Bladder Regeneration Following Subtotal Cystectomy

Liang, Daniel S.

doi:10.1016/s0022-5347(17)64833-x

Cited by 25 publications

(10 citation statements)

References 2 publications

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“…Bohne and his associates [8] noticed the bladder-like wall comprised of transitional epithelium with intermingled smooth muscle bundles around an acrylic mold 14 to 16 weeks after total cystectomy. Liang [9] reported that the patients, with 75% or more of the bladder removed and with a Foley catheter indwelling for 10 to 30 days, recovered a maximum of 125 to 300 cc of bladder capacity within 6 months. In their cases, measures to keep the urinary pouch distended, acrylic molds or Foley catheters, were adopted instead of substitution.…”

Section: Discussionmentioning

confidence: 99%

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Biodegradable material for bladder reconstruction

Agishi¹,

Nakazono²,

Kiraly³

et al. 1975

J. Biomed. Mater. Res.

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The objective of this study was to develop a biodegradable material for use in reconstructive surgery of the bladder to serve a temporary function until normal regrowth of the host's tissue is completed. The biodegradable material can serve as a base over which the new bladder can regenerate. At the conclusion of the regrowth of the new tissue, the temporary material could be consumed by the body and therefore not have to be removed. Material evaluation showed that 70% acetic anhydride treated bovine pericardium was digested and dissolved in 4 weeks when implanted subcutaneously in dogs. Based upon this, supplementation of the bladder using this material was performed on 5 dogs. One dog showed urinary leakage and was sacrificed after 1 week. In 3 dogs examined 4, 6, and 48 weeks after implantation, respectively, the implanted material had been dissolved. In one animal autopsied at 10.5 months, a small remnant of the material still remained. Post-operative observation of the animals, excretory pyelocystograms and cystometry confirmed that the material applied was useful for experimental urinary bladder supplementation.

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Section: Discussionmentioning

confidence: 99%

“…Liang [9] reported that an acceptable capacity of 125 to 300 cc is usually reached within 6 months after subtotal cystectomy. Stanley et al [3] mentioned that the regeneration process was completed between 9 and 18 months postimplantation in their nondissolvable prosthesis replacement.…”

Section: Discussionmentioning

confidence: 99%

Biodegradable material for bladder reconstruction

Agishi¹,

Nakazono²,

Kiraly³

et al. 1975

J. Biomed. Mater. Res.

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“…In rats, 8 weeks after removal of a major part of the bladder body by subtotal cystectomy, the bladder regenerated and regained its original capacity [Liang, 19631. This phenomenon has been applied clinically to augment the bladder capacity by subtotal cystectomy with or without insertion of a bladder mold [Bohne, 1957;Liang, 19621. Love reported that in one case with vesical necrosis, the bladder regenerated and the bladder regained normal capacity 6 months later [Love, 19781.…”

Section: Discussionmentioning

confidence: 99%

Functional effect of chronic ischemia on the rabbit urinary bladder

Lin

Wein

Gill

et al. 1988

Neurourology and Urodynamics

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The functional effect of partial ischemia of the rabbit urinary bladder was studied. Unilateral ischemia was created by ligation of one of the two vesical arteries that supply the rabbit bladder. The effect of 1-day, 1-, 2-, and 4-week chronic unilateral ischemia on in vivo and in vitro cystometry, and the functional response of the in vitro whole bladder model to field stimulation and bethanechol were determined. Within 1 day following the creabon of unilateral ischemia, the bladder became hyperreflexic with decreased compliance. This condition was observed in the 1-and 2-week groups. By 4 weeks, the hyperreflexia had decreased, and the compliance increased significantly. Peak pressure generation for in vitro whole bladder in response to field and bethanechol (500 pm) stimulation was maintained the same as control for all groups. However, the ability of the bladder to empty was diminished to about 50% of control values in the 1-day, 1-week, and 2-week groups. The ability to empty recovered to a significant degree by 4 weeks for both field stimulation and bethanechol. Our results show that the bladder function cannot be judged by pressure generation alone; a study of compliance and the ability to empty should be performed to give a true indication of the functional state of the bladder.

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“…In pioneering studies by Atala et al (2006), bladder neo-organs were constructed by seeding synthetic scaffolds (collagen or collagen/polyglycolic acid composites) with urothelial cells on the inside and smooth muscle cells on the outside and subsequently implanted into subjects with myelomeningocele. Numerous reports suggested that both animal (Liang and Goss, 1963;Oberpenning et al, 1999;Frederiksen et al, 2004;Burmeister et al, 2010) and human (Sisk and Neu, 1939;Liang, 1962;Tucci and Haralambidis, 1963) bladders have significant regenerative potential after removal of a large portion of the organ (subtotal cystectomy; STC).…”

Section: A Bladder Diseasementioning

confidence: 99%