Block Copolymer Micelles and Vesicles for Drug Delivery

Robertson, J. David; Patikarnmonthon, Nisa; Joseph, Adrian; Battaglia, Giuseppe

doi:10.1002/9781118747896.ch6

Cited by 11 publications

(6 citation statements)

References 89 publications

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“…47,48,51 Although shape is known to be an important factor in the design of a nanovector, the vast majority of engineered nanovectors are spherical. 52 While wormlike micelles can be formed from amphiphilic block copolymers by controlling the polymer packing parameter, 53 these solid micellular structures do not contain an aqueous core that enables the encapsulation of water-soluble molecules. 54 Carbon nanotubes have received a lot of attention as drug delivery carriers, and although visually carbon nanotubes appear similar in structure to tubular polymersomes, they have very different properties.…”

Section: Resultsmentioning

confidence: 99%

“…Although shape is known to be an important factor in the design of a nanovector, the vast majority of engineered nanovectors are spherical . While worm-like micelles can be formed from amphiphilic block copolymers by controlling the polymer packing parameter, these solid micellular structures do not contain an aqueous core that enables the encapsulation of water-soluble molecules .…”

Section: Resultsmentioning

confidence: 99%

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pH-Sensitive Tubular Polymersomes: Formation and Applications in Cellular Delivery

et al. 2014

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Optimizing the shape of a nanovector influences its interaction with a cell and determines the internalization kinetics. Block copolymer amphiphiles self-assemble into monodisperse structures in aqueous solutions and have been explored extensively as drug delivery vectors. However, the structure of self-assembled block copolymers has mainly been limited to spherical vesicles or spherical and worm-like micelles. Here we show the controlled formation and purification of tubular polymersomes, long cylindrical vesicles. Tubular polymersomes are purified from other structures, and their formation is manipulated by incorporating the biocompatible membrane components cholesterol and phospholipids. Finally we show that these tubular polymersomes have different cellular internalization kinetics compared with spherical polymersomes and can successfully encapsulate and deliver fluorescent bovine serum albumin protein intracellularly.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

pH-Sensitive Tubular Polymersomes: Formation and Applications in Cellular Delivery

et al. 2014

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“…Membrane mimics have been developed from phospholipids, the most abundant components of biological membranes, , but recently it has been shown that amphiphilic block copolymers are better candidates for generating membrane models, since they surpass membranes based on phospholipids in terms of stability, permeability, and flexibility, due to their higher molecular weights . A great advantage of amphiphilic block copolymers is the availability of a wide choice of monomers and the possibility of varying the length of both the hydrophilic and hydrophobic blocks to design macromolecules with desired properties. − A promising alternative for producing membranes with triggered properties is to develop hybrid systems composed of mixed lipids and amphiphilic block copolymers. , This combination allows the generation of desired properties for materials, by combining the robustness of amphiphilic block copolymers with the biocompatibility of phospholipids . In this respect, the presence of thicker amphiphilic block copolymer domains in mixed films influences the stability and permeability of such hybrid systems .…”

Section: Introductionmentioning

confidence: 99%

Hybrid Polymer–Lipid Films as Platforms for Directed Membrane Protein Insertion

et al. 2015

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Hybrids composed of amphiphilic block copolymers and lipids constitute a new generation of biological membrane-inspired materials. Hybrid membranes resulting from self-assembly of lipids and polymers represent adjustable models for interactions between artificial and natural membranes, which are of key importance, e.g., when developing systems for drug delivery. By combining poly(dimethylsiloxane)-block-poly(2-methyl-2-oxazoline) amphiphilic copolymers (PDMS-b-PMOXA) with various phospholipids, we obtained hybrid films with modulated properties and topology, based on phase separation, and the formation of distinct domains. By understanding the factors driving the phase separation in these hybrid lipid-polymer films, we were able to use them as platforms for directed insertion of membrane proteins. Tuning the composition of the polymer-lipids mixtures favored successful insertion of membrane proteins with desired topological distributions (in polymer or/and lipid regions). Controlled insertion and location of membrane proteins in hybrid films make these hybrids ideal candidates for numerous applications where specific spatial functionality is required.

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“…Size and shape are important parameters for nanoparticle-based drug delivery1, that control the kinetics of internalisation2, biodistribution3, cellular membrane deformability4, and cargo loading efficiency5. It has been shown that smaller nanoparticles escape natural body clearance mechanisms ( i.e.…”

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Purification of Nanoparticles by Size and Shape

Robertson

Rizzello

Avila-Olias

et al. 2016

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Producing monodisperse nanoparticles is essential to ensure consistency in biological experiments and to enable a smooth translation into the clinic. Purification of samples into discrete sizes and shapes may not only improve sample quality, but also provide us with the tools to understand which physical properties of nanoparticles are beneficial for a drug delivery vector. In this study, using polymersomes as a model system, we explore four techniques for purifying pre-formed nanoparticles into discrete fractions based on their size, shape or density. We show that these techniques can successfully separate polymersomes into monodisperse fractions.

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Block Copolymer Micelles and Vesicles for Drug Delivery

Cited by 11 publications

References 89 publications

pH-Sensitive Tubular Polymersomes: Formation and Applications in Cellular Delivery

pH-Sensitive Tubular Polymersomes: Formation and Applications in Cellular Delivery

Hybrid Polymer–Lipid Films as Platforms for Directed Membrane Protein Insertion

Purification of Nanoparticles by Size and Shape

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