Bladder Cancer Associated with Hypercalcaemia

Eddeland, Allan; Hedelin, Hans

doi:10.3109/00365598009179563

Cited by 7 publications

(5 citation statements)

References 12 publications

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“…Hypercalcemia of malignancy is commonlyobserved in patients with breast cancer, lung cancer and renal cancer (3), and there have been somereports of cases of HHM associated with bladder carcinoma, including 1 1 patients with squamous cell carcinoma (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), 6 with transitional cell carcinoma (26, 28, 3 1-33), 2 with mixed transitional and squamous cell carcinoma (26), 1 with spindle and giant cell carcinoma (34), 2 with small cell carcinoma (35) and 4 with unspecified malignant tumors (36-38). However, those reports did not provide PTHrP measurementsor discuss its association with HHM.…”

Section: Discussionmentioning

confidence: 99%

Hypercalcemia Caused by PTH-rP Associated with Lung Metastasis from Urinary Bladder Carcinoma: An Autopsied Case.

et al. 1994

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Weanalyzed the parathyroid-related protein (PTH-rP) content in tissue specimens obtained from a 61-year-old manwith hypercalcemia associated with lung metastasis from urinary bladder carcinoma using radioimmunoassay and immunohistochemistry. Radioimmunoassayshowed that the PTH-rP content was higher in metastatic lung tumor tissue than in non-tumorous lung tissue. Immunohistochemicalanalysis revealed the presence of PTH-rPin tumor cells. Furthermore, proliferation of osteoclasts was found in bone marrowat autopsy. The results suggest that PTHrP induced humoral hypercalcemia of malignancy in a patient with urinary bladder cancer. (Internal Medicine 33: 673-676, 1994) Key words: humoral hypercalcemia of malignancy, metastatic tumor IntroductionThe hypercalcemia of malignancy maybe classified as either humoral hypercalcemia of malignancy (HHM)or local osteolytic hypercalcemia, depending on the etiology. Since Albright first proposed the clinical criteria for diagnosis of HHM(1), a number offactors that contribute to HHM, including parathyroidrelated protein (PTH-rP), transforming growth factors, prostaglandin E2, interleukin-1 , tumor necrosis factor (TNF)-a and TNF-B have been identified (2-6).PTH-rP contributes to the hypercalcemia found in patients with lung cancer (7), breast cancer, renal cancer (8), myeloma, and adult T-cell leukemia (9). The NH2-terminal regions of PTH-rP and parathyroid hormone are homologous (8, 10, 1 1). Both proteins, which have 34-amino acid NH2-terminals, have similar effects on renal and osteoblast cell membranes in vitro and on calcium and inorganic phosphate flux in vivo (12)(13)(14).Weperformed an autopsy in a patient who died of lung metastasis from urinary bladder carcinoma associated with hypercalcemia and investigated the presence of PTH-rP in cancer cells using radioimmunoassay (RIA) (15) and immunohistochemical studies. Case ReportA 61 -year-old Japanese man developed macrohematuria in March 1989. A cytoscopy revealed a tumor in the urinary bladder, which was hsitologically diagnosed as transitional cell carcinoma. In January 1990, he underwent total cystectomy. In October 1990, he complained of coughing and exertional dyspnea. A chest roentgenogram showed multiple tumors in the right lung field. Abronchofibroscopic examination showed that the bronchus of the right upper lobe was completely obstructed. A biopsy confirmed the presence of a pulmonary metastasis of transitional cell carcinoma of the urinary bladder. He underwent radiation therapy in November 1990. Radiation therapy (total 60 Gray) was administered to the right upper lung field. Radiation therapy improved atelectasis of the right upper lobe and eliminated the obstruction of the right upper bronchus. The patient was referred to our hospital on November7, 1992 for evaluation of dyspnea on exertion and fever. Onadmission, his temperature was 37.5°C, pulse rate 90/min, respiratory rate 1 8/ min, and blood pressure 122/60 mmHg.His performance status was grade 3. Physical examination revealed no masses in the head or ...

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Section: Discussionmentioning

confidence: 99%

Hypercalcemia Caused by PTH-rP Associated with Lung Metastasis from Urinary Bladder Carcinoma: An Autopsied Case.

et al. 1994

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“…The association of hypercalcemia and large tumors of the uroepithelium was previously described by Eddeland and Hedelin [5], We have been able to find 13 cases of hypercalcemia associated with uroepithelial tumors with documented histology in the literature. Of these tumors 4 were epidermoid carcinoma [5][6][7][8][9], 3 were squamous cell carcinoma [5,10,11], and 6 were transitional cell carci noma [12][13][14][15].…”

Section: Discussionmentioning

confidence: 51%

“…Of these tumors 4 were epidermoid carcinoma [5][6][7][8][9], 3 were squamous cell carcinoma [5,10,11], and 6 were transitional cell carci noma [12][13][14][15]. Squamous cell carcinoma accounts for about 15% of all bladder tumors with about 76% of tran sitional cell carcinoma [16], It is possible that squamous cell carcinomas are more commonly involved in releas ing hypercalcémie factor similar to the finding by Bender and Hansen [ 17] in bronchogenic carcinoma.…”

Section: Discussionmentioning

confidence: 90%

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Hypercalcemia Associated with Transitional Cell Carcinoma without Bone Metastases: Description of Two Cases

Har‐El¹,

Gafter²,

Zevin³

et al. 1985

Urol Int

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“…2 There are previous reports of humoral hypercalcemia and paraproteinemia associated with bladder cancers, but not simultaneously. [3][4][5][6][7] We report the first known case of squamous cell carcinoma of the bladder with paraproteinemia and symptomatic hypercalcemia. We also review the literature on humoral hypercalcemia.…”

Section: Introductionmentioning

confidence: 99%