Blast from the past: Perioperative use of the Maruyama computer program for prediction of lymph node involvement in the surgical treatment of gastric cancer following neoadjuvant chemotherapy

Signature and Prediction of Perigastric Lymph Node Metastasis in Patients with Gastric Cancer and Total Gastrectomy: Is Total Gastrectomy Always Necessary?

“…We systematically explored the signature of pLNMs in relation to tumor location, tumor size, T stage, and lymphatic invasion, and showed that the combinations of tumor location with tumor size, T stage, and lymphatic invasion may determine the risk of pLNM, and may provide evidence to aid the appropriate selection of surgical procedures. Although various previous methods, including CT [ 5 ], DNA methylation markers [ 6 ], and the MCP [ 11 ], have been used to predict LNMs in patients with GC, the predicted LNMs were not station-specific and further investigations are therefore required. Here, we found that tumor size, T stage, lymphatic invasion, and the novel predictive factor, sDPD, were important predictors of pLNM.…”

“…Various procedures, including computed tomography (CT) [ 5 ], ultrasonography, magnetic resonance imaging with ferumoxtran-10 [ 6 ], and use of DNA methylation markers [ 7 ], have been explored to predict pLNMs prior to surgery; however, these have been inaccurate or complex, or have been unable to predict station-specific LNM [ 8 , 9 , 10 ]. Furthermore, the Maruyama Computer Program (MCP) was applied to predict LNMs in GC patients treated with neoadjuvant chemotherapy followed by gastrectomy [ 11 ]. However, the LNMs predicted by MCP were not station-specific and further investigations are therefore required.…”