Bloc auriculoventriculaire complet chez un patient traité par interféron alpha : une complication rare du traitement de l’hépatite C

Roche, Nicolas-Charles; Pelletier, Philippe; Kerebel, Sébastien; Gil, Jean-Marie; Héno, P.; Fourcade, Laurent

doi:10.1016/j.lpm.2010.10.024

Cited by 4 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is a wide variety of adverse effects due to the use of interferon alpha 2a, including flu-like syndrome (unusual tiredness, fever, chills, muscle aches, and joint pain), injection site reaction (redness, pain at the site of injection), proneness to serious infections, new or worsening autoimmune disease 5– 7 , myelosuppression 8, 9 , depression, suicide, suicidal thoughts, and cardiovascular problems 10, 11 such as hypotension or hypertension, arrhythmia and myocardial infarction. Patients may also suffer from nausea, vomiting, loss of appetite, diarrhea, cough, dry mouth, dizziness, vertigo, sweating, itching, hair loss, fatigue, abdominal pain, constipation, sore throat, insomnia 12 , anxiety and numbness.…”

Section: Discussionmentioning

confidence: 99%

Bell’s palsy during interferon alpha 2a treatment in a case with Behçet uveitis

Yalçındağ

Alay

2013

F1000Res

View full text Add to dashboard Cite

Purpose: To present a case who developed Bell’s palsy while using interferon alpha 2a for Behçet uveitis. Methods: A patient with Behçet disease presented with decreased vision in his right eye. Ophthalmic examination, fundus fluorescein angiography and optical coherence tomography were performed. After developing facial paralysis while on interferon therapy, the patient was referred to our neurology service for differential diagnosis and treatment. Results: Examination of right eye revealed panuveitis with branch retinal vein occlusion, so high dose steroids were prescribed. In three days there was no improvement in terms of vitreous inflammation and so steroids were replaced with interferon. At the seventh month, patient experienced a facial paralysis. After eliminating other causes, including viral infections, trauma, cold exposure and neurological evaluation with cranial MRI, the patient was diagnosed to have Bell’s palsy by a neurologist. Interferon was replaced with mycophenolate mofetil and the Bell’s palsy was treated with oral steroids. Conclusion: It is important to be alert to both common and rare complications while treating with interferon.

show abstract