Blast-related ear injuries among U.S. military personnel

Dougherty, Amber L.; MacGregor, Andrew J.; Han, Peggy; Viirre, Erik; Heltemes, Kevin J.; Galarneau, Michael R.

doi:10.1682/jrrd.2012.02.0024

Cited by 64 publications

(43 citation statements)

References 26 publications

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“…Experimental studies have investigated the neurodegenerative process that has been observed in both the hippocampus and auditory system. Blast injury, which is a common etiology for sensorineural hearing loss and tinnitus ( Dougherty et al, 2013 ), causes dysfunction of the microtubule-associated protein, tau. Du et al (2016 , 2017 ) have found that blast-induced tau accumulates in the rat hippocampus and neurons in both the peripheral and central auditory systems, spanning from the spiral ganglion to the auditory cortex ( Du et al, 2016 , 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Smaller Hippocampal Volume and Degraded Peripheral Hearing Among Japanese Community Dwellers

Uchida

Nishita

Kato

et al. 2018

Front. Aging Neurosci.

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A growing body of literature has demonstrated that dementia and hearing loss are interrelated. Recent interest in dementia research has expanded to brain imaging analyses with auditory function. The aim of this study was to investigate the link between hearing ability, which was assessed using pure-tone audiometry, and the volume of brain regions, specifically the hippocampus, entorhinal cortex, Heschl’s gyrus, and total gray matter, using Freesurfer software and T1-weighted brain magnetic resonance imaging. The data for 2082 samples (age range = 40–89 years) were extracted from a population-based cohort of community dwellers. Hearing-impaired individuals showed significantly smaller hippocampal volumes compared with their non-hearing-impaired counterparts for all auditory frequency ranges. In addition, a correlational analysis showed a significant dose-response relationship for hearing ability and hippocampal volume after adjusting for potential confounding factors so that the more degraded the peripheral hearing was, the smaller the hippocampal volume was. This association was consistent through the auditory frequency range. The volume of the entorhinal cortex, right Heschl’s gyrus and total gray matter did not correlate with hearing level at any frequency. The volume of the left Heschl’s gyrus showed a significant relationship with the hearing levels for some auditory frequencies. The current results suggested that the presence of hearing loss after middle age could be a modifier of hippocampal atrophy.

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Section: Discussionmentioning

confidence: 99%

Smaller Hippocampal Volume and Degraded Peripheral Hearing Among Japanese Community Dwellers

Uchida

Nishita

Kato

et al. 2018

Front. Aging Neurosci.

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“…The pathology of hidden hearing loss is closely related to the pathogenesis of tinnitus 26 28 and hyperacusis 29 . Therefore, our present model is valuable for analyzing the etiologies of tinnitus or hyperacusis, which are the most frequent symptoms after blast injury 6 11 30 31 .…”

Section: Discussionmentioning

confidence: 99%

Pathophysiology of the inner ear after blast injury caused by laser-induced shock wave

Niwa

Mizutari

Matsui

et al. 2016

Sci Rep

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The ear is the organ that is most sensitive to blast overpressure, and ear damage is most frequently seen after blast exposure. Blast overpressure to the ear results in sensorineural hearing loss, which is untreatable and is often associated with a decline in the quality of life. In this study, we used a rat model to demonstrate the pathophysiological and structural changes in the inner ear that replicate pure sensorineural hearing loss associated with blast injury using laser-induced shock wave (LISW) without any conductive hearing loss. Our results indicate that threshold elevation of the auditory brainstem response (ABR) after blast exposure was primarily caused by outer hair cell dysfunction induced by stereociliary bundle disruption. The bundle disruption pattern was unique; disturbed stereocilia were mostly observed in the outermost row, whereas those in the inner and middle rows stereocilia remained intact. In addition, the ABR examination showed a reduction in wave I amplitude without elevation of the threshold in the lower energy exposure group. This phenomenon was caused by loss of the synaptic ribbon. This type of hearing dysfunction has recently been described as hidden hearing loss caused by cochlear neuropathy, which is associated with tinnitus or hyperacusis.

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“…The EMED is designed to collate information from multiple points of care for each subject, beginning on the battlefield and contiguous battalion aid stations and culminating with military treatment facilities (MTFs) that provide tertiary care [38]. Variables contained in the EMED include date of injury, Abbreviated Injury Scale (AIS) score, Injury Severity Score, mechanism of injury (e.g., blast, gunshot wound), description of injury, and International Classification of Diseases-9th Revision (ICD-9) code of clinical diagnosis.…”

Section: Injury Datamentioning

confidence: 99%

Development of a comprehensive Blast-Related Auditory Injury Database (BRAID)

Joseph¹,

Horton

Clouser

et al. 2016

J Rehabil Res Dev

Self Cite

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Abstract-The Department of Defense Hearing ConservationProgram provides specific guidance for service components to prevent occupational hearing loss; however, it does not specifically contend with the unique noise exposures observed in the theater of war, such as blasts and explosions. In order to examine the effects of blast injury on hearing sensitivity, we developed a large database composed of demographic, audiometric, point of injury, and medical outcome data, with the primary aim of developing a long-standing and integrated capability for the surveillance, assessment, and investigation of blast-related hearing outcomes. Methods used to develop the dataset are described. Encompassing more than 16,500 Navy and Marine Corps personnel, the Blast-Related Auditory Injury Database (BRAID) includes individuals with a blast-related injury and nonblast control subjects. Using baseline and postdeployment hearing threshold data, a retrospective analysis of the cohort revealed that the rate of hearing loss for the injured servicemembers was 39%. The BRAID will be useful for studies that assess hearing patterns following deployment-related injury, such as blast exposures, that facilitate exploration of health outcomes and whether they are predictive of audiometric disposition and that help establish hearing loss prevention strategies and program policies for affected military commands and servicemembers.

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Blast-related ear injuries among U.S. military personnel

Cited by 64 publications

References 26 publications

Smaller Hippocampal Volume and Degraded Peripheral Hearing Among Japanese Community Dwellers

Smaller Hippocampal Volume and Degraded Peripheral Hearing Among Japanese Community Dwellers

Pathophysiology of the inner ear after blast injury caused by laser-induced shock wave

Development of a comprehensive Blast-Related Auditory Injury Database (BRAID)

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