Blad-containing oligomer: a novel fungicide used in crop protection as an alternative treatment for tinea pedis and tinea versicolor

Carreira, Alexandra; Pereira, Iliana; Ferreira, João Boavida; Filipe, Paulo; Ferreira, Ricardo B.; Monteiro, Sara

doi:10.1099/jmm.0.000675

Cited by 9 publications

(5 citation statements)

References 52 publications

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“…A small number of publications report activity in vitro of other agents against Malassezia spp. These include plant‐derived substances such as Blad‐containing oligomer (an antifungal agent approved for agricultural use); beta‐thujaplicin, a honey‐based gel, kanuka and manuka and other plant‐derived essential oils; agents primarily used in the topical treatment of human dandruff or seborrhoeic dermatitis (selenium sulphide, zinc pyrithione, ciclopiroxolamine, rilopirox) and povidone–iodine . The calcineurin inhibitors (tacrolimus and pimecrolimus) have activity in vitro against human‐associated Malassezia yeasts .…”

Section: Antifungal Susceptibility Testing and Resistancementioning

confidence: 99%

Biology, diagnosis and treatment ofMalasseziadermatitis in dogs and cats Clinical Consensus Guidelines of the World Association for Veterinary Dermatology

Bond

Morris

Guillot

et al. 2020

Veterinary Dermatology

118

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Background -The genus Malassezia is comprised of a group of lipophilic yeasts that have evolved as skin commensals and opportunistic cutaneous pathogens of a variety of mammals and birds.Objectives -The objective of this document is to provide the veterinary community and other interested parties with current information on the ecology, pathophysiology, diagnosis, treatment and prevention of skin diseases associated with Malassezia yeasts in dogs and cats.Methods and material -The authors served as a Guideline Panel (GP) and reviewed the literature available prior to October 2018. The GP prepared a detailed literature review and made recommendations on selected topics. The World Association of Veterinary Dermatology (WAVD) Clinical Consensus Guideline committee provided guidance and oversight for this process. The document was presented at two international meetings of veterinary dermatology societies and one international mycology workshop; it was made available for comment on the WAVD website for a period of six months. Comments were shared with the GP electronically and responses incorporated into the final document.Conclusions and clinical importance -There has been a remarkable expansion of knowledge on Malassezia yeasts and their role in animal disease, particularly since the early 1990's. Malassezia dermatitis in dogs and cats has evolved from a disease of obscurity and controversy on its existence, to now being a routine diagnosis in general veterinary practice. Clinical signs are well recognised and diagnostic approaches are well developed. A range of topical and systemic therapies is known to be effective, especially when predisposing factors are identified and corrected.

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Section: Antifungal Susceptibility Testing and Resistancementioning

confidence: 99%

Biology, diagnosis and treatment ofMalasseziadermatitis in dogs and cats Clinical Consensus Guidelines of the World Association for Veterinary Dermatology

Bond

Morris

Guillot

et al. 2020

Veterinary Dermatology

118

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“…Several advantages for human health are attributed to chickpea proteins and lupin proteins: the lupin lectin γ-conglutin, a globulin composed of 42 kDa subunits, showed beneficial properties through its reducing effect in glycemia being suitable for diabetics ( 14 , 51 ); the deflamin protein found in legume seeds, namely lupin and chickpea, has been shown to be anti-inflammatory in in vitro models with various colon cancer cell lines as well as in vivo models of acute and chronic disease, presenting inhibitory bioactivity against MMP-9 ( 24 , 27 ). Also, the seed reserve protein β-conglutin from Lupinus albus exerted action on glycemic modulation and reduced the circulating cholesterol ( 15 ), and a natural 210 kDa glyco-oligomer fungicide, termed Blad-containing oligomer present in Lupinus albus , showed potent antifungal activity against both human and phytopathogenic fungi ( 52 ).…”

Section: Discussionmentioning

confidence: 99%

New Alternatives to Milk From Pulses: Chickpea and Lupin Beverages With Improved Digestibility and Potential Bioactivities for Human Health

et al. 2022

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There is a strong demand for plant-based milk substitutes, often low in protein content (<1.5% w/v). Protein-rich pulse seeds and the right processing technologies make it possible to make relevant choices. The major objective of this study was to assess the impact of processing on the nutritional characteristics of beverages with a high impact on health, in particular on digestibility and specific bioactivities. The results suggest that pulse beverages are as high in protein content (3.24% w/v for chickpea and 4.05% w/v for lupin) as cow’s milk. The anti-nutrient level characteristics of pulses have been considerably reduced by strategic processing. However, when present in small quantities, some of these anti-nutritional factors may have health benefits. Controlling processing conditions play a crucial role in this fine balance as a tool to take advantage of their health benefits. There is evidence of protein hydrolysis by in vitro digestion and limited bioaccessibility of minerals. In addition to being highly digestible, lupin and chickpea beverages have anti-inflammatory and anti-carcinogenic potential evaluated through the inhibition of metalloproteinase MMP-9.

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“…Oral medication is effective for all types of Tinea pedis. There are four classes of systemic and topical antifungal medications used for treating fungal infections and therefore Tinea pedis 56,57 . These are; the polyenes antibiotics, the azole derivatives, the allylamines/thiocarbamates, and the fluoropyrimidines 56,58 .…”

Section: Treatment Optionsmentioning

confidence: 99%

Dermatophytic Diseases: A Review of Tinea Pedis

Jg¹,

Ra³

et al. 2021

Preprint

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Background Skin diseases, particularly Tinea pedis are very rare in Ghana leading to low investment in dermatological services in the country and the African continent. Globally, Tinea pedis affects about 15% of the global population. Importantly, it is a major public health problem and socioeconomic issue. Currently, the most recommended treatment for Tinea pedis infection are polyenes, azoles, allylamines, and fluorocytosines. Although these drugs are effective, they do have adverse side effects and are limited in the clinical settings in developing countries especially Ghana. Method: Research papers were collected from Pubmed, Google scholar, chemical abstracts, and journal websites, reporting both in vitro and in vivo information on Tinea pedis. General information on Tinea pedis, the methods of infection, transfer, treatment options, and resistance were obtained after screening the articles. Many agents are involved in cases of Tinea pedis but are predominantly caused by Trichophyton rubrum which feeds on the keratinous layer of the topmost skin of the foot causing skin discoloration, itching, and maceration. The disease is influenced by individual lifestyle, environmental conditions, and individual factors such as age, sex, and host immunity and is prevented by the maintenance of good personal hygiene.Tinea pedis like other tinea infections are treated with both topical and systemic agents. The classes of medications used in the treatment of Tinea pedis are polyenes, azoles, allylamines, and fluorocytosines. Tinea pedis antifungal resistance development could be partly associated with incomplete medication and misuse of antifungal medications. Additionally, patients with serious underlying health conditions such as compromised immune systems like HIV/AIDS, diabetes, radiotherapy for cancer, and transplantation could complicate resistance. Conclusion: Although, fungal diseases do not cause epidemics the increasing rate of fungal infections and therefore Tinea pedis has to be checked and prevented. High budgets are made in the development of medications which mostly lose their effectiveness over time due to resistance development. Good personal hygiene is very effective but the available medications must be used appropriately for effective treatment and resistance avoidance. Infection prevention and control, tracking and data sharing, good and easily accessible antifungals, vaccines, and maintenance of personal and environmental hygiene are the topmost preventive measures against resistance development.

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Blad-containing oligomer: a novel fungicide used in crop protection as an alternative treatment for tinea pedis and tinea versicolor

Abstract: These data place BCO as a promising drug for the treatment of Malassezia-associated skin diseases. Further in vivo studies are now required to ascertain its applicability in the clinical setting.

Cited by 9 publications

References 52 publications

Biology, diagnosis and treatment ofMalasseziadermatitis in dogs and cats Clinical Consensus Guidelines of the World Association for Veterinary Dermatology

Biology, diagnosis and treatment ofMalasseziadermatitis in dogs and cats Clinical Consensus Guidelines of the World Association for Veterinary Dermatology

New Alternatives to Milk From Pulses: Chickpea and Lupin Beverages With Improved Digestibility and Potential Bioactivities for Human Health

Dermatophytic Diseases: A Review of Tinea Pedis

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