Blisters and pustules in the newborn

Congenital self‐healing histiocytosis (Hashimoto–Pritzker)

“…Differential diagnosis must be performed with regard to other vesiculopustular eruptions of the newborn including neonatal pustular melanosis, congenital candidiasis, perinatal listeria monocytogenes or herpes simplex infection, neonatal varicella, erythema toxicum neonatal, infantile acropustulosis, incontinentia pigmenti, and eosinophilic pustular folliculitis. Gram stain, KOH, and Tzanck preparation and bacterial, viral, and fungal cultures help in the diagnosis, but a skin biopsy specimen is necessary to confirm it 14 . Other entities that must be differentiated from CSHLCH include erythropoiesis dermica, neonatal disseminated hemangiomatosis, and congenital leukemia.…”

Focal Bacterial Infections

“…Cutaneous infections caused by many other bacteria are discussed in this section; however, most microorganisms that cause disease in the neonate may produce cutaneous infections, and those infections are discussed in other chapters when relevant. For additional information on bacterial infections of the skin, the reader is referred to the text by Solomon and Esterly [562] and the reviews by Swartz and Weinberg [563] and Frieden [568]. Excellent color photographs are included in the Color Atlas of Pediatric Dermatology by Weinberg and coworkers [569].…”

“…After the staphylococcal pandemic of the 1950s, information on the colonization of the skin, predisposing factors responsible for neonatal skin infection, bacterial transmission in the nursery, the inflammatory response of the skin to bacterial invasion, virulence factors of staphylococci, and methods of prevention of cross-infection became available. These studies are described in part in Chapters 14 and 35 and have been reviewed elsewhere [568,569].…”