Blastic natural killer cell lymphoma/leukemia (CD56‐positive blastic tumor)

Abstract

We performed cytological examination of urethral brushing to study aberrant E‐Cadherin expression as a possible marker for papillomavirus in cytological samples. A total of 30 cytobrush male urethral smears were examined E‐cadherin expression and human papillomavirus (hpv) was confirmed using PCR‐DNA. The age range was 19–36 years (mean: 27 years), 17 (56.7%) cases corresponded to low‐risk HPV and 13 (43.3%) cases were high‐risk HPV. The mean age ranges were 25.77 ± 5.90 years for high‐risk HPV and 26.77 ± 4.31years for low‐risk HPV. Pap smears showed dyskeratosis in 23 (76.7%) cases, koilocytes in 13 (43.3%) cases, infection or bacterial background in 14 (43.7%) cases, suggestive changes of Gardnerella infection in 7 (23.3%) cases, and Chlamydia in 3 (10%) cases. Immunohistochemistry was positive for membrane E‐Cadherin; there was weak expression in 13 (43.3%) cases, moderate expression in 11 (36.7%) cases (P = 0.109) (Figs. 3a and b), and strong expression in 6 (20%) cases. There were a statistically significant correlations between E‐Cadherin expression and koilocytes (P = 0.007), individual cell dyskeratosis (P = 0.041), and HPV risk (P = 0.000). We concluded that the loss of E‐Cadherin membrane expression was greater in high‐risk HPV cases and was associated with individual cell dyskeratosis features and koilocytes. There were statistically significant correlations between E‐Cadherin expression and dyskeratosis (P = 0.043), koilocytes (P = 0.007), and type of HPV (P = 0.000). Using male urethral smears to test for the loss of E‐Cadherin membrane expression is simple, rapid, specific and more sensitive than conventional morphologic observations. We concluded that E‐Cadherin can be used to discriminate between high‐ and low‐risk papillomavirus in urethral cytologic specimens. Diagn. Cytopathol. 2010;38:583–589. 2009 Wiley‐Liss, Inc.

Blastic plasmacytoid dendritic cell neoplasm. A case report

“…The survival time may be associated with the tumor stage and the age and clinical manifestations of the patient (25,26).…”

Natural Killer Cell Leukemia: Diagnosis, Pathogenesis and Treatment

“…The nonsense mutation, C7412A, resulting in S2471X, where X is a terminal codon, in the PEST domain of NOTCH1 were observed, suggesting a possible role in the leukemogenesis of MNKL. In addition, CD7+ and CD56+ myeloid/natural killer cell precursor acute leukemia was proposed (Suzuki, 1997;Suzuki, 2005, Piichowska, 2007. Striking extramedullary involvement was evident at initial presentation, with peripheral lymphadenopathy and/or mediastinal masses.…”

Plasmacytoid dendritic cell tumor: A case report

“…Plasmacytoid dendritic cell tumors generally occur in middle-aged and elderly men; the skin is usually the first site of presentation in 90% of patients [1,4]. Additionally, there is a high incidence of lymph node and bone marrow involvement [1,9,11,12]. The tumor is characterized by a monotonous infiltrate of mediumsized cells with fine chromatin, resembling a lymphoblast.…”

“…The overlying epidermis is not affected and there is a well-preserved grenz zone. Prognosis is poor and overall survival is <2 years [11][12][13][14].…”