Blink reflex, H-reflex and nerve-conduction alterations in leprosy patients

Mora-Brambila, Ana Bertha; Trujillo-Hernández, Benjamı́n; Coll-Cardenas, Rafael; Huerta, Miguel; Trujillo, Xóchitl; Vásquez, Clemente; Olmedo-Buenrostro, Bertha Alicia; Millán‐Guerrero, Rebeca O.; Elizalde, Alejandro

doi:10.47276/lr.77.2.114

Cited by 11 publications

(4 citation statements)

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“…In those with subclinical involvement, the most common abnormal parameter was prolonged R1 in 8 (67%), followed by R2c in 5 (42%) and R2i in 3 (25%) similar to a previous study, 14 whereas few studies have shown a higher incidence of abnormal R2c (30-80%). 23,24 F-wave studies are particularly useful in detecting conduction problems in the proximal regions of the nerves and in the evaluation of axonal as well as demyelinating polyneuropathies and radiculopathies. 40 In our study, 7/42 (17%) had prolonged F-wave latency.…”

Section: Discussionmentioning

confidence: 99%

“…The blink reflex evaluates the integrity of trigeminal and facial nerves, which form the afferent and efferent limbs of the reflex, respectively. 23 It has two components, namely the R1 wave (ipsilateral) and the R2 wave (bilateral). Studies done in patients in the LL spectrum have shown abnormal blink reflex ranging from 30-80%.…”

Section: Introductionmentioning

confidence: 99%

“…Studies done in patients in the LL spectrum have shown abnormal blink reflex ranging from 30-80%. 23,24 To address these lacunae, this study examines the prevalence and pattern of clinical and electrophysiological changes in the facial nerve trunk and its branches, namely temporal, zygomatic, and marginal mandibular, including F wave and blink reflex, in patients with active disease, and correlates the findings with the clinical presentation.…”

Section: Introductionmentioning

confidence: 99%

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Facial nerve and branch dysfunction in leprosy - a study from India

Philip

George

Mathew

et al. 2022

LEPROSY

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Objective Involvement of the facial nerve in leprosy can result in debilitating features, including blindness. Electrophysiological studies addressing abnormalities in the facial nerve along with its branches are limited. This study was designed to assess the prevalence and pattern of clinical and subclinical involvement of the facial nerve and its branches in patients with active disease. Methods A hospital-based cross-sectional study was done in 75 patients who had leprosy. The facial nerve and branches were examined clinically and assessed electro-physiologically with nerve conduction studies (NCS), F wave, blink reflex and synkinesis. Results 64/75 (85%) patients had facial nerve involvement, of whom 58 had subclinical involvement. detected by electrophysiology and 6 had facial nerve palsy. 83% of patients had subclinical involvement and belonged to the borderline spectrum (27-BL, 21-BT), and 23 (48%) were in reactional states (T2R-12, T1R-11). Patients with facial lesions and reactional states showed significant association (p = 0.035) with clinical or subclinical facial nerve involvement. The marginal mandibular branch was the most commonly affected (50%) in those with subclinical involvement while in those with facial nerve palsy, the facial nerve trunk was most affected (50%). 12/58 (21%) with subclinical involvement and 5/6 patients with facial nerve palsy had an abnormal blink reflex. Abnormal F wave was observed in 7/42 (17%), (4 subclinical/3 facial nerve palsy). Conclusion Electrophysiological changes in the facial nerve, without clinical signs are common among patients in the borderline spectrum with about half being in reactional states. We know that many institutions may not have the equipment to conduct nerve

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Facial nerve and branch dysfunction in leprosy - a study from India

Philip

George

Mathew

et al. 2022

LEPROSY

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“…Unfortunately, the latencies of the blink reflex R1 and R2 components are not provided. Since the R1 latency can yield information on trigeminal conduction (5), and the R2 latency on synaptic transmission and interneuron excitability (6, 7), the lack of such data is a serious limitation of this paper.…”

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confidence: 99%