Bleeding Complications in Patients With Budd-Chiari Syndrome on Anticoagulation

Jain, Abhinav; Shah, Chirag; Bhatt, Pratin; Meshram, Megha; Bhatia, Shobna; Shukla, Akash

doi:10.1016/j.jceh.2017.05.178

Cited by 2 publications

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“…30 Presence of hypocoagulant status at baseline in a subgroup of patients (as demonstrated in our study) could be one of the contributing reasons for high incidence of bleeding in patients with BCS despite normal INR and platelet count. 31 We excluded patients who had sepsis as TEG parameters are affected by presence of sepsis. Patients with decompensated cirrhosis and infection have been found to have a more hypocoagulable TEG, driven by endogenous heparinlike substances.…”

Section: Discussionmentioning

confidence: 99%

Patients With Budd–Chiari Syndrome Have Variable Coagulation Status on Thromboelastography at Diagnosis

Jain¹,

Dhore²,

Meshram³

et al. 2019

Journal of Clinical and Experimental Hepatology

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Section: Discussionmentioning

confidence: 99%

Patients With Budd–Chiari Syndrome Have Variable Coagulation Status on Thromboelastography at Diagnosis

Jain¹,

Dhore²,

Meshram³

et al. 2019

Journal of Clinical and Experimental Hepatology

Self Cite

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Anticoagulating Budd–Chiari syndrome patients presenting with variceal bleed: A retrospective study

Sharma

Goel

Moses

et al. 2020

J of Gastro and Hepatol

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Background and AimThis aims to study incidence of re‐bleeding on anticoagulation and survival of Budd–Chiari syndrome (BCS) patients presenting with variceal bleeding.MethodsBudd–Chiari syndrome patients presenting with variceal bleed between 01/01/2007 and 01/05/2019 were retrospectively studied. Patients underwent endoscopic treatment ± endovascular therapy, followed by anticoagulation. Variceal re‐bleed (on anticoagulation) and survival were studied.ResultsOf 376 BCS patients diagnosed during the study period, 40 (10.7%) patients, presenting with variceal bleed (age 33 [25–40] years; male patients 70%; Rotterdam score 1.13 [0.63–1.22]), Group 1 were compared with 40 randomly selected age‐matched BCS patients presenting with ascites, no bleeds (40 [23–42] years; male patients 42.5%; Rotterdam score 1.11 [1.09–1.16]), Group 2. The commonest site of obstruction was hepatic vein (65%) in Group 1 and combined hepatic veins and inferior vena cava (57.5%) in Group 2 (P < 0.01). Thirty‐six Group 1 patients underwent endoscopic intervention (variceal ligation, 33; sclerotherapy, 2; glue injection, 1). Endovascular intervention was performed in 30 Group 1 patients (angioplasty ± stent, 22; endovascular shunt, 8) and in 34 Group 2 patients (angioplasty ± stent, 26; endovascular shunt, 8). All 80 patients were started on anticoagulation. Variceal bleed on anticoagulation occurred in five patients in Group 1 and three patients in Group 2. One‐year and 5‐year survival were 94.2% and 87.5%, respectively, in Group 1 and 100% and 80%, respectively, in Group 2.ConclusionsAbout one‐tenth of BCS patients present with variceal bleed. On management with endoscopic ± endovascular therapy, followed by anticoagulation, variceal re‐bleed in these patients were comparable with those in BCS patients presenting with ascites and survival was excellent at 1 and 5 years.

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Bleeding Complications in Patients With Budd-Chiari Syndrome on Anticoagulation

Cited by 2 publications

References 0 publications

Patients With Budd–Chiari Syndrome Have Variable Coagulation Status on Thromboelastography at Diagnosis

Patients With Budd–Chiari Syndrome Have Variable Coagulation Status on Thromboelastography at Diagnosis

Anticoagulating Budd–Chiari syndrome patients presenting with variceal bleed: A retrospective study

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