Bladder Cancer in Spinal Cord Injury Patients

Kalisvaart, Jonathan F.; Katsumi, Hiroshi; Ronningen, Leland D.; Hovey, Regina M.

doi:10.1016/s0022-5347(08)61036-8

Cited by 19 publications

(44 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies reported a higher incidence of tumours after long-term SPC, chronic bladder infections and bladder calculus. In contrast, a current study 16 with 32 bladder carcinoma patients out of 1319 SCI participants reviewed that more than 50% of these tumour patients never had a SPC or indwelling urethral catheter for a longer period. Under Discussion is the explanation, that the bladder paralysis itself is the risk factor for developing a malignant bladder tumour.…”

Section: Discussionmentioning

confidence: 71%

Quality of life and urological morbidity in tetraplegics with artificial ventilation managed with suprapubic or intermittent catheterisation

2011

View full text Add to dashboard Cite

Study design: Mono-centric, retrospective study. Objective: Analysis of correlation between bladder management and age in respirator-dependant high-tetraplegic patients. Additionally suprapubic catheter (SPC) and intermittent catheterisation (IC) were reviewed concerning urological complications and quality of life (QoL). Setting: Level 1 trauma centre. Methods: A QoL questionnaire 'International Consultation on Incontinence' (ICIQ-SF) was sent to 56 tetraplegic respirator devicedependant (RDD)-spinal cord injury (SCI) patients. Their scores concerning urological morbidity were reviewed. For analysis reasons they were divided in three groups: SPC, IC and others. Results: SPC 38, IC 12 and others 6 patients. Significant difference in age (SPC vs IC¼49.9 vs 31.8 years) was observed but no disparity in gender. Within a follow-up period 2-26 years (median 8 years) significant urological complications in patients with IC (Po0.05) were ascertained. These were in general minor complications. Especially renal deterioration or bladder cancer was not diagnosed in any of the group. The questionnaire return rate was high (83.9%) with complete answers (SPC¼32, IC¼11). Self assessment of QoL with ICIQ-SF revealed no significant difference for both groups on low level, but SPC patients tend to score better. Conclusion: In our study, tetraplegic RDD-SCI patients with SPC suffered less urological complications and tend to score a better QoL. Therefore we recommend SPC as a serious alternative for these selected patients and concurrently underline the necessity of close urological surveillance at least annually.

show abstract

Section: Discussionmentioning

confidence: 71%

Quality of life and urological morbidity in tetraplegics with artificial ventilation managed with suprapubic or intermittent catheterisation

2011

View full text Add to dashboard Cite

show abstract

“…The incidence varies from 0.39%, 24 which is comparable to the general population, to 2.4%. 22 While the rates of carcinoma vary substantially, all studies showed a strong association of prolonged catheterization with squamous cell carcinoma and adenocarcinoma of the bladder. [21][22][23][24] It is believed that squamous cell carcinoma arises through squamous metaplasia secondary to long-term irritation associated with catheterization and recurrent urinary tract infections.…”

Section: Discussionmentioning

confidence: 99%

“…20 Conflicting results have been published on the association of spinal cord injury and bladder carcinomas. Some studies report a 16-to 26-fold increased risk of cancer, 21,22 while other studies suggest that the risk is comparable to that of the general population. 23,24 Nevertheless, all groups convincingly show that squamous cell carcinoma of the bladder is overrepresented in this category of patients, comprising 19% 23 to 46.9% 21,22 of all bladder carcinomas; this is significantly higher than in the general population, where non-schistosomal squamous cell carcinoma constitutes only 1.3-3.2% of bladder cancer.…”

mentioning

confidence: 99%

“…Some studies report a 16-to 26-fold increased risk of cancer, 21,22 while other studies suggest that the risk is comparable to that of the general population. 23,24 Nevertheless, all groups convincingly show that squamous cell carcinoma of the bladder is overrepresented in this category of patients, comprising 19% 23 to 46.9% 21,22 of all bladder carcinomas; this is significantly higher than in the general population, where non-schistosomal squamous cell carcinoma constitutes only 1.3-3.2% of bladder cancer. 11 It is believed that a significant subset of squamous cell carcinoma arises in a background of squamous metaplasia that develops secondary to irritation related to long-term catheterization and recurrent urinary tract infections associated with neurogenic bladder.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Urothelial carcinoma with prominent squamous differentiation in the setting of neurogenic bladder: role of human papillomavirus infection

et al. 2012

View full text Add to dashboard Cite

Squamous cell carcinomas of the urinary bladder are rare in the Western world; the majority of cases are reported in countries endemic to Schistosoma parasitic infections. Unlike squamous tumors of the uterine cervix or oropharynx, the human papillomavirus (HPV) is not commonly associated with bladder squamous cell carcinomas. We report on two cases of HPV-positive urothelial carcinomas of the urinary bladder with extensive squamous differentiation showing the typical basaloid, poorly differentiated morphology of HPV-associated tumors. These occurred in patients with neurogenic bladders who had long-standing histories of selfcatheterization with tumors that tested positive for HPV by in situ hybridization. A retrospective review of our institutional database revealed four additional patients with bladder tumors showing squamous differentiation arising in the setting of neurogenic bladder. Review of these cases showed the more common welldifferentiated keratinizing appearance of squamous cell carcinomas of the bladder. These tumors showed only patchy positivity for p16 immunohistochemical stain (not the diffuse strong staining seen in HPV-positive tumors), and the one tested case was negative for HPV by in situ hybridization. HPV infection and neurogenic bladder have been independently associated with increased risk of developing carcinoma in the urinary bladder; however, this is the first report of squamous tumors arising in the setting of concurrent neurogenic bladder and HPV infection. The morphology of these tumors is similar to that of other high-risk HPV-associated squamous carcinomas with a basaloid, poorly differentiated appearance and little to no keratin formation. Modern Pathology (2012) 25, 1534-1542; doi:10.1038/modpathol.2012.112; published online 6 July 2012 Keywords: HPV; neurogenic bladder; squamous cell carcinoma; urothelial cancerThe human papillomavirus (HPV) has an important role as a human carcinogen, with an estimated 10% of cancers worldwide attributed to it. 1 HPV is a small circular double-stranded DNA virus with more than 100 different types described to date. 2 The potential of the virus to cause malignant or benign lesions dictates its classification into low-risk (6,11,40,42, and so on) or high-risk (16,18,31,33,45,51, and so on) types. The prototypical model for carcinogenesis is squamous cell carcinoma of the uterine cervix, in which nearly all such carcinomas are associated with HPV infection. 3,4 The oncogenic role of HPV is also well established for a subset of squamous cell carcinomas in the vulva, 5 penis, 6 anus, 7 and oropharynx. 8 The possible role of HPV infection in bladder tumors has not been completely elucidated as HPV detection rates vary widely from 0 to 100%, depending on the study. 9,10 An intriguing issue has been the possible association of the virus with bladder squamous cell carcinoma. The few published studies 11-14 on this relationship have shown a low frequency of HPV detection, implying that HPV is not likely to have a major role in the development of bladd...

show abstract

“…Obviously, in the case of SCI, it is not chemotherapy-induced but reduced mobility/ paralysis associated with a lack of metabolicallychallenging physical activity that causes secondarily the development of CVD. Moreover, chronic SCI has also been associated with greater incidence of some cancer (e.g., bladder, esophageal, liver and hematologic cancer) [10,11]. Physical activity has been shown to prevent and mitigate cardiotoxicity related to anthracycline therapy whereas a lack of physical activity due to paralysis after SCI increases the prevalence of chronic comorbid diseases including cancer [12,13].…”

Section: Editorialmentioning

confidence: 99%

Cardiovascular disease and cancer associated with neurological problems: Some hope for innovative combinatorial approaches

Pa¹

2017

Glob Drugs Therap

View full text Add to dashboard Cite

Bladder Cancer in Spinal Cord Injury Patients

Cited by 19 publications

References 0 publications

Quality of life and urological morbidity in tetraplegics with artificial ventilation managed with suprapubic or intermittent catheterisation

Quality of life and urological morbidity in tetraplegics with artificial ventilation managed with suprapubic or intermittent catheterisation

Urothelial carcinoma with prominent squamous differentiation in the setting of neurogenic bladder: role of human papillomavirus infection

Cardiovascular disease and cancer associated with neurological problems: Some hope for innovative combinatorial approaches

Contact Info

Product

Resources

About