Blaschkoid lichen planus: Throwing a “curve” in the nomenclature of linear lichen planus

Criscito, Maressa C.; Brinster, Nooshin; Skopicki, Debra L.; Seidenberg, Roy; Cohen, Jeffrey M.

doi:10.1016/j.jdcr.2020.01.001

Cited by 8 publications

(11 citation statements)

References 10 publications

(25 reference statements)

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“…It does not follow the distribution of blood vessels, lymph nodes, or nerves, but rather reflects the direction of spread of cell cloning and differentiation during embryonic development[ 3 ]. It is believed that LP along the Blaschko’s lines is found in 0.24%-0.62% of all LP patients[ 1 ], and nail LP affects approximately 10% of all patients with cutaneous LP[ 2 ]. In the published literature, cases of LP with unilateral distribution of lesions along the Blaschko’s lines mostly showed involvement of the trunk and limbs[ 1 , 4 - 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is believed that LP along the Blaschko’s lines is found in 0.24%-0.62% of all LP patients[ 1 ], and nail LP affects approximately 10% of all patients with cutaneous LP[ 2 ]. In the published literature, cases of LP with unilateral distribution of lesions along the Blaschko’s lines mostly showed involvement of the trunk and limbs[ 1 , 4 - 6 ]. Our patient had extensive lesions involving the right upper and lower limb and right side of chest, back and waist.…”

Section: Discussionmentioning

confidence: 99%

“…Although cases of lichen planus (LP) are not uncommon, LP with lesion distribution along the Blaschko’s lines is a rare entity, accounting for only 0.24%-0.62% of all patients with LP[ 1 ]. Cases with unilateral involvement of upper and lower limbs, chest, back, and waist are even rarer.…”

Section: Introductionmentioning

confidence: 99%

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Unilateral lichen planus with Blaschko line distribution: A case report

Dong¹,

Zhu²,

Xu³

et al. 2022

WJCC

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BACKGROUND Lichen planus (LP) with distribution of lesions along Blaschko’s lines is a rare entity, accounting for 0.24%-0.62% of all patients. Unilateral distribution of lesions in arm, leg, trunk, and waist is even less common. Approximately 10% of patients with LP manifest nail lesions. CASE SUMMARY A 20-year-old woman presented to our department with polygonal, purpuric, flat-topped papules over the right arm, right leg, and right side of trunk and waist for the last 5 mo. The patient initially developed nail deformation in the left middle finger with no obvious cause, followed by development of blue-purple and red maculopapular rash with pruritus. During the disease course, the skin lesions aggravated and spread to several segments due to scratching. The lesions showed unilateral distribution along the Blaschko’s lines. The diagnosis of LP along Blaschko’s lines was established based on dermoscopy and skin biopsy. Her cutaneous lesions considerably improved after 4-wk treatment with intramuscular glucocorticoid, oral acitretin, topical glucocorticoid, and retinoids. CONCLUSION Cases of LP involving multiple segments of the body along the Blaschko’s lines with nail damage are rare.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Unilateral lichen planus with Blaschko line distribution: A case report

Dong¹,

Zhu²,

Xu³

et al. 2022

WJCC

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“…Radiotherapy is known to have immunomodulatory properties. Exposure to low doses of radiation modulates the function of both macrophages and T lymphocytes and induces a selective enhancement of CD8+ T-cell responses [ 6 , 7 ]. LP after radiation has been described, but not a linear variety, and the previously reported case was believed to be a Koebner response.…”

Section: Discussionmentioning

confidence: 99%

“…In our patient, the role of radiotherapy was initially raised because of the localization at the irradiation site and the acquired character of the eruption. However, the extension of the lesions outside the irradiation site, with the average delay rules out the koebner phenomenon and pleads in favor of the immunomodulatory role of the radiotherapy and other factors (stress, drugs) [ 7 , 8 ]. In addition, breast imaging was performed to rule out tumor recurrence and paraneoplastic origin.…”

Section: Discussionmentioning

confidence: 99%

Blaschko-Linear Lichen Planus Pigmentosus: An Unusual Presentation

Eljazouly¹,

Agharbi²,

Alj³

et al. 2021

Cureus

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Lichen planus pigmentosus (LPP), an uncommon variant of lichen planus (LP), is characterized by diffuse hyperpigmented dark brown macules in sun-exposed areas. We report an unusual case of LPP with a blaschkoid distribution in an area of radiotherapy for breast cancer. This description is rarely reported. Its pathogeny is poorly understood and suggests an embryological origin by genetic mosaicism and also discusses the immunomodulatory role of radiotherapy in the disease.

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