Bleomycin-induced cutaneous toxicity in the rat: analysis of histopathology and ultrastructure compared with progressive systemic sclerosis (scleroderma

Mountz, John D.; Minor, M.B.Downs; Turner, Robert A.; Thomas, Michael C.; Richards, Frederick; Pisko, Edward J.

doi:10.1111/j.1365-2133.1983.tb01080.x

Cited by 61 publications

(23 citation statements)

References 22 publications

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“…Schleimhaut v.a. Hyperpigmentierungen, Hyperkeratosen, Exantheme, Alopezien, Ulzerationen oder Stromatitiden; selten infiltrierte Plaques oder Knoten bis hin zu sklerodermiformen Indurationen der Haut [1,2,5,11,16,19], wobei die mittlere hauttoxische Dosis in Studien mit vergleichsweise großen Patientenkollektiven mit etwa 165 mg angegeben wird [10,18].…”

Section: Bleomycin-induzierte Pssartige Pseudosklerodermieunclassified

“…die Haut und die Lunge [19], da diese Organe das Zytostatikum selektiv anreichern bzw. vermindert metabolisieren.…”

Section: Bleomycin-induzierte Pssartige Pseudosklerodermieunclassified

“…Die vaskuläre Phase wird gefolgt von einer zellulären, in der es zu Fibroblastenaktivierung nahe des geschä-digten Gefäßes mit nachfolgender Fibrosierung des Gewebes kommt, wobei die Fibroblastenaktivierung über diverse, von Endothelzellen freigesetzte Zytokine, beispielsweise TGF-beta, abläuft. Tierexperimentelle Studien haben diesen Pathomechanismus bestätigt und konnten nahezu ein Fehlen entzün-dungszellvermittelter Immunreaktionen nachweisen [19]. So produzieren Fibroblasten aus dem fibrosierenden Gewebe auch in vitro übermäßig Typ-I und III-Kollagen [14].…”

Section: Besprechungunclassified

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Bleomycin-induzierte PSS- artige Pseudosklerodermie

Behrens

Reuther

et al. 1998

Der Hautarzt

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Although the association between administration of the antitumor agent bleomycin and the development of cutaneous fibrosis is established, there are only a small number of cases of bleomycin-induced scleroderma described in the literature. We report the development of generalised scleroderma with wide spread hyperpigmentation in a 52-year-old male patient, who received a total dose of 360 mg bleomycin in combination with cisplatin and etoposid for therapy of a malignant testicular seminoma. The clinical cutaneous alterations as well as the histological findings were indistinguishable from those encountered in progressive systemic sclerosis (PSS). In contrast to PSS however, Raynaud's phenomenon, cutaneous calcinosis, teleangiectasia, arthritis and involvement of additional organs were all absent. PSS-typical auto-antibodies were negative. Even 18 months after discontinuation of the drug and treatment with UVA1 phototherapy (3-4 times per week with 20 J/cm2) as well as physiotherapy, the skin changes had still not resolved. Based on our case and a detailed review of the literature, we discuss characteristics of bleomycin-induced scleroderma including pathogenesis, treatment modalities and course.

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Section: Bleomycin-induzierte Pssartige Pseudosklerodermieunclassified

“…die Haut und die Lunge [19], da diese Organe das Zytostatikum selektiv anreichern bzw. vermindert metabolisieren.…”

Section: Bleomycin-induzierte Pssartige Pseudosklerodermieunclassified

Section: Besprechungunclassified

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Bleomycin-induzierte PSS- artige Pseudosklerodermie

Behrens

Reuther

et al. 1998

Der Hautarzt

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“…One of the better-known models is bleomycin-induced scleroderma. A repeated intradermal or subcutaneous injection of bleomycin into rats and mice leads to the development of dermal sclerosis (Mountz et al, 1983;Yamamoto;Yamamoto & Nishioka, 2001Yamamoto, Takahashi, Takagawa, Katayama, & Nishioka, 1999). The latter is microscopically characterized by the deposition of thick collagen bundles, homogeneous acellular material, and cellular infiltrates of T-cells, macrophages, and mast cells.…”

Section: Pathophysiologymentioning

confidence: 99%

Scleroderma Renal Crisis

Chabtini¹,

Mounayar²,

Azzi³

et al. 2012

Systemic Sclerosis - An Update on the Aberrant Immune System and Clinical Features

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“…Among other toxicities in humans, cutaneous toxicity including hyperpigmentation, alopecia, sclerosis, gangrene, edema, and fibrosis has been reported at higher incidence (14). BLM has been reported to be concentrated in the lung and skin due to the lower activity of the BLM-inactivating enzyme in these tissues (15,28 (Table II).…”

Section: Introductionmentioning

confidence: 99%

Bleomycin-Induced Arthritis and Dermatitis in Rats

Kato

Takada

Ishii³

1997

Toxicol Pathol

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We investigated the effect of the antitumor drug bleomycin (BLM) on synovial membrane and periarticular deep dermis in 10-wkold young adult rats. BLM was found to induce edema, mononuclear cell infiltration and necrosis of the synovial membrane in the knee and tarsal joint, and inflammation in the deep dermis of the plantar hindfoot and digital pulvini in these rats after subcutaneous administration of 20 mg/kg for 3 days. After a 4-wk recovery period, foci of degenerative collagen bundles were observed in the deep dermis of the plantar hindfoot in spite of complete recovery of the lesions in the other dermal and synovial membrane sites. The synovitis was determined to begin with vesiculation of the macrophage-type lining cells, followed by edema and cell infiltration, especially near ligament insertion sites in the knee joint. The early dermal lesion consisted of dissociation of endothelial and subendothelial cells in small blood vessels thought to be postcapillary venules, edema, and monocyte infiltration. The severity of arthritis was greater in young adults than juvenile rats. From these results, BLM was shown to have a toxic effect on synovial lining cells and to induce inflammation in the synovial membrane and periarticular dermis.

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Bleomycin-induced cutaneous toxicity in the rat: analysis of histopathology and ultrastructure compared with progressive systemic sclerosis (scleroderma

Cited by 61 publications

References 22 publications

Bleomycin-induzierte PSS- artige Pseudosklerodermie

Bleomycin-induzierte PSS- artige Pseudosklerodermie

Scleroderma Renal Crisis

Bleomycin-Induced Arthritis and Dermatitis in Rats

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