Bleomycin sulfate in the treatment of mosaic plantar verrucae: A follow-up study

Sollitto, Ronald J.; Pizzano, David M.

doi:10.1016/s1067-2516(96)80036-6

Cited by 17 publications

(18 citation statements)

References 4 publications

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“…178 The success of bleomycin treatment can be technique-dependent. 179 Using a bifurcated needle has been reported to improve outcome. 180,181 One study achieved a 92% cure rate of 258 warts with only one treatment of bleomycin using a technique of multiple wart punctures with a bifurcated needle.…”

Section: Antimitotic Therapymentioning

confidence: 99%

An Armamentarium of Wart Treatments

Lipke¹

2006

Clinical Medicine & Research

282

295

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Patients and clinicians experience the frustration of cutaneous viral warts caused by infection with the human papilloma virus (HPV).Warts appear in various forms on different sites of the body and include common warts (verruca vulgaris), plane or flat warts, myrmecia, plantar warts, coalesced mosaic warts, filiform warts, periungual warts, anogenital warts (venereal or condyloma acuminata), oral warts and respiratory papillomas. Cervical infection with HPV is now known to cause cervical cancer if untreated. A review of the medical literature reveals a huge armamentarium of wart monotherapies and combination therapies. Official evidence-based guidelines exist for the treatment of warts, but very few of the reported treatments have been tested by rigorous blinded, randomized controlled trials.Therefore, official recommendations do not often include treatments with reportedly high success rates, but they should not be ignored when considering treatment options. It is the purpose of this review to provide a comprehensive overview of the wart treatment literature to expand awareness of the options available to practitioners faced with patients presenting with problematic warts. Warts of the genital tract carry a much more ominous and pernicious threat for women in particular. It has been estimated that up to 70% of sexually active women become infected during their lifetime with human papillomavirus (HPV), the infective agent that causes warts. 3-5 A causal role for HPV infections in cervical cancer has been documented beyond reasonable doubt. HPV DNA is present in virtually all cervical cancer cases worldwide, with it being detected in 99.7% of an international series of cervical cancers by genetic amplification techniques and in 100% of cases as confirmed by histological review. 6,7 Cervical cancer is the most frequent common cancer in developing countries and the second most common cancer in women worldwide. 3 The association between HPV infection and cervical cancer is so strong that HPV is now considered the first positive cause of any human cancer ever identified. 3This raises the level of concerns over HPV prevention, screening and treatment from that of a nuisance condition to that of a major public health concern. Attention is beginning to focus on the viral factors that determine persistence and neoplastic progression to cancer and the possible role of HPV in other nongenital cancers (e.g., skin, upper aerodigestive tract). [8][9][10][11][12][13][14][15][16][17] Patients with warts seek advice from general practitioners, pharmacists, naturopaths, allied health professionals, family or friends, dermatologists, gynecologists, obstetricians and pediatricians for treatment and may present with recalcitrant warts that have been previously treated with anything from folk remedies to hypnosis to over-the-counter medications to more aggressive clinic-based treatments. Unfortunately, even with years of medical literature on this subject, high-quality, level I evidence for the efficacy of almost all treatments is no...

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Section: Antimitotic Therapymentioning

confidence: 99%

An Armamentarium of Wart Treatments

Lipke¹

2006

Clinical Medicine & Research

282

295

View full text Add to dashboard Cite

show abstract

“…Intralesional injection of bleomycin was reported effective in the treatment of recalcitrant warts for the first time in 1976 1,2 . Bleomycin sulphate is a mixture of cytotoxic glycopeptide antibiotics isolated from a strain of Streptomyces verticillus 3 . It appears that bleomycin has antitumour, antibacterial and antiviral properties, and is therefore particularly valuable when the immune response is diminished or absent 4 .…”

Section: To the Editormentioning

confidence: 99%

“…It appears that bleomycin has antitumour, antibacterial and antiviral properties, and is therefore particularly valuable when the immune response is diminished or absent 4 . The mode of action seems to be primarily mediated by inhibition of DNA synthesis and degradation of preformed DNA 3,5 …”

Section: To the Editormentioning

confidence: 99%

“…The bleomycin injections are recommended intralesionally at a concentration of 1 U/mL, diluted in sterile water 6 . Care should be taken not to penetrate intradermally, and to ensure complete exposure of all the verrucous tissue to the medication 3,6 …”

Section: To the Editormentioning

confidence: 99%

“…Bleomycin intralesional injections are considered to be one of the most successful methods of treating common and plantar warts in patients infected with human immunodeficiency virus 3–6 . There are no reports of their use in genital or oral mucosa condylomas 2,5 .…”

Section: To the Editormentioning

confidence: 99%

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