Bladder carcinosarcoma treated by cystectomy and adjuvant chemotherapy with good outcomes: a case report

Kouhen, Fadila; Dahbi, Zineb; Afif, Mohammed; Chihabeddine, Meriem; Errafiy, Nadia; Oqbani, Kenza; Omor, Youssef; Elhossini, Amal

doi:10.1186/s13256-023-04028-3

Cited by 3 publications

(4 citation statements)

References 12 publications

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“…Due to the tumor's rarity, data in the literature are limited to case reports and limited series [8,11]. While several therapeutic techniques have been documented, the most effective treatment involves a multimodality approach [6]. The recommended treatments include TUR-BT, radical cystectomy, partial cystectomy with chemotherapy or radiotherapy, and neoadjuvant radiotherapy followed by radical cystectomy and adjuvant radiotherapy [5].…”

Section: Discussionmentioning

confidence: 99%

“…Urinary bladder carcinosarcomas have a terrible prognosis, with the majority of patients dying within one year of diagnosis [5]. The pathological stage is the primary predictor of survival, and regional and distant spread raises death rates [5,6]. Wang et al's study, which included 221 patients, found that the disease prognosis was mainly determined by the tumor stage at presentation.…”

Section: Discussionmentioning

confidence: 99%

“…Urinary bladder carcinosarcomas have a terrible prognosis, with the majority of patients dying within one year of diagnosis [5]. The pathological stage is the primary predictor of survival, and regional and distant spread raises death rates [5,6]. We report the case of a 74-year-old female who presented with intermittent hematuria and passage of clots and was subsequently diagnosed with urinary bladder carcinosarcoma.…”

Section: Introductionmentioning

confidence: 99%

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Urinary Bladder Carcinosarcoma (Sarcomatoid Carcinoma) With Long Survival After Transurethral Resection: A Case Report

Badheeb,

Alkhanbashi,

Al Hammadi

et al. 2024

Cureus

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Carcinosarcoma or sarcomatoid carcinoma of the urinary bladder is a rare but aggressive bladder cancer characterized by malignant epithelial and mesenchymal components, with only a few cases reported in the literature so far. In this report, we discuss a case of a 74-year-old female nonsmoker who presented with intermittent hematuria and passage of clots in the last four months. Radiographic images showed an irregular mass lesion (6.2 x 6 cm) in the left lateral wall of the urinary bladder near to left vesicoureteral junction. The mass was completely removed with transurethral resection of the bladder tumor (TUR-BT). Histopathological study revealed high-grade carcinosarcoma, and immunohistochemistry showed diffuse positivity for vimentin, pan-cytokeratin (CK) and CK7, epithelial membrane antigen (EMA), and CK5/6. The patient declined radical cystectomy and only agreed to receive intravesical chemotherapy (gemcitabine), and she remains alive after more than four years of follow-up.Carcinosarcoma of the urinary bladder is a rare tumor primarily affecting older people, and it is most commonly treated with radical cystectomy and different combination treatments such as chemotherapy and radiation. However, tumor resection followed by intravesical chemotherapy may be an alternative option in the early stages of bladder carcinosarcoma for some patients, thereby avoiding the need for aggressive treatments, especially for elderly patients who decline to undergo radical surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Urinary bladder carcinosarcomas have a terrible prognosis, with the majority of patients dying within one year of diagnosis [5]. The pathological stage is the primary predictor of survival, and regional and distant spread raises death rates [5,6]. We report the case of a 74-year-old female who presented with intermittent hematuria and passage of clots and was subsequently diagnosed with urinary bladder carcinosarcoma.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Urinary Bladder Carcinosarcoma (Sarcomatoid Carcinoma) With Long Survival After Transurethral Resection: A Case Report

Badheeb,

Alkhanbashi,

Al Hammadi

et al. 2024

Cureus

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“…[2] According to previous research, radical cystectomy and/or multimodal treatment (chemotherapy or radiotherapy) significantly reduces the risk of death compared to bladder preservation surgery. [3,4] However, guidelines related to this disease are limited because of the rare incidence and poor prognosis of bladder carcinosarcoma (BC).…”

Section: Introductionmentioning

confidence: 99%

Clinical evolution of bladder carcinosarcoma: A case report and literature review

Wu,

Wang,

Zuo

et al. 2024

Medicine

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Rationale: Bladder carcinosarcoma (BC) is a malignant tumor composed of a mixture of malignant epithelial and stromal components. Carcinosarcoma mostly occurs in the upper respiratory tract and upper gastrointestinal tract and is less common in the urinary system. The incidence of malignant tumors of the urinary system is <3%. It rarely occurs in the bladder and accounts for approximately 0.31% of all malignant bladder tumors. A literature review and this report will help to further improve our understanding, diagnosis, and treatment of bladder carcinosarcoma (BC). Patient concern: We describe the case of an 80-year-old female patient who was admitted to the hospital with a history of intermittent hematuria for 3 years. Furthermore, total cystectomy was refused when a BC was diagnosed. Palliative resection surgery was necessary because of the recurrent hematuria and abdominal pain. Diagnoses: Pathologically confirmed BC after surgery. Interventions: The patient’s first transurethral resection of bladder tumor (TURBT) was diagnosed as BC. However, the patient refused a total cystectomy. Two months after intravesical treatment with epirubicin, bladder tumor recurrence was observed during follow-up cystoscopy. The patient underwent a second TURBT for hemostatic treatment due to persistent hematuria. Due to hematuria and abdominal pain, a third TURBT was performed to reduce tumor size and stop bleeding. Finally, tumor recurrence resulted in bilateral hydronephrosis, and the patient underwent bilateral renal catheter drainage guided by B-ultrasound. Outcomes: Bladder carcinosarcoma caused uremia, electrolyte imbalance, and sepsis. Approximately 19 months after the discovery of the tumor, the patient died. Lessons: Radical bladder resection is recommended once a BC is diagnosed. By reporting the cases and reviewing the literature in the database, we will summarize the epidemiology, origin, etiology, clinical features, existing treatments, and prognostic factors of BC, and propose new prospects for BC therapy.

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Clinical efficacy analysis of partial cystectomy and radical cystectomy in the treatment of muscle-invasive sarcomatoid carcinoma of the urinary bladder

Xiao,

Chen,

et al. 2024

Front. Oncol.

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ObjectiveThis study compares the clinical efficacy of partial cystectomy (PC) versus radical cystectomy (RC) in the treatment of muscle-invasive bladder urothelial carcinoma (SCUB) through a retrospective analysis.MethodsWe retrospectively analyzed the clinical data of 20 patients diagnosed with muscle-invasive SCUB from July 2015 to August 2023 at Ganzhou People’s Hospital. All patients underwent surgical treatment followed by chemotherapy, with 9 receiving PC and 11 undergoing RC. We compared the average survival time of deceased patients for both treatments and conducted survival and multivariate analyses using the Kaplan-Meier method and Cox proportional hazards model, respectively.ResultsAll 20 patients were postoperatively diagnosed with muscle-invasive SCUB and were followed up for 4 to 60 months. The average survival time for patients undergoing PC was 11.5 months, with survival rates at 1 year, 2 years, and 5 years of 55.56%, 22.22%, and 11.11%, respectively. In contrast, patients receiving RC had an extended average survival time of 22.5 months, and their 1-year, 2-year, and 5-year survival rates increased to 63.64%, 36.36%, and 18.18%, respectively. Survival analysis revealed statistically significant differences in prognosis between PC and RC for the treatment of muscle-invasive SCUB (P<0.05).ConclusionSCUB is a rare malignant tumor with unique biological characteristics often associated with poor prognosis. Upon diagnosis, RC should be considered as an early treatment approach when the patient’s overall condition permits.

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Bladder carcinosarcoma treated by cystectomy and adjuvant chemotherapy with good outcomes: a case report

Cited by 3 publications

References 12 publications

Urinary Bladder Carcinosarcoma (Sarcomatoid Carcinoma) With Long Survival After Transurethral Resection: A Case Report

Urinary Bladder Carcinosarcoma (Sarcomatoid Carcinoma) With Long Survival After Transurethral Resection: A Case Report

Clinical evolution of bladder carcinosarcoma: A case report and literature review

Clinical efficacy analysis of partial cystectomy and radical cystectomy in the treatment of muscle-invasive sarcomatoid carcinoma of the urinary bladder

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