thorough preoxygenation with 100% oxygen for several minutes prior to each application, limiting the flow and the duration of the treatment bursts, and rapidly correcting the resulting hypoxemia using intermittent jet ventilation with 100% oxygen.In addition to the risk of hypoxemia, the massive gas expansion has the potential for causing barotrauma. Protection against barotrauma necessitates strict observance of unobstructed passive ventilation. This requires the use of a large (48.5) endotracheal tube when a flexible bronchoscope is used to allow for effective unobstructed passive release of the volatized liquid nitrogen.Another rare risk of the procedure is the development of unpredictable life-threatening hemodynamic instability following endobronchial LNSCT, which was thought to be due to pulmonary venous gaseous emboli into the heart, coronary arteries, and systemic circulation. 4 Effective communication between the anesthesiologist and the pulmonologist is critical for mitigating and dealing with the risks of LNSCT. References 1 Krimsky WS, Rodrigues MP, Malayaman N, et al. Spray cryotherapy for the treatment of glottis and subglottic stenosis. Laryngoscope 2010;120:473-7. 2 Browning R, Turner JF, Parrish S. Spray cryotherapy (SCT): Institutional evolution of techniques and clinical practice from early experience in the treatment of malignant airway disease. J Thorac Dis 2015;7:S405-14. 3 DiBardino DM, Lanfranco AR, Haas AR. Bronchoscopic cryotherapy. Clinical applications of the cryoprobe, cryospray, and cryoadhesion. Ann Am Thorac Soc 2016;13:1405-15. 4 Pedoto A, Desiderio DP, Amar D, et al. Hemodynamic instability following airway spray cryotherapy.