“…Cardiac catheterization can be performed safely in young patients on ECMO, with a fairly low risk of major complications (most commonly bleeding and myocardial perforation), ranging from 3% to 7% in two medium-sized series (3,4). Percutaneous decompression of the left heart on ECMO has been accomplished in pediatric and young adult patients through a variety of techniques including balloon atrial septostomy under transthoracic (5) and transesophageal (6) echocardiographic guidance, combined blade and balloon atrial septostomy under fluoroscopic guidance (7), and both transseptal (8) and transaortic (9) left ventricular sheath placement. Ward et al (10) described a single case of transesophageal echo-guided transseptal left atrial decompression via a sheath connected in-line into the venous return limb of the ECMO circuit in a 16-month-old child.…”