Blastomycosis

Schwarz, Jan; Baum, Gerald L.

doi:10.1093/ajcp/21.11.999

Cited by 161 publications

(35 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…dermatitidis initiates disease as a pulmonary infection and frequently disseminates to sites such as the skin, thus the name B. dermatitidis (28). Hence, innate immunity in the pulmonary compartment must play an important role in the first line of defense against B. dermatitidis.…”

Section: Discussionmentioning

confidence: 99%

“…Interaction of the thermally dimorphic pulmonary fungal pathogen Blastomyces dermatitidis (28) with the first line of host defense, i.e., innate defenses, can critically influence the outcome of the infection. Innate production of proinflammatory cytokines and chemokines by stimulated macrophages promotes subsequent adaptive immune responses necessary for control of the infection (11,21).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Evasion of Innate Immune Responses: Evidence for Mannose Binding Lectin Inhibition of Tumor Necrosis Factor Alpha Production by Macrophages in Response toBlastomyces dermatitidis

et al. 2008

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Evasion of Innate Immune Responses: Evidence for Mannose Binding Lectin Inhibition of Tumor Necrosis Factor Alpha Production by Macrophages in Response toBlastomyces dermatitidis

et al. 2008

View full text Add to dashboard Cite

“…2,3 . Cases of mycotic abscesses have been reported due to Aspergillus 20,21 , Candida 22 , coccidiodomycosis 23 , histoplasmosis 24 and blastomycosis 25 . In contrast to bacterial pituitary abscesses, most fungal infections are associated with some type of immunosuppressed patients 18 .…”

Section: Discussionmentioning

confidence: 99%

Primary pituitary abscess: case report

Hanel

Koerbel

Prevedello

et al. 2002

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

-Pituitary abscesses are potentially life-threatening lesions if not appropriately diagnosed and treated. The authors have operated on more than five hundred cases of pituitary tumors and only one represented a case of pituitary abscess. A 35-year-old woman was investigated for chronic frontal headache. CT scan showed a cystic sellar lesion with ring enhancement after contrast injection leading to an initial diagnosis of pituitary adenoma. She underwent a sublabial transsphenoidal approach to the pituitary gland. After dural opening, purulent material was obtained and no tumor or other associated lesion was detected. There was no evidence of current or previous septicemic illness, meningitis, cavernous sinus thrombosis or sinus infection. Cultures were negative. She was put on antibiotics and discharged after 4 weeks. Nowadays, 10 years after treatment, she is doing well, with no anterior pituitary hormone deficit. MRI shows a partially empty sella without residual lesion and the pituitary stalck is in the midline. The early diagnosis and adequate treatment of this life-threatening lesion may result in excellent prognosis.KEY WORDS: abscess, pituitary gland, hypophysis. Abscesso primário de hipófise: relato de casoRESUMO -Abscessos pituitários são lesões potencialmente graves se não diagnosticadas e tratadas de maneira apropriada. Os autores têm mais de 500 casos de tumores pituitários operados e apenas um único caso de abscesso pituitário. Uma mulher de 35 anos foi investigada por cefaléia frontal crônica. A tomografia computadorizada de crânio mostrou uma lesão selar cística com captação de contraste levando à hipótese diagnóstica inicial de adenoma hipofisário. A paciente foi submetida a um acesso sublabial transesfenoidal para a hipófise. Após abertura dural, foi encontrado material purulento sem sinal de tumor ou outra lesão associada. Não havia evidência de doença séptica prévia ou atual, meningite, trombose de seio cavernoso ou sinusite. Culturas foram negativas. A paciente foi submetida a tratamento com antibióticos e recebeu alta após 4 semanas. Atualmente, após 10 anos do tratamento, encontra-se sem déficit hormonal hipofisário anterior. Sua ressonância magnética de crânio mostra uma sela parcialmente vazia sem lesão residual, com o talo hipofisário na linha média. O diagnóstico e tratamento adequado desta lesão potencialmente grave pode resultar em excelente prognóstico. PALAVRAS-CHAVE: abscesso, glândula pituitária, hipófise.

show abstract

“…Blastomycosis dermatitidis is endemic in Midwest states around the Great Lakes, the southeast, and the south central United States 1,2 . Humans acquire this fungus by inhalation of spores from the soil, usually in rural settings 3 . Infection by blastomycosis is most frequently found in adults aged 20-50 years 4,5 , with annual incidence reported in up to 100 cases per 100,000 people in specific areas of the United States 6 .…”

Section: To the Editormentioning

confidence: 99%