Blastomycosis of Bone

Abstract

Blastomycosis osteomyelitis should be considered in the differential diagnosis of bone tumor, particularly when there is history of residence or travel in endemic areas. This disease can be correctly identified at frozen section, thus offering rapid diagnosis. There is an excellent correlation between morphologic and microbiologic studies.

Clinical Manifestations and Treatment of Blastomycosis

“…Osseous lesions are painful and can be associated with soft tissue abscess, draining sinus tracts, or cutaneous ulcers. 53 Osseous invasion of Blastomyces is characterized by lytic destruction, periosteal reaction or sclerotic margins on radiography and granulomatous inflammation on histopathology. 53,54 While any bone can be infected, the most common sites include the long bones, vertebrae, skull and ribs.…”

“…53 Osseous invasion of Blastomyces is characterized by lytic destruction, periosteal reaction or sclerotic margins on radiography and granulomatous inflammation on histopathology. 53,54 While any bone can be infected, the most common sites include the long bones, vertebrae, skull and ribs. 44,53,54 Blastomycosis of the bone can mimic malignancy (e.g., sarcoma, giant cell tumor, metastases) and Pott’s disease (Mycobacterium tuberculosis ).…”

“…53,54 While any bone can be infected, the most common sites include the long bones, vertebrae, skull and ribs. 44,53,54 Blastomycosis of the bone can mimic malignancy (e.g., sarcoma, giant cell tumor, metastases) and Pott’s disease (Mycobacterium tuberculosis ). 53,54 Through direct extension, infection can spread from bones to nearby joints and soft tissue resulting in septic arthritis and abscess, respectively.…”

“…44,53,54 Blastomycosis of the bone can mimic malignancy (e.g., sarcoma, giant cell tumor, metastases) and Pott’s disease (Mycobacterium tuberculosis ). 53,54 Through direct extension, infection can spread from bones to nearby joints and soft tissue resulting in septic arthritis and abscess, respectively. 53,54 Progressive bone destruction can result in pathologic fracture (e.g., vertebral body collapse).…”

“…53,54 Through direct extension, infection can spread from bones to nearby joints and soft tissue resulting in septic arthritis and abscess, respectively. 53,54 Progressive bone destruction can result in pathologic fracture (e.g., vertebral body collapse). 54 …”