Bladder cancer documentation of causes multilingual questionnaire bladder cancer doc

Golka, Klaus; Abreu‐Villaça, Yael; Attar, Rowshanak Anbari; Angeli-Greaves, Miriam; Aslam, Muhammad; Başaran, Nurşen; Belik, Rouslana; Butryee, Chaniphun; Dalpiaz, Orietta; Dzhusupov, Keneshbek; Ecke, Thorsten; Galambos, Henrieta; Gerilovica, Helena; Gerullis, Holger; Gonzalez, Patricia Casares; Goossens, Martine; Gorgishvili-Hermes, Lela; Heyns, Chris F.; Hodzic, Jasmin; Ikoma, Fumihiko; Jichlinski, Patrice; Kang, Boo Hyon; Kiesswetter, Ernst; Krishnamurthi, Kannan; Lehmann, Marie Louise; Martinova, Irina; Mittal, Rama Devi; Ravichandran, Beerappa; Romics, Imre; Roy, Bidyut; Rungkat-Zakaria, Fransiska; Rydzyński, K; Scutaru, Cristian; Shen, Jianhua; Soufi, Maria; Toguzbaeva, Karlygash; Duc, T. Vu; Widera, Agata; Wishahi, Mohamed; Hengstler, Jan G.

doi:10.2741/e585

Cited by 6 publications

(2 citation statements)

References 76 publications

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“…Certain authors have even established a guideline to assess occupational bladder cancer risk. For example, a German research group has provided a multilingual questionnaire on occupational and further bladder cancer risk factors [221]. This questionnaire asks for relevant medical information, for the occupational history since leaving school and for intensity and frequency of certain occupational and non-occupational risk factors.…”

Section: Resultsmentioning

confidence: 99%

Medical follow-up for workers exposed to bladder carcinogens: the French evidence-based and pragmatic statement

Clin

Pairon

2014

BMC Public Health

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BackgroundThe aim of this work was to establish recommendations for the medical follow-up of workers currently or previously exposed to carcinogenic substances for the bladder.MethodsA critical synthesis of the literature was conducted. Sectors of activity where workers are or were exposed to carcinogenic substances for the bladder were listed and classified according to the level of bladder cancer risk. Performances of techniques available for the targeted screening of bladder cancer were analysed, including a simulation of results among high-risk populations in France.ResultsThe risk level for the professional group and the latency period between the start of exposure and the natural history of the disease were selected to define a targeted screening protocol. The NMP22BC test, exclusive haematuria testing, and combinations of urine cytology with, respectively, the NMP22BC test and haematuria test, generated an extremely high proportion of false positive results.ConclusionUrine cytology is the test that offers the best specificity. Although poor for all bladder cancer stages and grades combined, its sensitivity is better for high grades, which require early diagnosis since late-stage cancers are of very poor prognosis. These results suggest that urine cytology is currently the only technique suitable for proposal within the context of a first line targeted screening strategy for occupational bladder cancer. An algorithm summarising the recommended medical follow-up for workers currently or previously exposed to carcinogenic substances for the bladder is proposed, based on the level of risk of bladder cancer.Electronic supplementary materialThe online version of this article (doi:10.1186/1471-2458-14-1155) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Medical follow-up for workers exposed to bladder carcinogens: the French evidence-based and pragmatic statement

Clin

Pairon

2014

BMC Public Health

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“…Information on profession obtained by questionnaire was available for the “East Germany” case-control series only (information on profession: 216 cases and 211 controls) [27], [28]. Detailed descriptions of these four case-control series can be found in [15].…”

Section: Methodsmentioning

confidence: 99%

Distinct SNP Combinations Confer Susceptibility to Urinary Bladder Cancer in Smokers and Non-Smokers

et al. 2012

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Recently, genome-wide association studies have identified and validated genetic variations associated with urinary bladder cancer (UBC). However, it is still unknown whether the high-risk alleles of several SNPs interact with one another, leading to an even higher disease risk. Additionally, there is no information available on how the UBC risk due to these SNPs compare to the risk of cigarette smoking and to occupational exposure to urinary bladder carcinogens, and whether the same or different SNP combinations are relevant in smokers and non-smokers. To address these questions, we analyzed the genotypes of six SNPs, previously found to be associated with UBC, together with the GSTM1 deletion, in 1,595 UBC cases and 1,760 controls, stratified for smoking habits. We identified the strongest interactions of different orders and tested the stability of their effect by bootstrapping. We found that different SNP combinations were relevant in smokers and non-smokers. In smokers, polymorphisms involved in detoxification of cigarette smoke carcinogens were most relevant (GSTM1, rs11892031), in contrast to those in non-smokers with MYC and APOBEC3A near polymorphisms (rs9642880, rs1014971) being the most influential. Stable combinations of up to three high-risk alleles resulted in higher odds ratios (OR) than the individual SNPs, although the interaction effect was less than additive. The highest stable combination effects resulted in an OR of about 2.0, which is still lower than the ORs of cigarette smoking (here, current smokers' OR: 3.28) and comparable to occupational carcinogen exposure risks which, depending on the workplace, show mostly ORs up to 2.0.

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Berufsbedingte Krebserkrankungen in der Urologie

Golka

Böthig

Jungmann

et al. 2021

Urologe

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Bladder cancer documentation of causes multilingual questionnaire bladder cancer doc

Cited by 6 publications

References 76 publications

Medical follow-up for workers exposed to bladder carcinogens: the French evidence-based and pragmatic statement

Medical follow-up for workers exposed to bladder carcinogens: the French evidence-based and pragmatic statement

Distinct SNP Combinations Confer Susceptibility to Urinary Bladder Cancer in Smokers and Non-Smokers

Berufsbedingte Krebserkrankungen in der Urologie

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