BLOC1S1 control of vacuolar organelle fidelity modulates TH2 cell immunity and allergy susceptibility
Rahul Sharma,
Kaiyuan Wu,
Kim Han
et al.
Abstract:The levels of biogenesis of lysosome organelles complex 1 subunit 1 (BLOC1S1) control mitochondrial and endolysosome organelle homeostasis and function. Reduced fidelity of these vacuolar organelles is increasingly being recognized as important in instigating cell-autonomous immune cell activation. We reasoned that exploring the role of BLOC1S1 in CD4+ T cells, may further advance our understanding of regulatory events linked to mitochondrial and/or endolysosomal function in adaptive immunity. Transcript level… Show more
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