Block Allograft Technique versus Standard Guided Bone Regeneration: A Randomized Clinical Trial

Amorfini, Leonardo; Migliorati, Marco; Signori, Alessio; Silvestrini-Biavati, Armando; Benedicenti, Stefano

doi:10.1111/cid.12040

Cited by 49 publications

(90 citation statements)

References 34 publications

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“…Radiographic data emphasized the high volume stability of allogenic bone blocks, which has been demonstrated to be comparable to autologous bone grafts in several studies . Horizontal resorption rates were 7% and 20% and vertical resorption rates 3% and 12% in the first and second quadrant, resulting in 3.94 mm and 4.54 mm horizontal and 4.35 mm and 2.76 mm vertical bone gain, respectively (Figure ; Table ) . The more pronounced loss in bone volume within the second quadrant could be associated to a bigger defect size, as the edentulous space here spanned three teeth, whereas only two teeth were missing in the first quadrant.…”

Section: Discussionmentioning

confidence: 62%

“…These situations often require massive bone grafts such as blocks or cortical struts. While processed allogeneic bone grafts have been demonstrated to function analogous to autologous bone block transplants with comparable clinical results, performance of other bone substitutes in the form of blocks in contemporary literature is rather limited …”

Section: Introductionmentioning

confidence: 99%

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Bilateral maxillary augmentation using CAD/CAM manufactured allogenic bone blocks for restoration of congenitally missing teeth: A case report

Blume

Donkiewicz

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et al. 2019

J Esthet Restor Dent

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Objective Various biomaterials have been successfully applied in alveolar bone regeneration, however, the reconstruction of extensive osseous defects remains challenging and is often unfeasible with granular grafting materials. Several studies have outlined allogenic bone blocks as valid alternative to autologous block grafting. Clinical Considerations In this report, we demonstrate the regeneration of two large osseous defects in the maxilla with allogenic bone blocks made from human donor bone. The bone blocks were customized using the CAD/CAM technology in order to enable the insertion of four dental implants. Conclusions Both blocks perfectly matched the defect geometry, showed limited resorption, led to the formation of sufficient amounts of mineralized bone in both horizontal and vertical dimensions and enabled the installation of implants according to the treatment plan. The implementation of innovative technologies for individualization of allogenic bone blocks simplifies the restoration of complex and extensive osseous defects and poses great benefits for both practitioners and patients. Clinical Significance The here presented procedure demonstrates the successful regeneration of two extensive osseous defects in a patient suffering from hypodontia using two CAD/CAM manufactured allogenic bone blocks, rendering the procedure far less invasive as compared to guided bone regeneration carried out with autologous transplants. Furthermore, to the best of our knowledge, this is the first case report that radiographically demonstrates the new formation of a cortical bone layer following block grafting with solely cancellous bone blocks.

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Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Bilateral maxillary augmentation using CAD/CAM manufactured allogenic bone blocks for restoration of congenitally missing teeth: A case report

Blume

Donkiewicz

Back

et al. 2019

J Esthet Restor Dent

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“…At the end, 189 articles were included. Overall, 55 studies were categorized at level I 12–66 . Twenty‐six were level II, 67–92 nine were level III, 93–101 46 were level IV S1‐S46 (see references in http://www.joponline.org/doi/suppl/10.1902/jop.2016.150512/suppl_file/150512_supapp1.pdf and http://www.joponline.org/doi/suppl/10.1902/jop.2016.150512/suppl_file/150512_supapp2.pdf in online Journal of Periodontology ), and 53 were level V S47‐S99 (see references in http://www.joponline.org/doi/suppl/10.1902/jop.2016.150512/suppl_file/150512_supapp1.pdf and http://www.joponline.org/doi/suppl/10.1902/jop.2016.150512/suppl_file/150512_supapp3.pdf in online Journal of Periodontology ).…”

Section: Resultsmentioning

confidence: 99%

“…Some of these studies used more than one type of xenograft and/or other types of grafts (see http://www.joponline.org/doi/suppl/10.1902/jop.2016.150512/suppl_file/150512_suptab3.pdf in online Journal of Periodontology ). Twenty‐four 13,16,17,27,35‐50,54,64‐66 of 90 studies were considered level I of evidence. These level I studies are summarized in http://www.joponline.org/doi/suppl/10.1902/jop.2016.150512/suppl_file/150512_suptab4.pdf in online Journal of Periodontology .…”

Section: Resultsmentioning

confidence: 99%

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Usage of Bone Replacement Grafts in Periodontics and Oral Implantology and Their Current Levels of Clinical Evidence — A Systematic Assessment

Salem

Natto

Elangovan

et al. 2016

Journal of Periodontology

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Collagen membranes of dermal and pericardial origin—In vivo evolvement of vascularization over time

Dau

Volprich

Grambow

et al. 2020

J Biomedical Materials Res

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Aim of the study was to compare the evolvement of vascularization over time of collagen membranes (CMs) of dermal and pericardial origin in an in vivo animal study. Twentyeight mice underwent implantation of three commercially available CM derived from porcine dermis (homogenous structure: CM1 (Control 1) and bilayer structure: CM2 [Control 2]), from porcine pericardium (CM3; Test 1) as well as CM3 sprayed with silica-enhanced nanostructured hydroxyapatite (CM4, Test 2). After 3, 6, 9, and 12 days, intravital fluorescence microscopy was conducted for determination of capillary diameter, density, flow, and length. At Day 12, samples were examined immunohistologically for expression of fibroblast growth factor receptor 4 (FGFR4), CD11b, CD68, αSMA, and CD34. In all CM, intravital fluorescence microscopy over time showed increasing values for all parameters with the highest levels in CM4 and the lowest values in CM1. Significant lower amounts of FGFR4, CD11b, and CD68 were detected in CM4 when compared to CM2 (p < .05). In contrast to CM3, lower values of αSMA and higher numbers of CD34 positive-marked vessels were observed in CM4 (p < .05). In conclusion, dermal bilayer as well as pericardial CM seem to have a higher vascularization rate than dermal homogenous CM. Additional coating of pericardial CM with a silica-enhanced hydroxyapatite increases the speed of vascularization as well as biological remodeling processes.

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Block Allograft Technique versus Standard Guided Bone Regeneration: A Randomized Clinical Trial

Abstract: The block allograft and the standard regenerative procedure showed similar results in terms of regenerated bone volume after 1 year of functional loading. The rhPDGF-BB positively influenced soft-tissue healing.

Cited by 49 publications

References 34 publications

Bilateral maxillary augmentation using CAD/CAM manufactured allogenic bone blocks for restoration of congenitally missing teeth: A case report

Bilateral maxillary augmentation using CAD/CAM manufactured allogenic bone blocks for restoration of congenitally missing teeth: A case report

Usage of Bone Replacement Grafts in Periodontics and Oral Implantology and Their Current Levels of Clinical Evidence — A Systematic Assessment

Collagen membranes of dermal and pericardial origin—In vivo evolvement of vascularization over time

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