Bladder filling inhibits somatic spinal motoneurones

Inghilleri, Maurizio; Carbone, Antonio; Pedace, F.; Conte, Antonella; Frasca, Vittorio; Berardelli, Alfredo; Cruccu, G.; Manfrēdi, M.

doi:10.1016/s1388-2457(01)00674-5

Cited by 13 publications

(19 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As previously described in a study from our group and an earlier study by others in patients with SCI [9,26], we found that at baseline, the H reflex size was unchanged or only slightly facilitated at maximum bladder filling and that after BoNT/A, it was slightly inhibited. The lack of an inhibitory effect during bladder filling on somatic spinal motoneurons is thought to depend on the removal of descending modulation relayed by reticulospinal pathways [27] on propriospinal interneurones.…”

Section: Discussionsupporting

confidence: 87%

Botulinum toxin A modulates afferent fibers in neurogenic detrusor overactivity

Conte

Giannantoni

Proietti

et al. 2011

Euro J of Neurology

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 87%

Botulinum toxin A modulates afferent fibers in neurogenic detrusor overactivity

Conte

Giannantoni

Proietti

et al. 2011

Euro J of Neurology

View full text Add to dashboard Cite

show abstract

“…This study extends previous investigations on the same topic (Inghilleri et al 2001;Carbone et al 2002;Palleschi et al 2014;Serrao et al 2014). The main results we obtained can be summarized as follows: (i) both NWR and its related pain perception were reduced only in the upper limbs; conversely, the H-reflex was inhibited in both limbs; (ii) NWR pain-related perception (NRS) was decreased in males in both limbs, while in females, no significant changes were observed in lower limbs; and (iii) no effects were found on the CSP duration.…”

Section: Discussionsupporting

confidence: 91%

“…Such an inhibitory effect may be exerted on the neural substrate mediating the NWR, i.e., the wide dynamic range neurons, which relay the neural inputs from several painful and no-painful afferents and is strongly modulated by descending pathways (Sandrini et al 2005). Bladder distension-induced inhibitory effect seems to occur also at the level the motoneurons, since the bladder filling reduces also the H-reflex magnitude (Inghilleri et al 2001). The overall inhibitory effect may represent a safety mechanism to maintain continence during painful stimuli and painrelated motor responses that may increase intra-abdominal pressure ).…”

Section: Introductionmentioning

confidence: 99%

Effect of high level of bladder filling on spinal nociception and motoneuronal excitability

et al. 2015

View full text Add to dashboard Cite

To verify whether high level of bladder distension may counteract the inhibitory effect of descending pathways on sacral spinal cord neurons and to investigate which spinal circuitries are possibly involved in such a viscero-somatic interaction. Nociceptive withdrawal reflex (NWR), cutaneous silent period (CSP), and H-reflex were recorded in both lower and upper limbs of twenty-eight healthy subjects. Subjects were examined during baseline (empty bladder, no voiding desire), high level of bladder filling (urgency desire), and control (empty bladder, no voiding desire) sessions. Results showed that the NWR and its related pain perception were reduced in the upper limbs, while only a pain perception reduction in males was observed in the lower limbs. The H-reflex was inhibited in both limbs. No effects were found on the CSP duration. The decrease in both the NWR and its related pain perception in the upper limbs confirms the presence of a bladder distension-induced descending inhibitory modulation on nociception at spinal level. The lack of a similar inhibitory effect in the lower limbs suggests that excitatory nociceptive inputs from bladder afferents counterbalance the inhibitory effect on sacral spinal cord. The lack of the descending inhibitory effect may be a mechanism aimed at forcing the micturition phase to avoid bladder damage caused by bladder sovradistension.

show abstract

“…If cross‐organ communication exists between colon and urinary bladder (6), bladder filling will produce similar effects of colorectal distension and inhibit the cutaneous nociceptive reflexes (ie, SNR). Our results confirm that visceral afferents may modulate and suppress spinal excitability in healthy humans (15–17). Inhibition could be one of the mechanisms of continence that holds urine within the bladder.…”

Section: Discussionsupporting

confidence: 82%