Blastomycosis Misdiagnosed as Tuberculosis, India

Kumar, Anil; Kunoor, Akhilesh; Eapen, Malini; Singh, Pradeep Kumar; Chowdhary, Anuradha

doi:10.3201/eid2509.190587

Cited by 14 publications

(12 citation statements)

References 9 publications

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“…In fact, EPTB can show a variety of symptoms, which may be similar to those of other diseases such as lymphomas, solid tumours and infectious diseases. This brings further challenge to diagnosis of EPTB [9][10]. Therefore, clinicians need to consider the possibility of EPTB as a differential diagnosis.…”

Section: Discussion Conclusionmentioning

confidence: 99%

A Case of Pulmonary Tuberculosis Followed by Penicilliosis Marneffei without HIV Infection

Yang¹,

Xu²

2023

Preprint

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Background: Penicilliosis marneffei（P. Marneffei） is an important opportunistic pathogen found in in human immunodeficiency virus（HIV）-positive individuals. But there are few reports that tuberculosis （TB） patients are followed by P. Marneffeiwithout HIV Infection. Case presentation:A female patient, aged 45, admitted to a local hospital in 2008 due to fever and cough. The patient received transbronchial needle aspiration under bronchoscopy, and the smear indicated positive for acid-fast bacilli. Therefore, the patient began to receive 2HRZE/7HR regimen on May 23, 2009 untill to February 2010. The patient returned to normal.On April 25,2014, the patient had fever again and received HRZEMfx regimen. Two weeks late, the patient still had fever. He received lymph node biopsy and was confirmed as P. Marneffeiby pathological examination, tissue culture and transmission electron microscopy analysis. Multiple HIV tests were all negative.Patient’s fever subsided after intravenous infusion of voriconazole for 2 weeks, and the patient recovered after oral administration of the same dose of voriconazole tablets for 6 months. Conclusions: After the regular anti-TB treatment and stability, TB patients again have the clinical manifestations such as fever, swollen lymph nodes, etc. We cannot simply consider TB recurrence or resistance. Clinicians need to consider the possibility of infection with other pathogens.

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Section: Discussion Conclusionmentioning

confidence: 99%

A Case of Pulmonary Tuberculosis Followed by Penicilliosis Marneffei without HIV Infection

Yang¹,

Xu²

2023

Preprint

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“…However, pathogens that survived initial immune assaults can persist and replicate in macrophages. 85,86 These intracellular infections cause pulmonary infiltrate with granulomas, accompanying necrosis and fibrosis in adjacent tissues. 87,88 Although B. dermatitidis and M. tuberculosis are sequestered in granulomas, these microbes can be reactivated by dysregulation of host immune system.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Mycosis Drives Forkhead Box Protein A2 Degradation and Mucus Hypersecretion through Activation of the Spleen Tyrosine Kinase–Epidermal Growth Factor Receptor–AKT/Extracellular Signal-Regulated Kinase 1/2 Signaling

Choi

Yang

Sieve

et al. 2021

The American Journal of Pathology

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“…Anil kumar et al, reported a similar case where a 32-year-old man who returned to India after visiting Chicago, Illinois, and was treated for TB for 12 months before being diagnosed with blastomycosis [5]. Matthew et al, also reported a similar case where year old male from Mississippi river valley with complaints of haemoptysis, fatigue, weight loss, and fever and CT chest showing a large cavitary lesion in the right upper lobe.…”

Section: Journal Of Case Reports and Studiesmentioning

confidence: 98%

Disseminated Blastomycosis: A Case Report

LJ¹

2021

Journal of Case Reports and Studies

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Blastomycosis is known for its propensity to mimic other illnesses, which often leads to incorrect or delayed treatment.Here we present a case report of a patient working in Wisconsin who was misdiagnosed as Tuberculosis since he was an Indian. The patient was not evaluated on endemic grounds for Blastomyces where he was working for couple of years. After he developed skin lesions along with increased shortness of breath, lesions were evaluated which showed large yeast cells resembling Blastomyces. The treating pulmonologist evaluated his occupational history and was revealed with endemicity for Blastomyces.

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Blastomycosis Misdiagnosed as Tuberculosis, India

Cited by 14 publications

References 9 publications

A Case of Pulmonary Tuberculosis Followed by Penicilliosis Marneffei without HIV Infection

A Case of Pulmonary Tuberculosis Followed by Penicilliosis Marneffei without HIV Infection

Pulmonary Mycosis Drives Forkhead Box Protein A2 Degradation and Mucus Hypersecretion through Activation of the Spleen Tyrosine Kinase–Epidermal Growth Factor Receptor–AKT/Extracellular Signal-Regulated Kinase 1/2 Signaling

Disseminated Blastomycosis: A Case Report

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