Blinded, Randomized, Multicenter Study to Evaluate Single Administration Pegfilgrastim Once per Cycle Versus Daily Filgrastim as an Adjunct to Chemotherapy in Patients With High-Risk Stage II or Stage III/IV Breast Cancer

Abstract

A single injection of pegfilgrastim 100 microg/kg per cycle was as safe and effective as daily injections of filgrastim 5 microg/kg/d in reducing neutropenia and its complications in patients who received four cycles of doxorubicin 60 mg/m(2) and docetaxel 75 mg/m(2).

Single-dose pegfilgrastim is comparable to daily filgrastim in mobilizing peripheral blood stem cells: a case-matched study in patients with lymphoproliferative malignancies

“…In another study, in the allogeneic setting, PEGFIL at a dose of 12 mg was successfully used to mobilize and collect blood stem cells from 25 healthy family and unrelated donors [16]. In patients with chemotherapy-induced neutropenia, however, a single PEGFIL dose of 6 mg once per cycle has been shown to be as effective as multiple daily doses of FIL 5 μg/kg [8,17]. Similarly, when used after high-dose chemotherapy and ASCT, a single 6-mg dose of PEGFIL given up to 5 days after autografting has been shown to be at least as effective as daily FIL for promoting engraftment [18,19].…”

A phase 2 pilot study of pegfilgrastim and filgrastim for mobilizing peripheral blood progenitor cells in patients with non-Hodgkin's lymphoma receiving chemotherapy

“…In patients receiving myelosuppressive chemotherapy, a convenient, single, fixed dose of pegfilgrastim provides neutrophil support comparable to that provided by multiple daily injections of filgrastim. 6,7 Furthermore, limited data from previous studies suggest that a single dose of pegfilgrastim 6 or 12 mg can mobilize a sufficient number of peripheral blood progenitor cells to support early engraftment and sustained hematologic reconstitution when transplanted following highdose chemotherapy. 8,9 There is also some evidence that a single dose of pegfilgrastim 12 mg can effectively mobilize peripheral blood progenitor cells in related and unrelated donors for allogeneic transplantation.…”

Synthesis and antimicrobial activity of ciprofloxacin and norfloxacin permanently bonded to polyethylene glycol by a thiourea linker

“…Norfloxacin was also attached to methacrylate polymers. 14 The goal of this work was to investigate the antimicrobial effect of the quinolonecarboxylic acid dimers prepared with a PEG linker, and to study the effect of PEGylation on the antibacterial activity.To investigate the separate effect of the PEGylation and dimerization of 1 and 2 on the antimicrobial effect, both the mono-and bifunctional PEG derivatives of the antimicrobial agents were prepared.Monomethoxy-PEG (MW average ¼1132 Da) and PEG (MW average ¼ 1382 Da) were converted 15 into the monoamino (3) and diamino (4) derivatives, whose treatment with thiophosgene gave the corresponding mono-and diisothiocyanates 5 and 6, respectively (Scheme 1).The reaction of 4 and 6 with ciprofloxacin and norfloxacin under mild conditions (Scheme 1) led to the PEG-conjugates (7,8,9,10), whose structures were proved by matrix-assisted laser desorption/ ionization (MALDI) mass spectrometry and NMR spectroscopy. (Figure 1 represents the MALDI-time of flight (TOF) mass spectrum of 6 and 9).…”

“…Monomethoxy-PEG (MW average ¼1132 Da) and PEG (MW average ¼ 1382 Da) were converted 15 into the monoamino (3) and diamino (4) derivatives, whose treatment with thiophosgene gave the corresponding mono-and diisothiocyanates 5 and 6, respectively (Scheme 1).The reaction of 4 and 6 with ciprofloxacin and norfloxacin under mild conditions (Scheme 1) led to the PEG-conjugates (7,8,9,10), whose structures were proved by matrix-assisted laser desorption/ ionization (MALDI) mass spectrometry and NMR spectroscopy. (Figure 1 represents the MALDI-time of flight (TOF) mass spectrum of 6 and 9).…”