efficacy in vivo with no significant side effects when compared with the drug of cisplatin used in the clinic. This strategy highlights a promising platform with the dual stimuli-responsive profile to achieve better therapeutic efficacy and minor side effects for platinum-based chemotherapy.

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Block copolymer [(l-GluA-5-BE)-b-(l-AspA-4-BE)]-based nanoflower capsules with thermosensitive morphology and pH-responsive drug release for cancer therapy

Abstract: Herein, the synthesis of an amino-acid-based di-block copolymer (di-BCP) in-between an l-glutamic acid-5-benzyl ester and L-aspartic acid-4-benzyl ester [(l-GluA-5-BE)-b-(l-AspA-4-BE)] has been reported.

Cited by 13 publications

References 42 publications

Synthesis of Fe₃O₄ core/MIL-100(Fe) shell nanocomposites for tumor chemo-ferroptosis combination therapy and MR imaging

Synthesis of Fe₃O₄ core/MIL-100(Fe) shell nanocomposites for tumor chemo-ferroptosis combination therapy and MR imaging

Metal (Au)-Decorated Chitosan-l-Arginine Polymeric Vector for Codelivery of Gefitinib and miR125b for Lung Cancer Therapy

Tumor microenvironment and redox dual stimuli-responsive polymeric nanoparticles for the effective cisplatin-based cancer chemotherapy

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Block copolymer [(l-GluA-5-BE)-b-(l-AspA-4-BE)]-based nanoflower capsules with thermosensitive morphology and pH-responsive drug release for cancer therapy

Abstract: Herein, the synthesis of an amino-acid-based di-block copolymer (di-BCP) in-between an l-glutamic acid-5-benzyl ester and L-aspartic acid-4-benzyl ester [(l-GluA-5-BE)-b-(l-AspA-4-BE)] has been reported.

Cited by 13 publications

References 42 publications

Synthesis of Fe3O4 core/MIL-100(Fe) shell nanocomposites for tumor chemo-ferroptosis combination therapy and MR imaging

Synthesis of Fe3O4 core/MIL-100(Fe) shell nanocomposites for tumor chemo-ferroptosis combination therapy and MR imaging

Metal (Au)-Decorated Chitosan-l-Arginine Polymeric Vector for Codelivery of Gefitinib and miR125b for Lung Cancer Therapy

Tumor microenvironment and redox dual stimuli-responsive polymeric nanoparticles for the effective cisplatin-based cancer chemotherapy

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Synthesis of Fe₃O₄ core/MIL-100(Fe) shell nanocomposites for tumor chemo-ferroptosis combination therapy and MR imaging

Synthesis of Fe₃O₄ core/MIL-100(Fe) shell nanocomposites for tumor chemo-ferroptosis combination therapy and MR imaging