Bladder Antibodies in Interstitial Cystitis

Silk, M.G.

doi:10.1016/s0022-5347(17)61948-7

Cited by 97 publications

(22 citation statements)

References 6 publications

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“…Local immunoglobulin deposition in the bladder wall is controversial (3,5,13,14). Bladder-specific antibodies have been demonstrated in the serum (3,14), although our group has not found them in our patients.…”

Section: Somes the Vesicles Were Not Uniform Enough Tomentioning

confidence: 51%

“…On the basis of this large mate rial and earlier negative findings we feel that local simple microbial infectious aetiology is ruled out in Discussion Interstitial cystitis is known to cause an increase in the circulating antinuclear antibodies (3,5,11). Local immunoglobulin deposition in the bladder wall is controversial (3,5,13,14). Bladder-specific antibodies have been demonstrated in the serum (3,14), although our group has not found them in our patients.…”

Section: Somes the Vesicles Were Not Uniform Enough Tomentioning

confidence: 56%

“…Two of these patients were later subjected to cystectomy and the The aetiology of interstitial cystitis (IC) has re mained a mystery. According to the latest investi gations (3,5,11,14) it is obvious that IC re sembles autoimmune diseases in that antitissue antibodies and other immune response abnormality can be found in these patients. Many hypotheses have been presented to explain the aetiology and also viral infection as a cause has been discussed.…”

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confidence: 99%

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Electron Microscopic and Histological Findings on Urinary Bladder Epithelium in Interstitial Cystitis

Collan¹,

Alfthan²,

Kivilaakso³

et al. 1976

Eur Urol

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Section: Somes the Vesicles Were Not Uniform Enough Tomentioning

confidence: 51%

Section: Somes the Vesicles Were Not Uniform Enough Tomentioning

confidence: 56%

mentioning

confidence: 99%

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Electron Microscopic and Histological Findings on Urinary Bladder Epithelium in Interstitial Cystitis

Collan¹,

Alfthan²,

Kivilaakso³

et al. 1976

Eur Urol

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“…Histologically, immune deposits of IgG, IgA, IgM or complement C1q are found in the mucosa and perivascular regions of urinary bladder specimens. The coexistence of antibladder antibodies was also proposed in patients with idiopathic interstitial cystitis, and autoimmune mechanisms are implicated as one cause of interstitial cystitis (4,(12)(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

Severe Interstitial Cystitis Associated with Sjoegren's Syndrome

et al. 2004

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A 53-year-old woman presented with oliguria, urinary frequency, abdominal pain and severe edema of the lower extremities. Her serum creatinine was 8.1 mg/dl. Computed tomographic and ultrasonographic studies showed a severely dilated urinary bladder, and bilateral hydroureteronephrosis. Examination of a urinary bladder biopsy specimen showed subepithelial edema and infiltration by lymphocytes and plasmacytes. However, the patient complainted of dry mouth and dry eyes. Ophthalmologically, the Schirmer test was positive. A biopsy of the minor salivary glands in the lip showed chronic sialoadenitis. A diagnosis of Sjögren's syndrome complicated by interstitial cystitis was made. Since she had been anuric, secondary to urinary obstruction, intermittent self-catheterization was started. Combination of corticosteroid and cyclosporin therapy was initiated. Spontaneous urination began, and gradually the patient's symptoms remitted. After 8 months of therapy, bladder capacity increased from 140 ml to 350 ml, and she voided approximately 1,200 ml by herself and 600 ml by catheterization daily. This case suggests that when severe interstitial cystitis is associated with Sjögren's syndrome, a therapeutic trial of corticosteroids and cyclosporin may be beneficial. (Internal Medicine 43: 248-252, 2004)

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“…It has been suggested thai interstitial cystitis might be an autoimmune disease [2] since circulating antibladder antibodies have been demonstrated in some ca,ses of inlerstitia! cystitis [4][5][6]. although others have failed to confirm these findings [7j,…”

Section: Introductionmentioning

confidence: 99%

Abnormal urothelial HLA-DR expression in interstitial cystitis

Christmas

Bottazzo

1992

Clinical and Experimental Immunology

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SUMMARY Interstitial cystitis is a chronic inflammatory disorder of the urinary bladder that predominantly afflicts middle‐age women. The end stage of the disease is ulceration of the urothelium, the so‐called Hunner's ulcer. The aetiology of interstitial cystitis remains obscure. We have studied bladder biopsies from 22 cases of interstitial cystitis and control groups consisting of six cases of bacterial cystitis and eight healthy women. Indirect immunofluorescence was performed on the biopsies using murine MoAbs to human HLA class I molecules, and class II molecules, HLA‐DP, HLA‐DQ and HLA‐DR. In interstitial cystitis, bacterial cystitis and normal controls most cells expressed HLA class I products. In six cases of interstitial cystitis and one case of bacterial cystitis there was evidence of HLA class I hyperexpression. In normal bladder and bacterial cystitis HLA class II expression was restricted to submucosal dendritic cells. Langerhans cells macrophages, vascular endothelial cells and activated lymphocytes. All but two cases of interstitial cystitis showed surface expression of HLA‐DR (but not HLA‐DP or DQ). In all cases of interstitial cystitis there was an increase in the numbers of macrophages, activated lymphocytes and vascular endothelial cells expressing HLA class II molecules within the submucosa. These findings provide further evidence fofthe importance of inappropriate HLA molecule expression in a disease suspected of having an autoimmune pathogenesis and where cellular autoimmune mechanisms play a decisive role in the destruction of the target cells ‐ the bladder urothelium.

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Bladder Antibodies in Interstitial Cystitis

Cited by 97 publications

References 6 publications

Electron Microscopic and Histological Findings on Urinary Bladder Epithelium in Interstitial Cystitis

Electron Microscopic and Histological Findings on Urinary Bladder Epithelium in Interstitial Cystitis

Severe Interstitial Cystitis Associated with Sjoegren's Syndrome

Abnormal urothelial HLA-DR expression in interstitial cystitis

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