Bladder Pain Syndrome (Interstitial Cystitis) and Related Disorders

Hanno, Philip M.

doi:10.1016/b978-1-4160-6911-9.00012-8

Cited by 41 publications

(75 citation statements)

References 757 publications

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“…Mast cells have been frequently reported to be associated with IC/BPS. 5 Yamada has reported that as many as 86% of 36 young study patients with IC/BPS had allergic complications. 6 There are also case reports of management of a patient's allergic disease concomitantly leading to relief of their IC/BPS symptoms.…”

Section: Original Researchmentioning

confidence: 99%

Multiple sensitivity phenotype in interstitial cystitis/bladder pain syndrome

Fuoco

Irvine-Bird²,

Nickel³

2014

CUAJ

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Cite as: Can Urol Assoc J 2014;8(11-12):e758-61. http://dx.doi.org/10.5489/cuaj.2031 Published online November 24, 2014. AbstractIntroduction: Phenotypic differentiation of patients with interstitial cystitis/bladder pain syndrome (IC/BPS) may improve our understanding of the condition, as well as the development of patientspecific treatment strategies. We identified a distinct subgroup of IC/BPS patients with a multiple sensitivity phenotype. Methods: We defined patients with this IC/BPS associated multiple sensitivity syndrome as having at least 3 confirmed allergies/sensitivities to medications and/or environmental factors and a diagnosis of IC/BPS. These IC/BPS patients identified with a multiple sensitivity phenotype (cases) were compared to agematched IC/BPS patients with few or no allergies (controls) at a 1:2 ratio. Comparisons were undertaken using standardized case assessment parameters (age, duration of symptoms, medical history, Interstitial Cystitis Symptoms Index [ICSI] and pelvic pain and urinary urgency/frequency [PUF] symptom scores, and urinary, psychosocial, organ specific, infection, neurologic/systemic, tenderness [UPOINT] categorization). Results: The study consisted of 17 cases and 34 age-matched controls; the mean age was 55 and 56 years, respectively. There was statistically more medication and environmental allergies in the cases versus controls. Cases reported more concomitant illnesses (9.6 vs. 6.2, p < 0.001) and number of bodily systems affected (6.0 vs. 3.8, p ≤ 0.001). The prevalence of irritable bowel syndrome and fibromyalgia was higher in the case group (p = 0.028, p ≤ 0.001, respectively). Additionally, there were more reported psychiatric diseases (p = 0.019), allergic/immune diseases (p = 0.003), and pulmonary diseases (p < 0.001) in the case group. UPOINT classification differed with more patients in the case group being categorized in the psychosocial and neuropathic/systemic domains (p = 0.045, p = 0.007, respectively). Total UPOINT classification (out of 6) was also higher in cases than controls (4.6 vs. 3.2, p = 0.001, respectively). Conclusions:We have characterized a distinct phenotypic group of patients with IC/BPS and multiple sensitivities. The limitations of our study include the retrospective case-control matching design, biases in phenotype definition, single centre patient recruitment,

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Section: Original Researchmentioning

confidence: 99%

Multiple sensitivity phenotype in interstitial cystitis/bladder pain syndrome

Fuoco

Irvine-Bird²,

Nickel³

2014

CUAJ

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“…IC/BPS is now viewed not only through the paradigm of chronic pain syndrome manifesting through bladder-related symptoms, but as a syndrome that may not only isolated to the bladder alone [17]. There may be many causes of chronic pelvic pain.…”

Section: New Paradigmmentioning

confidence: 99%

“…These pain syndromes include bladder, urethra, prostate, testicular, and epididymal pain syndromes. The types of BPS can be further defined as IC or simply categorized by ESSIC criteria [17,22].…”

Section: New Paradigmmentioning

confidence: 99%

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Is Urethral Pain Syndrome Really Part of Bladder Pain Syndrome?

Cho

2017

Urogenit Tract Infect

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Urethral pain syndrome is a symptom complex that includes dysuria, urinary urgency, frequency, nocturia, and persistent or intermittent urethral and/or pelvic pain in the absence of proven infection. Bladder pain syndrome is a clinical diagnosis, based primarily on chronic symptoms of pain from the bladder and/or pelvis associated with urinary urgency or frequency in the absence of identified cause for the symptoms. To date, the term, urethral pain syndrome, remains to be unclear in referring to a distinct subgroup of bladder pain syndrome. However, these two syndromes share many similarities, except the organ of pain. This review is intended to summarize the current state of literature with regard to similar pathophysiology and possible interrelations between urethral pain syndrome and bladder pain syndrome.

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“…While the research community struggles with nomenclature, there is no doubt that women with pelvic pain perceived to be bladder related and concomitant urinary storage symptoms are difficult to manage. The literature surrounding the only oral medication approved for this condition (approved for IC not BPS, a term not recognized by any regulatory organization) clearly shows that the benefits of PPS compared to placebo are at best modest in the short term, 3 however the longer the duration of exposure, the greater the predicted response rate. 4 Some problems and limitations with this study include that it was retrospective, patients who discontinued PPS prior to 3 months were not included, other treatments were not documented and the primary outcome measure was global response assessment which has not be validated for longterm studies and is likely very inaccurate after 3 months.…”

mentioning

confidence: 99%