Bladder Control: Role of Higher Levels of the Central Nervous System

Morrison, J.

doi:10.1007/978-1-4471-1449-9_8

Cited by 28 publications

(25 citation statements)

References 82 publications

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“…Brainstem control of eliminative and sexual functions has been reviewed (Morrison, 1987;de Groat and Steers, 1990). In the present study, it is noteworthy that Barrington's nucleus, an area involved in micturition control, receives ascending projections only from neurons in the CC area at lumbosacral levels of the spinal cord.…”

Section: Functional Considerationsmentioning

confidence: 97%

Ascending projections from the area around the spinal cord central canal: APhaseolus vulgaris leucoagglutinin study in rats

Wang¹,

Willis²,

Westlund³

1999

J. Comp. Neurol.

117

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Section: Functional Considerationsmentioning

confidence: 97%

Ascending projections from the area around the spinal cord central canal: APhaseolus vulgaris leucoagglutinin study in rats

Wang¹,

Willis²,

Westlund³

1999

J. Comp. Neurol.

117

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“…In adult mammals, the micturition reflex is organized through afferent and efferent pathways that connect the urinary bladder and urethra to the lumbosacral spinal cord, brainstem, and higher brain centers (Kuru, 1965;Morrison, 1987;de Groat and Steers, 1990). Afferent impulses, coding the state of bladder fullness and originating from fibers embedded in the bladder body musculature, pass to the lumbosacral spinal cord via the pelvic and hypogastric nerves.…”

mentioning

confidence: 99%

“…The entire process is a complex, multilevel, and multineuronal interaction and involves facilitation and inhibition at many levels of the central nervous system (CNS). For review, see Morrison (1987). Although accumulation and appropriate emptying of urine from the urinary bladder may seem like an elementary process, much of the circuitry as well as the neurotransmitters involved is still unknown.…”

mentioning

confidence: 99%

Neurons in the rat brain and spinal cord labeled after pseudorabies virus injected into the external urethral sphincter

Nadelhaft¹,

Vera

1996

J. Comp. Neurol.

131

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Male Sprague-Dawley rats, with their pelvic and hypogastric nerves transected, were infected with pseudorabies virus (PRV) injected into the external urethral sphincter. Animals were sacrificed at 2, 2.5, 3, and 4 days postinfection. Spinal cord and brain tissue were sectioned and processed by immunohistochemical techniques with antisera against PRV and choline acetyl transferase (CAT). At 2 days postinfection, virus-labeled neurons were found in the ventrolateral divisions of Onuf's nucleus and in the dorsal gray commissure (DGC). At progressively later incubation times, labeled neurons were found in the intermediolateral regions, the superficial layer of the dorsal horn, and the brainstem, in particular, the pontine micturition center. PRV/CAT-positive neurons were only found in Onuf's nucleus. Preganglionic neurons in the L6-S1 intermediolateral regions were CAT positive but PRV negative, thus suggesting that they are interneurons, not sacral parasympathetic preganglionic neurons. After 4 days, virus had spread to neurons in the paraventricular, preoptic, and even cortical regions. The distribution of these PRV-labeled brain neurons strongly resembled that obtained after the injection of PRV into the urinary bladder (Nadelhaft et al. [1992] Neurosci. Lett. 143:271-274). In both cases, neurons were labeled in the DGC in the spinal cord. The data therefore suggest that neurons in the DGC may be involved in the integrated control of the bladder and the external urethral sphincter.

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“…Important among the mechanisms revealed in animal experiments has been the detail of cerebral control of the 'micturition reflex' (spino-bulbo-spinal (SBS) reflex) itself, a reflex involving afferents from the bladder impinging on various pontine nuclei of the brainstem. These nuclei give rise to descending excitatory and inhibitory pathways influencing the excitability of lumbar-sacral segmental reflexes controlling bladder and sphincter function (Morrison, 1987).…”

Section: R E F L E X M O D U L a T I O N Of B L A D D E R A C T I V Imentioning

confidence: 99%

Neuromodulation of the lower urinary tract

Craggs

McFarlane

1999

Experimental Physiology

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Bladder Control: Role of Higher Levels of the Central Nervous System

Cited by 28 publications

References 82 publications

Ascending projections from the area around the spinal cord central canal: APhaseolus vulgaris leucoagglutinin study in rats

Ascending projections from the area around the spinal cord central canal: APhaseolus vulgaris leucoagglutinin study in rats

Neurons in the rat brain and spinal cord labeled after pseudorabies virus injected into the external urethral sphincter

Neuromodulation of the lower urinary tract

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