Blindness from quinine toxicity.

Bacon, Pamela; Spalton, David J.; Smith, S. E.

doi:10.1136/bjo.72.3.219

Cited by 64 publications

(42 citation statements)

References 15 publications

(1 reference statement)

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“…[12][13][14][15] Elapsed time from most recently administered quinine infusion (QET) was measured. A significant positive association was found between QET and both maximal-response a wave amplitude (P ¼ 0.03) and cone a wave amplitude (P ¼ 0.04).…”

Section: Discussionmentioning

confidence: 99%

The effects of hypoxia on the ERG in paediatric cerebral malaria

Lochhead

Movaffaghy

Falsini

et al. 2009

Eye

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Background/aims Cerebral malaria (CM) is a disease of high mortality worldwide. It can be associated with malarial retinopathy (MR) resulting from impaired perfusion within the retinal microvasculature. Areas of capillary nonperfusion (CNP) appear white (retinal whitening) on ophthalmoloscopy. In this study, electrophysiological investigations were performed to investigate the physiological consequences of these hypoxic and ischaemic changes. Methods Children admitted with CM were assessed for inclusion in the study. Those with MR underwent further detailed fundus assessment to quantify retinal whitening and were then designated a severity score. Electrophysiological recordings were performed using a miniganzfeldt stimulator with calibration to the International Society for Clinical Electrophysiology of Visual (ISCEV) standards. ERG data were then analysed with respect to presence of MR and also graded disease severity. Results Thirty-one children were recruited with a diagnosis of CM, 20 had MR (group 1), and 11 had absent MR (group 2). Statistical analyses of these two groups showed a significant relationship between reduced single flash cone b wave amplitude (CBWA) and increased severity of retinal whitening/ CNP (Po0.05). Cone and maximal response b : a wave ratios remained 41 in all subjects. Conclusion Retinal whitening/CNP in MR is associated with significant changes in ERG cone b wave function. The relatively high b : a ratio is compatible with the high frequency of MR resolution without sequelae.

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Section: Discussionmentioning

confidence: 99%

The effects of hypoxia on the ERG in paediatric cerebral malaria

Lochhead

Movaffaghy

Falsini

et al. 2009

Eye

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“…Typical disorders with a negative ERG are X-linked congenital retinoschisis (XRS) [12,20], congenital stationary night blindness (CSNB) [19], ischemic retinopathy caused by central retinal artery or vein occlusion [10,18], melanoma-associated retinopathy (MAR) [2,11], and toxic retinopathies caused by drugs (e.g. vigabatrin, quinine) [1] or intraocular metallic foreign bodies resulting in ocular siderosis [22]. In addition, negative ERGs were also reported in few cases of retinitis pigmentosa [3] and cone (-rod) dystrophy [5,13] and in further rare disorders (for a detailed list of disorders with negative ERGs and their references, see Koh et al 2001) [15].…”

Section: Introductionmentioning

confidence: 99%

Dysfunction of transmission in the inner retina: incidence and clinical causes of negative electroretinogram

Renner

Kellner

Cropp

et al. 2006

Graefe's Arch Clin Exp Ophthalmo

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The incidence of a negative ERG can differ between the laboratories depending on the causes for ERG recording and was in our laboratory 2.9% in a consecutive series of patients with inherited or acquired retinal degenerations. A disorder characteristically associated with negative ERG (e.g. XRS, CSNB, MAR) was diagnosed in 53% of these patients, whereas in 47% the negative ERG indicated an unexpected post-receptoral dysfunction, e.g. in cone (-rod) dystrophy or RP. The ON-bipolar pathway was affected in most cases.

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“…Elle est pratiquement toujours associée à un champ visuel rétréci avec isoptères concentriques [Smilkstein, et al, 1987], [Hall et al, 1997], [Bacon et al, 1988]. A plus long terme, on observe au fond d'oeil des vaisseaux rétrécis et une papille pâle [Brinton et al, 1980], [Tormene, Riva C., 2007].…”

Section: Cliniqueunclassified

“…Il pourrait s'agir d'une part, d'une toxicité directe de la quinine sur les cellules rétiniennes qui interfèrerait avec la neurotransmission cholinergique (et donc atteinte des cellules ganglionnaires cholinergiques…) [Canning, Hague, 1988] conduisant à la perte visuelle aigüe et d'autre part, d'une ischémie rétinienne conduisant à un rétrécissement des artérioles et une pâleur papillaire [Bacon, et al, 1988], [Zahn et al, 1981], [Hall, et al, 1997].…”

Section: Mécanismes De Toxicitéunclassified

Vi-2 : Apport De l'ÉLECTROPHYSIOLOGIE Chez l'ADULTE : Exemples

Rigaudière¹,

Gargasson²

2012

Oeil Et Physiologie De La Vision

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Blindness from quinine toxicity.

Cited by 64 publications

References 15 publications

The effects of hypoxia on the ERG in paediatric cerebral malaria

The effects of hypoxia on the ERG in paediatric cerebral malaria

Dysfunction of transmission in the inner retina: incidence and clinical causes of negative electroretinogram

Vi-2 : Apport De l'ÉLECTROPHYSIOLOGIE Chez l'ADULTE : Exemples

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