Bladder Contractility Is Mediated by Different K+ Channels in the Urothelium and Detrusor Smooth Muscle

Santoso, Aneira Gracia Hidayat; Liang, Willmann

doi:10.1254/jphs.10162fp

Cited by 6 publications

(1 citation statement)

References 29 publications

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“…What are the possible modes of action of 4-AP that could explain the improvement in the contraction of the detrusor muscle described above in this patient with BPH? First, in animal studies the effects of different potassium channel blockers (e.g., 4-AP, glibenclamide, iberiotoxin, charybdotoxin, and apamin) on the urothelium and the detrusor smooth muscle that regulates bladder function, were investigated [ 7 ]. Both nonselective K + channel blockade and selective voltage-sensitive potassium blockade by 4-AP resulted in increased contraction on rat detrusor strips [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

4-Aminopyridine Improves Lower Urinary Tract Symptoms in a Patient With Benign Prostatic Hyperplasia and Downbeat Nystagmus Syndrome

et al. 2014

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Aminopyridines are potassium channel blockers that increase the excitability of nerve cells and axons; therefore, they are widely used to treat different neurological disorders. Here we present a patient with idiopathic downbeat nystagmus and lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia who was treated with the sustained-release form of 4-aminopyridine (4-AP). During treatment with 4-AP, the LUTS improved. This improvement was monitored by using uroflowmetry and the International Prostate Symptom Score. A significant improvement of symptoms was observed in relation to the voided volume. This included an improved emptying of the bladder without an increase in residual urine. In animal studies, both nonselective K+ channel blockade and selective voltage-sensitive potassium blockade by 4-AP resulted in increased contraction on rat detrusor strips. To our knowledge, this is the first clinical observation of the mode of action of 4-AP in urological symptoms in humans.

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Section: Discussionmentioning

confidence: 99%