Bleaching earth clay (pH 12.5)/PEG-400: an efficient recyclable catalytic system for synthesis of 5,6,7,8-tetrahydroquinoline-3-carbonitrile derivatives

Mogle, Pratima P.; Kamble, Rahul D.; Hese, Shrikant V.; Dawane, Bhaskar S.

doi:10.1007/s11164-014-1842-z

Cited by 4 publications

(3 citation statements)

References 40 publications

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“…These facts create vital interest of researcher to develop a competent method for their synthesis. As a part of our efforts for the development of green methodology for synthesis of biologically important scaffolds [37][38][39][40][41][42][43][44], herein we report microwave assisted MCR for synthesis of new 6-(4-substituted-phenyl)-3-methylimidazo[2,1-b]thiazole-2carbohydrazide derivatives.…”

Section: Methodsmentioning

confidence: 99%

Microwave assisted multicomponent reaction: An environmentally benign protocol for the synthesis of substituted imidazo[2,1-b]thiazole-2-carbohydrazide derivatives under solvent free condition

et al. 2016

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The present report describes a microwave assisted convenient and efficient protocol for the synthesis of new 6-(4-substituted-phenyl)-3-methylimidazo[2,1-b]thiazole-2-carbohydrazide derivatives. The current method holds a tag of green synthesis by virtue of catalyst and solvent free media. Moreover, the procedure offers excellent yield and purity of the products under mild condition compared with conventional method.

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Section: Methodsmentioning

confidence: 99%

Microwave assisted multicomponent reaction: An environmentally benign protocol for the synthesis of substituted imidazo[2,1-b]thiazole-2-carbohydrazide derivatives under solvent free condition

et al. 2016

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“…СИНТЕЗ 2-АМИНОПИРИДИН-3-КАРБОНИТРИЛОВ Для синтеза 2-аминопиридин-3-карбонитрилов, близких по строению 2-аминопиран-3-карбонитрилам, также широко применяется мультикомпонентная конденсация с использованием карбонильных соединений, малонодинитрила и аминирующих агентов (ацетат аммония, ароматические амины и значительно реже гетероциклические) [16][17][18][19]. Образование 2-аминопиридин-3-карбонитрилов при использовании ацетата аммония протекает через формирование пиранового интермедиата с его рециклизацией в соответствующий дигидропиридин с последующей окислительной ароматизацией.…”

Section: схема 3 Schemeunclassified

Methodology of «green» Chemistry in the Synthesis of Substituted 2-Aminopyranes (Pyridine) -3-Carbonitrile

2022

Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol.

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Numerous studies in the chemistry of heterocyclic compounds today are devoted to solving environmental and economic problems (environmental pollution, irrational use of natural re-sources, etc.). This mini-review summarizes and analyzes the literature data of the last 10 years (2011-2021) on the «green» synthesis of structurally similar 2-aminopyrans (pyridine) -3-carboni-triles (polysubstituted, annelated with different types of articulation of rings, spirocyclic) contain-ing in the heteroring, substituent groups (functional analogs), identical in nature (CN, NH2) and position (at C2 -C3), are similar in production methods, formation routes. The main «green» ap-proach to the synthesis of 2-aminopyran (pyridine)-3-carbonitriles is multicomponent condensa-tion during thermal, ultrasonic, microwave activation, and electrolysis. Reagents in the synthesis of 2-aminopyran-3-carbonitriles are malononitrile, (di) carbonyl compounds (aromatic, alicyclic, aliphatic), phenols, hydroxynaphthols, in the case of 2-aminopyridine-3-carbonitriles -malonodi-nitrile, carbonyl compounds, aminating agents (ammonium acetate, aromatic and heterocyclic amines). Numerous studies devoted to the search for catalysts that can replace toxic catalysts (ali-phatic, heterocyclic amines), which are used repeatedly with the same effectiveness. Promising cat-alysts that meet these requirements have been found -nano-, nanomagnetic, organic, solid hetero-geneous catalysts (based on silicon oxide, titanium oxide, graphene). Much attention is paid to the selection of environmentally friendly solvents, available, cheap (water, ethanol), the use of ionic liquids. Electrochemical synthesis is recognized as «green» because toxic catalysts are replaced by electric current. A series of electrosynthesis reactions of annelated, spiro-fused, polyheteroatomi-cheterosystems obtained in the nanoscale range is presented. A large number of publications over the past decade have shown that the methodology of «green» chemistry provides a low-step, effi-cient, low-waste pathway for the synthesis of substituted 2-aminopyran (pyridine) -3-carbonitriles, which corresponds to the PASE (Pot-Atom-Step-Econiomic) principle. It should be noted that this path is not devoid of disadvantages, such as the use of expensive catalysts and complex hardware design. From a huge number of publications over the last decade on the synthesis of 2-aminopyran (pyridine) -3-carbonitriles, only those concerning the use of the methodology of «green» chemistry, the most significant and informative (21 publications) were selected.

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“…Beyond MOF synthesis, polyethylene glycol (PEG) has been employed as an efficient "green solvent" for synthetic chemistry for many years, since it possesses a very low vapor pressure similar to ionic liquids, but is nontoxic and biodegradable [21,22]. PEG can dissolve a wide range of solutes as exemplified in intense recent research to employ PEG as a solvent for multi-component ("one-pot") synthesis reactions [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42]. Even mineral salts may be soluble in PEG [43].…”

Section: Introductionmentioning

confidence: 99%

Microwave Assisted Surfactant-Thermal Synthesis of Metal-Organic Framework Materials

et al. 2020

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This research explores the application of surfactants as green solvents for the rapid microwave synthesis of metal-organic framework (MOF) materials. Lead, copper, and iron metal-organic framework materials were synthesized using surfactant-thermal microwave synthesis. The MOF materials were characterized by powder X-ray diffraction, infrared spectroscopy, scanning electron microscopy, and thermogravimetric analysis. With the exception of the iron MOF, which was expected to be amorphous, the MOF materials are crystalline, though generally exhibiting smaller crystals than those achieved with traditional solvothermal synthesis. This green synthetic method reduced synthesis time and reduced the use of traditional organic solvents as the reaction media.

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Bleaching earth clay (pH 12.5)/PEG-400: an efficient recyclable catalytic system for synthesis of 5,6,7,8-tetrahydroquinoline-3-carbonitrile derivatives

Cited by 4 publications

References 40 publications

Microwave assisted multicomponent reaction: An environmentally benign protocol for the synthesis of substituted imidazo[2,1-b]thiazole-2-carbohydrazide derivatives under solvent free condition

Microwave assisted multicomponent reaction: An environmentally benign protocol for the synthesis of substituted imidazo[2,1-b]thiazole-2-carbohydrazide derivatives under solvent free condition

Methodology of «green» Chemistry in the Synthesis of Substituted 2-Aminopyranes (Pyridine) -3-Carbonitrile

Microwave Assisted Surfactant-Thermal Synthesis of Metal-Organic Framework Materials

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