Blending and cavern formation within non-Newtonian fluids in stirred tanks: Application to nuclear waste fluid processing

Noble, Sean M.; Thomas, John A.

doi:10.1016/j.ces.2022.118184

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“…Each predicted blend time was within 25% of the measured value. This agreement, which is consistent with a previous report, suggests that advection and diffusion are properly modeled (Noble et al, 2023).…”

Section: Methodssupporting

confidence: 93%

CFD‐based bioreactor model with proportional–integral–derivative controller functionality for dissolved oxygen and pH

Oliveira,

Pace,

Thomas

et al. 2023

Biotech & Bioengineering

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A physics‐based model for predicting cell culture fluid properties inside a stirred tank bioreactor with embedded PID controller logic is presented. The model evokes a time‐accurate solution to the fluid velocity field and overall volumetric mass transfer coefficient, as well as the ongoing effects of interfacial mass transfer, species mixing, and aqueous chemical reactions. The modeled system also includes a direct coupling between process variables and system control variables via embedded controller logic. Satisfactory agreement is realized between the model prediction and measured bioreactor data in terms of the steady‐state operating conditions and the response to setpoint changes. Simulation runtimes are suitable for industrial research and design timescales.

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Section: Methodssupporting

confidence: 93%