Blepharochalasis: something to cry about

Browning, Richard; Sanchez, April T.; Mullins, Stephen; Sheehan, Daniel J.; Davis, Loretta S.

doi:10.1111/cup.12841

Cited by 9 publications

(8 citation statements)

References 16 publications

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“…Although blepharochalasis associated with systemic symptoms has been previously reported, the cause remains unclear [1]. However, immunofluorescence studies have detected IgA antibodies on elastic fibers in blepharochalasis patients [3,4,9,10], suggesting an immunologic basis. In our patient, perivascular IgA deposits were detected in the dermis.…”

Section: Discussionmentioning

confidence: 97%

Stepwise surgery with variable adjustments for severe blepharochalasis with multiple chemical sensitivity: a case report

Nagano

Domoto

Azuma

et al. 2020

Case Reports in Plastic Surgery and Hand Surgery

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Section: Discussionmentioning

confidence: 97%

Stepwise surgery with variable adjustments for severe blepharochalasis with multiple chemical sensitivity: a case report

Nagano

Domoto

Azuma

et al. 2020

Case Reports in Plastic Surgery and Hand Surgery

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“…Even though there was limited available data in relevant reports for us to compare, a published review had summarized the postoperative results [ 5 ]. The review stated that surgery in blepharochalasis patients was complicated by a high incidence of overcorrection.…”

Section: Discussionmentioning

confidence: 99%

“…Although the disorder has been clinically known for over 200 years, the pathogenesis remains unknown [ 2 ]. Till date, there is no large cohort study that dealt with blepharochalasis, and most of the publications were case reports or small series [ 3 – 5 ], as the epidemiological data of blepharochalasis is unavailable. In 2009, Koursh et al [ 6 ] summarized 67 cases of blepharochalasis from 1977 to 2006, describing the natural history, epidemiology, clinical features, etiology, histopathology and pathogenesis, differential diagnosis, treatment and also the prognosis in detailed.…”

Section: Introductionmentioning

confidence: 99%

Blepharochalasis: clinical and epidemiological characteristics, surgical strategy and prognosis-- a retrospective cohort study with 93 cases

Zhou

Ding

2021

BMC Ophthalmol

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Background Blepharochalasis is a rare eyelid disorder but eventually leading to destructive eyelid deformation. Until now the clinical and epidemiological data are unavailable. This study aimed to report the manifestations, epidemiological characteristics and surgical strategy of a large series of blepharochalasis patients with long-term follow-up. The prognosis of different clinical deformities was also investigated. Methods This was a retrospective cohort study, including consecutive patients diagnosed with blepharochalasis in a single center. Blepharoplasty and other surgical approaches were performed according to manifestations, after a 2-year quiescent period with no recurrent attacks and exacerbation of lesions. Prognosis after surgery was recorded. Results A total of 93 patients, with a mean age of 30.77 ± 14.04 (range: 9.00–70.00) years were included. Of all those 93 patients, 72.04% were females (67, P = 0.02). The mean follow-up was 5.29 ± 2.07 (range: 3–10) years before surgery, and 2.07 (range:1.54–4.22)years follow-up after surgery. The mean age of onset of blepharochalasis symptoms was 10.09 ± 3.32 (range: 5–16) years, and 83.87% patients got symptoms in puberty. With an average of 5 times per year, the mean duration of each acute attack was 28.12 ± 1.01 (rang: 2–192) hours. The mean duration from the onset of acute attack to the quiescent stage lasted for 7.33 ± 2.05 (range: 4–10) years. Most of the cases (88, 94.62%) had more than one manifestation at the end of the last follow-up before surgery. Ptosis (48.39%) was the most common deformity. Followed by lacrimal gland prolapse (44.09%), canthal angle deformity (29.04%), lower eyelid retraction (17.20%). After surgery, the functional and cosmetically acceptable results were achieved in all patients except for overcorrection in 5 (11.90%) patients with ptosis. The lacrimal gland prolapse recurred in two (4.00%) patients at 29 and 36 months after surgery. Conclusions Blepharochalasis is rare but mostly occurred in adolescent females. The process from the onset to the stable stage usually lasted for about 7 years, which might be associated with the onset of puberty. Surgical management of clinical manifestations after at least 2-year follow-up period of quiescence would be appropriate in order to observe a great plastic effect, low overcorrection and recurrence rate.

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“…Image tests are unnecessary, as they do not demonstrate anomalous results, and palpebral biopsy does not demonstrate specific results, frequently showing elastic fibers decrease as the episodes progress [1,2]. Regarding pharmacological treatment, there is poor response to oral or local antihistamines and cortisone [5]. Once ptosis and dermatochalasis appear the only effective treatment is surgery.…”

Section: Introductionmentioning

confidence: 99%