Bladder Herpes Infection in a Patient With Low-grade Non–Muscle-invasive Bladder Cancer

Garrido-Abad, Pablo; Díaz-Menéndez, A.; Fernández-Arjona, Manuel

doi:10.1016/j.urology.2017.10.032

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Sfn In Bladder Cancer1

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2021

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“…The antitumor effect of SFN was associated with downregulation of both the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2/neu) [ 106 ]. This is remarkable, since inhibition of either EGFR or HER2 signaling has been shown to correlate with enhanced p38 MAPK phosphorylation [ 134 ]. Gemcitabine or cisplatin treatment in human bladder cancer models has been shown to cause a dose-dependent release of ROS and activate the p38 MAPK-signaling pathway [ 135 ].…”

Section: Sfn In Bladder Cancermentioning

confidence: 99%

Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma

Xie

Chun

Rutz

et al. 2021

IJMS

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Sulforaphane (SFN) is a natural glucosinolate found in cruciferous vegetables that acts as a chemopreventive agent, but its mechanism of action is not clear. Due to antioxidative mechanisms being thought central in preventing cancer progression, SFN could play a role in oxidative processes. Since redox imbalance with increased levels of reactive oxygen species (ROS) is involved in the initiation and progression of bladder cancer, this mechanism might be involved when chemoresistance occurs. This review summarizes current understanding regarding the influence of SFN on ROS and ROS-related pathways and appraises a possible role of SFN in bladder cancer treatment.

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Section: Sfn In Bladder Cancermentioning

confidence: 99%