Blindness: A Sequela of Sinonasal Small Cell Neuroendocrine Carcinoma

Avitia, Sofia; Osborne, Ryan F.

doi:10.1177/014556130408300810

Cited by 9 publications

(9 citation statements)

References 7 publications

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“…As in our systematic review and in the literature, there is variability in treatment modality. Surgery, radiation, chemotherapy, or a combination have all been reported . No established algorithm yet exists for the treatment of sinonasal SCNEC.…”

Section: Discussionmentioning

confidence: 99%

“…Over the years, SCNEC has been identified by many names including oat cell carcinoma, small cell undifferentiated carcinoma, small cell tumor, neuroendocrine carcinoma, small cell neuroendocrine carcinoma and others . The abbreviations used to identify it are equally numerous—SCNEC, SNEC, SCUC, SCC, SCNC, NEC, and others . This varied nomenclature makes review of the literature of this tumor particularly challenging.…”

mentioning

confidence: 99%

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Sinonasal small cell neuroendocrine carcinoma: a systematic review of 80 patients

Rivero

Liang

2016

Int Forum Allergy Rhinol

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Sinonasal small cell neuroendocrine carcinoma: a systematic review of 80 patients

Rivero

Liang

2016

Int Forum Allergy Rhinol

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“…This is similar to experience reported earlier. 3 SmCC has also been reported to be associated with multiple endocrine neoplasia, 4 though this was not our experience. SmCC has a morphologic, immunohistochemical and ultrastructural appearance similar to that of its pulmonary homolog.…”

Section: Discussionmentioning

confidence: 56%

Primary Small Cell Carcinoma of Nasal Cavity Presenting as Unilateral Blindness

Chauhan¹,

Chakarborty²,

Nath³

et al. 2011

International Journal of Head and Neck Surgery

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Primary sinonasal small cell carcinomas are extremely rare lesions. We present a case of 29-year-old male patient, who initially presented with recurrent right sided nasal obstruction and occasional epistaxis, but came to medical attention when he developed progressive deterioration of vision in ipsilateral eye. Radiological examination showed a tumor with epicenter in right nasal cavity with extensive local infiltration. The histopathology picture and immunohistochemistry profile of the tumor showed it to be a primary small cell neuroendocrine tumor. Extensive imaging studies revealed no other site of primary. He was treated with induction chemotherapy followed by concomitant chemoradiotherapy. Complete clinical response was seen and the patient has been disease free since last 20 months. The report discusses the diagnostic criteria which differentiates this extremely rare but aggressive tumor from a much more common and more indolent tumor, esthesioneuroblastoma.

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“…10 Head and neck SCC and SNEC carry a poor prognosis secondary to a high rate of metastasis. 2,10,12,13 …”

Section: Discussionmentioning

confidence: 99%

Colliding Tumor of the Paranasal Sinus

Barham

Said

Ramakrishnan

2013

Allergy�Rhinol (Providence)

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Sinonasal malignant neoplasms comprise only 3% of all head and neck malignancies. Synchronous and metachronous tumors of the head and neck have been described, but rarely have there been reports of a single tumor with two distinct histologies. Here, we describe a case of a sinonasal malignant neoplasm with two distinct histologies. A case report and literature review was performed. We present a case of paranasal sinus neoplasm involving two malignant cell types. An 83-year-old woman presented with a 2-year history of symptoms suggestive of chronic sinusitis, which included nasal congestion and intermittent midface pressure. More recently, her symptoms progressed with the development of left-side epistaxis and she was found to have a mass in the left maxillary and ethmoid regions. A biopsy of the maxillary sinus mass revealed a moderately differentiated squamous cell carcinoma (SCC). She underwent complete resection of the lesion through an extended endoscopic approach. Final pathological analysis showed a malignant neoplasm with two distinct malignant morphologies; a moderately differentiated SCC and small cell neuroendocrine carcinoma. Appropriate diagnosis and treatment of head and neck malignancy depends on accurate tumor classification and staging. We present a case of a sinonasal tumor with two distinct malignant entities and review the available literature on the subject. Additionally, we discuss the etiologic theories and challenges in planning the optimal approach to management in this scenario.

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Blindness: A Sequela of Sinonasal Small Cell Neuroendocrine Carcinoma

Abstract: Figure J. A: Coronal MRJ shows the tumor extension into the right fro ntoethmoid region. B: Axial MRJ shows the tumor extension into the sphenoid sinus and its encroachment on the right orbital apex.

Cited by 9 publications

References 7 publications

Sinonasal small cell neuroendocrine carcinoma: a systematic review of 80 patients

Sinonasal small cell neuroendocrine carcinoma: a systematic review of 80 patients

Primary Small Cell Carcinoma of Nasal Cavity Presenting as Unilateral Blindness

Colliding Tumor of the Paranasal Sinus

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