Block copolymer micelles for delivery of cancer therapy: Transport at the whole body, tissue and cellular levels

Mikhail, Andrew S.; Allen, Christine

doi:10.1016/j.jconrel.2009.04.010

Cited by 303 publications

(229 citation statements)

References 112 publications

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“…Therefore, the introduction of anionic carboxyl group into non-ionic copolymers does not inhibit their micelle formation but prevents further micelle aggregation to the microphase. This effect is of particular interest for improving micellar and pharmacokinetic properties of amphiphilic copolymers of EO and PO as drug carriers and enhancers [24,26].…”

Section: Micelle-forming Properties Of Oxidized Copolymersmentioning

confidence: 99%

Non-invasive topical drug delivery to spinal cord with carboxyl-modified trifunctional copolymer of ethylene oxide and propylene oxide

Kamalov

Lavrov

Yergeshov

et al. 2016

Colloids and Surfaces B: Biointerfaces

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In this study the effect of oxidative modification on micellar and drug deliveryproperties of copolymers of ethylene oxide (EO) and propylene oxide (PO) wasinvestigated. Carboxylated trifunctional copolymers were synthesized in the reaction withchromium oxide (VI). We found that carboxylation significantly improved the uniformityand stability of polymeric micelles by inhibiting the microphase transition. Thecytotoxicity of copolymers was studied in relation to their aggregative state on two celltypes (cancer line vs. primary fibroblasts). The accumulation of rhodamine 123 inneuroblastoma SH-SY5Y cells was dramatically increased in the presence of the oxidizedblock copolymer with the number of PO and EO units of 83.5 and 24.2, respectively. Thecopolymer was also tested as an enhancer for topical drug delivery to the spinal cordwhen applied subdurally. The oxidized copolymer facilitated the penetration ofrhodamine 123 across spinal cord tissues and increased its intraspinal accumulation.These results show the potential of using oxidized EO/PO based polymers for noninvasivedelivery of protective drugs after spinal cord injury

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Section: Micelle-forming Properties Of Oxidized Copolymersmentioning

confidence: 99%

Non-invasive topical drug delivery to spinal cord with carboxyl-modified trifunctional copolymer of ethylene oxide and propylene oxide

Kamalov

Lavrov

Yergeshov

et al. 2016

Colloids and Surfaces B: Biointerfaces

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“…Small molecule inhibitors, vitamins, hormones and antibodies can enhance drug delivery and therapeutic effects. However, "active" targeting does not necessarily mean more efficient accumulation of drug or DDS in tumours [124]. Current drugs or DDS actually cannot guide themselves to the target.…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Supramolecular nanoscale assemblies for cancer diagnosis and therapy

Coelho

Pereira

Juzeniene

et al. 2015

Journal of Controlled Release

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Nanocarriers based on polymers, metals and lipids have been extensively developed for cancer therapy and diagnosis due to their ability to enhance drug accumulation in cancer cells and decrease undesired drug toxicity in healthy tissues. Overcoming multidrug resistance by designing proper drug nanocarriers will improve outcome of existing oncologic treatments such as chemotherapy or radiotherapy. In this article the relation between physicochemical properties and capacity of a nanosystem to deliver therapeutic agents into pathological sites is discussed. Most promising examples of drug delivery systems are reviewed, and, in particular, the design of a carbohydrate based matrix with entrapped gold nanoparticles is highlighted.

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“…A hydrophobic core, being able to incorporate various hydrophobic drugs, is surrounded by a hydrophilic corona, capable of water solubility and biocompatibility of the micelles. 8,9 Many examples of hybrid block copolymers composed of a nano-biological segment, proteins, and one or two homopolypeptide sequences were reported. [10][11][12] Recently, the interest of utilizing the peptide-polymer hybrid materials (PPs) increased as building blocks, which could be assembled into nano-structures in selective solvents.…”

Section: Introductionmentioning

confidence: 99%

Solid Phase Synthesis of Lysine-exposed Peptide-Polymer Hybrids by Atom Transfer Radical Polymerization

Ha¹,

Kim²,

Kim³

et al. 2014

Polymer Korea

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Recently, the peptide(or protein)-polymer hybrid materials (PPs) were sought in many research areas as potential building blocks for assembling nanostructures in selective solvents. In PPs, the facile routes of preparing well-defined peptide-polymer bio-conjugates and their specific activities in various applications are important issues. Our strategy to prepare the peptide-polymer hybrid materials was to combine atom transfer radical polymerization (ATRP) method with solid phase peptide synthesis. The standard solid phase peptide synthesis method was employed to prepare the PYGK (proline-tyrosine-glycine-lysine) peptide. PYGK is an analogue peptide, PFGK (proline-phenylalanine-glycine-lysine), which interacted with plasminogen in fibrinolysis. The peptide and the peptide-initiator were characterized with MALDI-TOF mass spectrometry and 1 H NMR spectrometer. The peptide-polymer, pSt-PYGK was characterized by GPC, IR, 1 H NMR spectrometer and TLC. Spherical micellar aggregates were determined by TEM and SEM. Current synthesis methodology suggested opportunities to create the well-defined peptide-polymer hybrid materials with specific binding activity.

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Block copolymer micelles for delivery of cancer therapy: Transport at the whole body, tissue and cellular levels

Cited by 303 publications

References 112 publications

Non-invasive topical drug delivery to spinal cord with carboxyl-modified trifunctional copolymer of ethylene oxide and propylene oxide

Non-invasive topical drug delivery to spinal cord with carboxyl-modified trifunctional copolymer of ethylene oxide and propylene oxide

Supramolecular nanoscale assemblies for cancer diagnosis and therapy

Solid Phase Synthesis of Lysine-exposed Peptide-Polymer Hybrids by Atom Transfer Radical Polymerization

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