Bleeding Time Tables

Rodgers, R.P. Channing

doi:10.1055/s-2007-1002659

Cited by 17 publications

(3 citation statements)

References 13 publications

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“…7,8 Adhesion and activation parameters can be extrapolated from the analysis of relevant plasma proteins, surface marker expression, granular content and release, and signaling pathways. 7,8 However, the only truly functional platelet tests used to date, such as the bleeding time (which is losing popularity) [9][10][11] and light transmission aggregometry (LTA), have major methodological limitations. 8,[12][13][14][15][16][17][18][19] LTA relies on the measurement of light transmission through a cuvette filled with platelet-rich plasma (PRP) placed between a light source and a photocell.…”

Section: Introductionmentioning

confidence: 99%

A novel flow cytometry–based platelet aggregation assay

Cuyper

Meinders

Vijver

et al. 2013

Blood

132

148

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Section: Introductionmentioning

confidence: 99%

A novel flow cytometry–based platelet aggregation assay

Cuyper

Meinders

Vijver

et al. 2013

Blood

132

148

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show abstract

“…catecholamines), influenced by vascular disorders, lacks specificity and sensitivity, and is not predictive of bleeding. 31 The bleeding time increases unspecifically during surgery and transfusion, 32 and does not allow the differentiation between bleeding and non-bleeding patients. 33 Platelet count, routine coagulation tests (aPTT, PT), and thrombelastometry/-graphy 34 do not permit diagnosis of platelet disorder.…”

Section: Not Recommended For Platelet Function Testingmentioning

confidence: 99%

Peri-operative diagnosis and treatment of platelet disorders

Kozek-Langenecker¹

2010

Southern African Journal of Anaesthesia and Analgesia

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“…The ACT does use whole blood but the test ends with initial fibrin formation, so limited information can be gathered about platelet function. The bleeding time does take into account the function of platelets, but it has been suggested that since this test looks at a standardized cut in the skin, it is not useful in predicting bleeding from surgical intervention in other areas of the body (4,5).…”

Section: Introductionmentioning

confidence: 99%

Surface Activation of Whole Blood: Clot Detection with a Thrombelastograph

Stover,

Stammers

1995

J Extra Corpor Technol

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Various methods are used to decrease the length of time required to generate useful data from thrombelastography (TEG). The quicker this data can be produced and analyzed the sooner decisions can be made for hemostasis management. The present study was designed to determine the effects of glass compared to plastic with respect to their effect on the activation of the intrinsic pathway of coagulation. Thirty-seven samples of native whole blood (NWB) were drawn via radial artery catheter, internal jugular sheath or by direct venous puncture. Half of each sample was placed in a glass test tube and the other half in a plastic (polypropylene) container, and allowed to sit for periods of 1 minute (n = 4 ), 1.5 minutes (n = 5), 2 minutes (n = 9), 2.5 minutes (n = 9) and 3 minutes (n = 10). The glass activated samples were placed in plastic TEG cups that had been randomized to one of the two TEG channels, with the plastic activated samples being placed in metal TEG cups in the opposite channel. This resulted in a total of seventy-four TEG profiles. There were no significant correlations (p < 0.05) between any of the inter- or intra-related TEG parameters, reaction time (R time), kinetic time (K time), maximum amplitude (MA), or alpha angle (AA). However, the R time of the glass activated samples showed a linear decrease in time required to achieve this value. The plastic activated samples did not exhibit this linear decrease in R time. The thrombelastograph index (TI) showed an initial hypocoagulability at 1 min for glass (-1.84 ± 3.46) when compared to plastic ( + 1.58 ± 0.23). At 1.5 minutes, the TI for glass ( -0.12 ± 2.97) approached those for plastic ( +0.035 ± 1.68) and remained relatively close until3 min of activation when the glass samples TI (2.48 ± 3.16) proved to be hypercoagulable when compared to the plastic at 3 min, TI (1.97 ± 2.64). The MA, K time and alpha angle seemed to be largely unaffected by the different activation times. This study has shown that glass activation may be used effectively to decrease the time required to generate TEG data from NWB samples, and that the glass activation does not seem to affect the TEG parameters significantly other than the R time.

show abstract

Bleeding Time Tables

Cited by 17 publications

References 13 publications

A novel flow cytometry–based platelet aggregation assay

A novel flow cytometry–based platelet aggregation assay

Peri-operative diagnosis and treatment of platelet disorders

Surface Activation of Whole Blood: Clot Detection with a Thrombelastograph

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