Bleomycin-Induced Fulminant Hyperpyrexia: A Report of Two Cases and Review of Literature

Abstract

Bleomycin is a commonly used cytotoxic agent that has proven its efficacy over the years. Though a common part of many protocols targeting lymphomas and germ cell tumors, it does have some serious adverse effects. Bleomycin is notorious for pulmonary toxicity and very rarely may cause fulminant hyperpyrexia. We describe two cases of classical Hodgkin's lymphoma (cHL) developing acute fulminant hyperpyrexia after administration of the first dose of bleomycin as part of chemotherapy protocol. This is a rare adverse reaction that closely mimics anaphylaxis and has an unpredictable and possibly fatal course. Health care professionals involved in the administration of chemotherapy need to be very vigilant in monitoring for symptoms of this reaction.

Pharmacogenetics of anticancer antibiotics

“…Известно, что побочные эффекты при его применении характеризуются широкой межиндивидуальной вариабельностью [37]. Токсическое действие блеомицина на легкие является одной из причин, лимитирующих дозировку препарата [38].…”